A prospective double-blinded randomized controlled trial of the efficacy of haruan (channa striatus) spray on clean wounds

Background Channa striatus (Haruan), a fresh water fish indigenous to many tropical countries have long been regarded as valuable food fish in the Far East. Several studies showed, the Haruan did contain all the essential amino acids and fatty acids uniquely capable of accelerating the wound hea...

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主要作者:	Lah, Nik Amin Sahid Nik
格式:	Thesis
語言:	English
出版:	2017
主題:	RD Surgery
在線閱讀:	http://eprints.usm.my/43153/1/Dr._Nik_Amin_Sahid_Nik_Lah-24_pages.pdf
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id	my-usm-ep.43153
record_format	uketd_dc
spelling	my-usm-ep.431532019-04-12T05:25:07Z A prospective double-blinded randomized controlled trial of the efficacy of haruan (channa striatus) spray on clean wounds 2017 Lah, Nik Amin Sahid Nik RD Surgery Background Channa striatus (Haruan), a fresh water fish indigenous to many tropical countries have long been regarded as valuable food fish in the Far East. Several studies showed, the Haruan did contain all the essential amino acids and fatty acids uniquely capable of accelerating the wound healing and it has anti-nociceptive effect. However so far no human study been done to assess the effectiveness of Channa striatus in wound healing. A prospective randomize controlled trial has been conducted on the effect of Channa striatus Spray versus placebo on clean wound to assess its pain control effect and cosmetic outcome. Methodology Hundred and two patients (102) underwent clean elective surgery; post-operatively they are randomized into two group. One group received Channa striatus Extract spray (n=51) another group receive placebo (n=51) on daily basis for 2 week. Then they were follow up on 2nd, 4th and 6th week to assess the pain control effect based on Visual Analog Pain Score (VAPS) and cosmetic outcome based on Visual Analogue Cosmetic Scale (VACS), Wound Evaluation Scale(WES) and Vancouver Scar Scale (VSS). Result The patient treated with Channa striatus spray displayed a better outcome in term of pain control compared to placebo. During analysis using repeated measure ANOVA, there was significant difference of patient’s pain score based on VAPS between Channa striatus spray and placebo (F-stat(df) = 4.80 (2), p-value = 0.010). In term of cosmetic outcome it showed a consistent significant better result in haruan spray group for all the 3 scoring system which is VACS, (F-stat(df) = 2.68 (2) , p-value <0.001), WES (F-stat(df) = 3.09 (2), p-value = 0.048). and VSS , F-stat(df) = 1.72 (2) , p-value = 0.011). Conclusion Our study suggest that application of Haruan Extract spray on clean wound has shown a significant better pain score result and cosmetic outcome on week 2, week 4 and week 6 comparatively with placebo 2017 Thesis http://eprints.usm.my/43153/ http://eprints.usm.my/43153/1/Dr._Nik_Amin_Sahid_Nik_Lah-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RD Surgery
spellingShingle	RD Surgery Lah, Nik Amin Sahid Nik A prospective double-blinded randomized controlled trial of the efficacy of haruan (channa striatus) spray on clean wounds
description	Background Channa striatus (Haruan), a fresh water fish indigenous to many tropical countries have long been regarded as valuable food fish in the Far East. Several studies showed, the Haruan did contain all the essential amino acids and fatty acids uniquely capable of accelerating the wound healing and it has anti-nociceptive effect. However so far no human study been done to assess the effectiveness of Channa striatus in wound healing. A prospective randomize controlled trial has been conducted on the effect of Channa striatus Spray versus placebo on clean wound to assess its pain control effect and cosmetic outcome. Methodology Hundred and two patients (102) underwent clean elective surgery; post-operatively they are randomized into two group. One group received Channa striatus Extract spray (n=51) another group receive placebo (n=51) on daily basis for 2 week. Then they were follow up on 2nd, 4th and 6th week to assess the pain control effect based on Visual Analog Pain Score (VAPS) and cosmetic outcome based on Visual Analogue Cosmetic Scale (VACS), Wound Evaluation Scale(WES) and Vancouver Scar Scale (VSS). Result The patient treated with Channa striatus spray displayed a better outcome in term of pain control compared to placebo. During analysis using repeated measure ANOVA, there was significant difference of patient’s pain score based on VAPS between Channa striatus spray and placebo (F-stat(df) = 4.80 (2), p-value = 0.010). In term of cosmetic outcome it showed a consistent significant better result in haruan spray group for all the 3 scoring system which is VACS, (F-stat(df) = 2.68 (2) , p-value <0.001), WES (F-stat(df) = 3.09 (2), p-value = 0.048). and VSS , F-stat(df) = 1.72 (2) , p-value = 0.011). Conclusion Our study suggest that application of Haruan Extract spray on clean wound has shown a significant better pain score result and cosmetic outcome on week 2, week 4 and week 6 comparatively with placebo
format	Thesis
qualification_level	Master's degree
author	Lah, Nik Amin Sahid Nik
author_facet	Lah, Nik Amin Sahid Nik
author_sort	Lah, Nik Amin Sahid Nik
title	A prospective double-blinded randomized controlled trial of the efficacy of haruan (channa striatus) spray on clean wounds
title_short	A prospective double-blinded randomized controlled trial of the efficacy of haruan (channa striatus) spray on clean wounds
title_full	A prospective double-blinded randomized controlled trial of the efficacy of haruan (channa striatus) spray on clean wounds
title_fullStr	A prospective double-blinded randomized controlled trial of the efficacy of haruan (channa striatus) spray on clean wounds
title_full_unstemmed	A prospective double-blinded randomized controlled trial of the efficacy of haruan (channa striatus) spray on clean wounds
title_sort	prospective double-blinded randomized controlled trial of the efficacy of haruan (channa striatus) spray on clean wounds
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2017
url	http://eprints.usm.my/43153/1/Dr._Nik_Amin_Sahid_Nik_Lah-24_pages.pdf
_version_	1747821173852340224

A prospective double-blinded randomized controlled trial of the efficacy of haruan (channa striatus) spray on clean wounds

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