Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma

This study aims to investigate the anti-angiogenic and anti-colon cancer activity of the extracts and isolates of Syzygium campanulatum and Garcinia mangostana. And to prepare G. mangostana toluene extract in nanoparticles and α-mangostin in solid dispersions in order to improve their aqueous solub...

Full description

Saved in:

Bibliographic Details
Main Author:	Aisha, Abdalrahim F. A.
Format:	Thesis
Language:	English
Published:	2011
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/43187/1/ABDALRAHIM%20F.%20A.%20AISHA.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.43187
record_format	uketd_dc
spelling	my-usm-ep.431872019-04-12T05:26:26Z Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma 2011-12 Aisha, Abdalrahim F. A. RS1-441 Pharmacy and materia medica This study aims to investigate the anti-angiogenic and anti-colon cancer activity of the extracts and isolates of Syzygium campanulatum and Garcinia mangostana. And to prepare G. mangostana toluene extract in nanoparticles and α-mangostin in solid dispersions in order to improve their aqueous solubility. Phytochemical analysis of S. campanulatum extracts reveals relatively high concentration of betulinic acid (BA) and polyphenols. BA fraction from S. campanulatum showed potent cytotoxicity on colon cancer cells by inducting the mitochondrial pathway of apoptosis. Extracts also showed potent inhibition of angiogenesis in several in vitro and in vivo models, by inhibiting the expression of vascular endothelial growth factor and inhibiting migration of human endothelial cells. The methanolic extract also inhibits tumor growth in xenograft tumor model with inhibition of intratumor blood vessels. 2011-12 Thesis http://eprints.usm.my/43187/ http://eprints.usm.my/43187/1/ABDALRAHIM%20F.%20A.%20AISHA.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Aisha, Abdalrahim F. A. Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma
description	This study aims to investigate the anti-angiogenic and anti-colon cancer activity of the extracts and isolates of Syzygium campanulatum and Garcinia mangostana. And to prepare G. mangostana toluene extract in nanoparticles and α-mangostin in solid dispersions in order to improve their aqueous solubility. Phytochemical analysis of S. campanulatum extracts reveals relatively high concentration of betulinic acid (BA) and polyphenols. BA fraction from S. campanulatum showed potent cytotoxicity on colon cancer cells by inducting the mitochondrial pathway of apoptosis. Extracts also showed potent inhibition of angiogenesis in several in vitro and in vivo models, by inhibiting the expression of vascular endothelial growth factor and inhibiting migration of human endothelial cells. The methanolic extract also inhibits tumor growth in xenograft tumor model with inhibition of intratumor blood vessels.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Aisha, Abdalrahim F. A.
author_facet	Aisha, Abdalrahim F. A.
author_sort	Aisha, Abdalrahim F. A.
title	Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma
title_short	Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma
title_full	Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma
title_fullStr	Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma
title_full_unstemmed	Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma
title_sort	anti-cancer studies of garcinia mangostana l. and syzygium campanulatum korth towards colorectal carcinoma
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2011
url	http://eprints.usm.my/43187/1/ABDALRAHIM%20F.%20A.%20AISHA.pdf
_version_	1747821176814567424

Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma

Similar Items