Comparison of retinal nerve fiber layer thickness, macula thickness and optic nerve head parameters in opioid dependent and normal adult

Introduction Drug abuse is a socioeconomic problem that affects the public of the country. Heroin and morphine, which falls under the opioid group continues to be the commonest drug of abuse in Malaysia. Opioid usage is associated with addiction and dependence, and reported ocular side effects a...

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Main Author:	Kuen, Wong Chee
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RE Ophthalmology
Online Access:	http://eprints.usm.my/42948/1/Dr._Wong_Chee_Kuen-24_pages.pdf
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id	my-usm-ep.42948
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spelling	my-usm-ep.429482019-04-12T05:25:31Z Comparison of retinal nerve fiber layer thickness, macula thickness and optic nerve head parameters in opioid dependent and normal adult 2016 Kuen, Wong Chee RE Ophthalmology Introduction Drug abuse is a socioeconomic problem that affects the public of the country. Heroin and morphine, which falls under the opioid group continues to be the commonest drug of abuse in Malaysia. Opioid usage is associated with addiction and dependence, and reported ocular side effects are pupillary miosis, conjunctiva hyperemia, ocular motility disorder and risk of complication such as endophtalmitis. It was also reported that chronic opioid usage leads to neurological degeneration. Objective To compare the retinal nerve fiber layer thickness, macula thickness and optic nerve head parameters in opioid dependent and normal adult. Method The study design was a case control with opioid dependent individuals and healthy individuals recruited from the Methadone Clinic, Department of Psychiatry and Ophthalmology Clinic, Department of Ophthalmology, Hospital Universiti Sains Malaysia. Thirty five opioid dependent subjects and thirty five healthy subjects with no history of opioid use were recruited. Ophthalmological examination and optical coherence tomography (Heidelberg Spectralis ® OCT) were performed. Results Compared to normal healthy subjects, opioid dependent group has thinner average retinal nerve fiber layer in the right eye (p<0.05) and in both superior quadrant of the optic nerve (p<0.05). Analysis of other segments did not show any statistical significance Conclusion Early thinning of the retinal nerve fiber layer could be one of the early signs of complication from long term opioid usage. Further studies may be needed to determine if further thinning occurs with time and the implication to the patients’ vision. 2016 Thesis http://eprints.usm.my/42948/ http://eprints.usm.my/42948/1/Dr._Wong_Chee_Kuen-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RE Ophthalmology
spellingShingle	RE Ophthalmology Kuen, Wong Chee Comparison of retinal nerve fiber layer thickness, macula thickness and optic nerve head parameters in opioid dependent and normal adult
description	Introduction Drug abuse is a socioeconomic problem that affects the public of the country. Heroin and morphine, which falls under the opioid group continues to be the commonest drug of abuse in Malaysia. Opioid usage is associated with addiction and dependence, and reported ocular side effects are pupillary miosis, conjunctiva hyperemia, ocular motility disorder and risk of complication such as endophtalmitis. It was also reported that chronic opioid usage leads to neurological degeneration. Objective To compare the retinal nerve fiber layer thickness, macula thickness and optic nerve head parameters in opioid dependent and normal adult. Method The study design was a case control with opioid dependent individuals and healthy individuals recruited from the Methadone Clinic, Department of Psychiatry and Ophthalmology Clinic, Department of Ophthalmology, Hospital Universiti Sains Malaysia. Thirty five opioid dependent subjects and thirty five healthy subjects with no history of opioid use were recruited. Ophthalmological examination and optical coherence tomography (Heidelberg Spectralis ® OCT) were performed. Results Compared to normal healthy subjects, opioid dependent group has thinner average retinal nerve fiber layer in the right eye (p<0.05) and in both superior quadrant of the optic nerve (p<0.05). Analysis of other segments did not show any statistical significance Conclusion Early thinning of the retinal nerve fiber layer could be one of the early signs of complication from long term opioid usage. Further studies may be needed to determine if further thinning occurs with time and the implication to the patients’ vision.
format	Thesis
qualification_level	Master's degree
author	Kuen, Wong Chee
author_facet	Kuen, Wong Chee
author_sort	Kuen, Wong Chee
title	Comparison of retinal nerve fiber layer thickness, macula thickness and optic nerve head parameters in opioid dependent and normal adult
title_short	Comparison of retinal nerve fiber layer thickness, macula thickness and optic nerve head parameters in opioid dependent and normal adult
title_full	Comparison of retinal nerve fiber layer thickness, macula thickness and optic nerve head parameters in opioid dependent and normal adult
title_fullStr	Comparison of retinal nerve fiber layer thickness, macula thickness and optic nerve head parameters in opioid dependent and normal adult
title_full_unstemmed	Comparison of retinal nerve fiber layer thickness, macula thickness and optic nerve head parameters in opioid dependent and normal adult
title_sort	comparison of retinal nerve fiber layer thickness, macula thickness and optic nerve head parameters in opioid dependent and normal adult
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2016
url	http://eprints.usm.my/42948/1/Dr._Wong_Chee_Kuen-24_pages.pdf
_version_	1747821133761085440

Comparison of retinal nerve fiber layer thickness, macula thickness and optic nerve head parameters in opioid dependent and normal adult

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