Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma

This study aims to investigate the anti-angiogenic and anti-colon cancer activity of the extracts and isolates of Syzygium campanulatum and Garcinia mangostana. And to prepare G. mangostana toluene extract in nanoparticles and α-mangostin in solid dispersions in order to improve their aqueous solub...

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Main Author: Aisha, Abdalrahim F. A.
Format: Thesis
Language:English
Published: 2011
Subjects:
Online Access:http://eprints.usm.my/43187/1/ABDALRAHIM%20F.%20A.%20AISHA.pdf
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spelling my-usm-ep.431872019-04-12T05:26:26Z Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma 2011-12 Aisha, Abdalrahim F. A. RS1-441 Pharmacy and materia medica This study aims to investigate the anti-angiogenic and anti-colon cancer activity of the extracts and isolates of Syzygium campanulatum and Garcinia mangostana. And to prepare G. mangostana toluene extract in nanoparticles and α-mangostin in solid dispersions in order to improve their aqueous solubility. Phytochemical analysis of S. campanulatum extracts reveals relatively high concentration of betulinic acid (BA) and polyphenols. BA fraction from S. campanulatum showed potent cytotoxicity on colon cancer cells by inducting the mitochondrial pathway of apoptosis. Extracts also showed potent inhibition of angiogenesis in several in vitro and in vivo models, by inhibiting the expression of vascular endothelial growth factor and inhibiting migration of human endothelial cells. The methanolic extract also inhibits tumor growth in xenograft tumor model with inhibition of intratumor blood vessels. 2011-12 Thesis http://eprints.usm.my/43187/ http://eprints.usm.my/43187/1/ABDALRAHIM%20F.%20A.%20AISHA.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Aisha, Abdalrahim F. A.
Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma
description This study aims to investigate the anti-angiogenic and anti-colon cancer activity of the extracts and isolates of Syzygium campanulatum and Garcinia mangostana. And to prepare G. mangostana toluene extract in nanoparticles and α-mangostin in solid dispersions in order to improve their aqueous solubility. Phytochemical analysis of S. campanulatum extracts reveals relatively high concentration of betulinic acid (BA) and polyphenols. BA fraction from S. campanulatum showed potent cytotoxicity on colon cancer cells by inducting the mitochondrial pathway of apoptosis. Extracts also showed potent inhibition of angiogenesis in several in vitro and in vivo models, by inhibiting the expression of vascular endothelial growth factor and inhibiting migration of human endothelial cells. The methanolic extract also inhibits tumor growth in xenograft tumor model with inhibition of intratumor blood vessels.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Aisha, Abdalrahim F. A.
author_facet Aisha, Abdalrahim F. A.
author_sort Aisha, Abdalrahim F. A.
title Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma
title_short Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma
title_full Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma
title_fullStr Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma
title_full_unstemmed Anti-Cancer Studies Of Garcinia Mangostana L. And Syzygium Campanulatum Korth Towards Colorectal Carcinoma
title_sort anti-cancer studies of garcinia mangostana l. and syzygium campanulatum korth towards colorectal carcinoma
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Farmasi
publishDate 2011
url http://eprints.usm.my/43187/1/ABDALRAHIM%20F.%20A.%20AISHA.pdf
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