The effect of modified alternate day calorie restriction (MACR) on non-alcoholic fatty liver disease (NAFLD)

Background: Non-alcoholic fatty liver diseases are an important cause of morbidity and mortality due to adverse cardiovascular outcomes and also liver-related complications. Currently, there is no approved therapy for non-alcoholic fatty liver diseases; weight reduction is typically recommended. Mo...

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Main Author:	Johari, Muhammad Izzad
Format:	Thesis
Language:	English
Published:	2017
Subjects:	RC799-869 Diseases of the digestive system Gastroenterology
Online Access:	http://eprints.usm.my/43125/1/Dr._Muhammad_Izzad-24_pages.pdf
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spelling	my-usm-ep.431252019-04-12T05:25:06Z The effect of modified alternate day calorie restriction (MACR) on non-alcoholic fatty liver disease (NAFLD) 2017 Johari, Muhammad Izzad RC799-869 Diseases of the digestive system. Gastroenterology Background: Non-alcoholic fatty liver diseases are an important cause of morbidity and mortality due to adverse cardiovascular outcomes and also liver-related complications. Currently, there is no approved therapy for non-alcoholic fatty liver diseases; weight reduction is typically recommended. Modified alternate day calorie restriction is more feasible to the patient compared to daily calorie restriction; however, no trials have been done in non-alcoholic fatty liver diseases patients focusing on changes in liver fibrosis and steatosis. Objectives: The aim of this study is to evaluate the effect of modified alternate day calorie restriction on the changes in liver steatosis and fibrosis, anthropometry as well as biochemical parameters in non-alcoholic fatty liver diseases patients after 8 weeks of modified alternate day calorie restriction.Methods: We performed a prospective study involving adult gastroenterology patients with non-alcoholic fatty liver disease from August 2015 to July 2016 in Hospital Universiti Sains Malaysia. Results: A total of 105 patients were screened, 41 consented but 11 withdrew and 30 participants (mean age 43.9 years, BMI 31.5kg/m2, males 70%, diabetes 53%) completed the study. With 8 week MACR, significant reductions were observed of grading of liver steatosis (40% reduction in those with moderate steatosis, P=0.001), SWE (mean difference 0.9, P=0.001), BMI (mean difference 0.6 kg/m2, P=0.003), glucose (median difference 0.3 mmol/L, P=0.01), ALT (median difference 20.5 U/L, P=0.001) and AST (median difference 9 U/L, P=0.002) Conclusion: In summary, the results indicate that modified alternate day calorie restriction appear to be an effective diet strategy to help reducing the risk of progression for non-alcoholic fatty liver diseases especially in patients with moderate steatosis and mild fibrosis. 2017 Thesis http://eprints.usm.my/43125/ http://eprints.usm.my/43125/1/Dr._Muhammad_Izzad-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC799-869 Diseases of the digestive system Gastroenterology
spellingShingle	RC799-869 Diseases of the digestive system Gastroenterology Johari, Muhammad Izzad The effect of modified alternate day calorie restriction (MACR) on non-alcoholic fatty liver disease (NAFLD)
description	Background: Non-alcoholic fatty liver diseases are an important cause of morbidity and mortality due to adverse cardiovascular outcomes and also liver-related complications. Currently, there is no approved therapy for non-alcoholic fatty liver diseases; weight reduction is typically recommended. Modified alternate day calorie restriction is more feasible to the patient compared to daily calorie restriction; however, no trials have been done in non-alcoholic fatty liver diseases patients focusing on changes in liver fibrosis and steatosis. Objectives: The aim of this study is to evaluate the effect of modified alternate day calorie restriction on the changes in liver steatosis and fibrosis, anthropometry as well as biochemical parameters in non-alcoholic fatty liver diseases patients after 8 weeks of modified alternate day calorie restriction.Methods: We performed a prospective study involving adult gastroenterology patients with non-alcoholic fatty liver disease from August 2015 to July 2016 in Hospital Universiti Sains Malaysia. Results: A total of 105 patients were screened, 41 consented but 11 withdrew and 30 participants (mean age 43.9 years, BMI 31.5kg/m2, males 70%, diabetes 53%) completed the study. With 8 week MACR, significant reductions were observed of grading of liver steatosis (40% reduction in those with moderate steatosis, P=0.001), SWE (mean difference 0.9, P=0.001), BMI (mean difference 0.6 kg/m2, P=0.003), glucose (median difference 0.3 mmol/L, P=0.01), ALT (median difference 20.5 U/L, P=0.001) and AST (median difference 9 U/L, P=0.002) Conclusion: In summary, the results indicate that modified alternate day calorie restriction appear to be an effective diet strategy to help reducing the risk of progression for non-alcoholic fatty liver diseases especially in patients with moderate steatosis and mild fibrosis.
format	Thesis
qualification_level	Master's degree
author	Johari, Muhammad Izzad
author_facet	Johari, Muhammad Izzad
author_sort	Johari, Muhammad Izzad
title	The effect of modified alternate day calorie restriction (MACR) on non-alcoholic fatty liver disease (NAFLD)
title_short	The effect of modified alternate day calorie restriction (MACR) on non-alcoholic fatty liver disease (NAFLD)
title_full	The effect of modified alternate day calorie restriction (MACR) on non-alcoholic fatty liver disease (NAFLD)
title_fullStr	The effect of modified alternate day calorie restriction (MACR) on non-alcoholic fatty liver disease (NAFLD)
title_full_unstemmed	The effect of modified alternate day calorie restriction (MACR) on non-alcoholic fatty liver disease (NAFLD)
title_sort	effect of modified alternate day calorie restriction (macr) on non-alcoholic fatty liver disease (nafld)
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2017
url	http://eprints.usm.my/43125/1/Dr._Muhammad_Izzad-24_pages.pdf
_version_	1747821169433640960

The effect of modified alternate day calorie restriction (MACR) on non-alcoholic fatty liver disease (NAFLD)

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