Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy.

Hiperhomosisteinemia terjadi disebabkan oleh penurunan aras kofaktor-kofaktor (vitamin B12, B6 dan folat) dan / atau akibat kekurangan keberkesanan enzim methylene tetrahydrofolate reductase (MTHFR). Keadaan ini telah dikaitkan dengan risiko kejadian ‘atherosclerosis’ yang merupakan salah satu facto...

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Main Author:	Al Jabr, Mohamed Talal Abd Alfattah
Format:	Thesis
Language:	English
Published:	2011
Subjects:	R5-920 Medicine (General)
Online Access:	http://eprints.usm.my/43139/1/Pages_from_RBC_PARAMETERS.pdf
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id	my-usm-ep.43139
record_format	uketd_dc
spelling	my-usm-ep.431392018-12-13T06:15:57Z Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy. 2011 Al Jabr, Mohamed Talal Abd Alfattah R5-920 Medicine (General) Hiperhomosisteinemia terjadi disebabkan oleh penurunan aras kofaktor-kofaktor (vitamin B12, B6 dan folat) dan / atau akibat kekurangan keberkesanan enzim methylene tetrahydrofolate reductase (MTHFR). Keadaan ini telah dikaitkan dengan risiko kejadian ‘atherosclerosis’ yang merupakan salah satu factor penyumbang kepada penyakit jantung koronari di kalangan wanita menopaus. Adalah tidak di ketahui samada perubahan pada parameter-parameter sel darah merah boleh terjadi tanpa melibatkan ketidak normalan pada aras vitamin B12 dan folat di kalangan wanita menopaus yang berkaitan dengan kehadiran hiperhomosisteinemia. Hyperhomocysteinemia occurs as a result of decreased levels of cofactors (vitamin B6, vitamin B12 and folate) and/or reduced efficiency of Methylenetetrahydrofolate reductase (MTHFR) enzyme. Hyperhomocysteinemia is an independent risk factor for atherosclerosis and may be one of the factors predisposing for coronary heart disease (CHD) in postmenopausal women. It is not well known whether changes in red blood cells parameters can occur independently of B12 and folate abnormalities in postmenopausal women in association with hyperhomocysteinemia. 2011 Thesis http://eprints.usm.my/43139/ http://eprints.usm.my/43139/1/Pages_from_RBC_PARAMETERS.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R5-920 Medicine (General)
spellingShingle	R5-920 Medicine (General) Al Jabr, Mohamed Talal Abd Alfattah Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy.
description	Hiperhomosisteinemia terjadi disebabkan oleh penurunan aras kofaktor-kofaktor (vitamin B12, B6 dan folat) dan / atau akibat kekurangan keberkesanan enzim methylene tetrahydrofolate reductase (MTHFR). Keadaan ini telah dikaitkan dengan risiko kejadian ‘atherosclerosis’ yang merupakan salah satu factor penyumbang kepada penyakit jantung koronari di kalangan wanita menopaus. Adalah tidak di ketahui samada perubahan pada parameter-parameter sel darah merah boleh terjadi tanpa melibatkan ketidak normalan pada aras vitamin B12 dan folat di kalangan wanita menopaus yang berkaitan dengan kehadiran hiperhomosisteinemia. Hyperhomocysteinemia occurs as a result of decreased levels of cofactors (vitamin B6, vitamin B12 and folate) and/or reduced efficiency of Methylenetetrahydrofolate reductase (MTHFR) enzyme. Hyperhomocysteinemia is an independent risk factor for atherosclerosis and may be one of the factors predisposing for coronary heart disease (CHD) in postmenopausal women. It is not well known whether changes in red blood cells parameters can occur independently of B12 and folate abnormalities in postmenopausal women in association with hyperhomocysteinemia.
format	Thesis
qualification_level	Master's degree
author	Al Jabr, Mohamed Talal Abd Alfattah
author_facet	Al Jabr, Mohamed Talal Abd Alfattah
author_sort	Al Jabr, Mohamed Talal Abd Alfattah
title	Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy.
title_short	Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy.
title_full	Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy.
title_fullStr	Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy.
title_full_unstemmed	Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy.
title_sort	rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal malay women and their relation to hormone replacement therapy.
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2011
url	http://eprints.usm.my/43139/1/Pages_from_RBC_PARAMETERS.pdf
_version_	1747821172869824512

Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy.

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