Structural And Functional Prediction Of Hypothetical Proteins From Klebsiella Pneumoniae MGH78578: Molecular Modelling Studies

Twenty percent of the genes from Klebsiella pneumonaie MGH78578 coded for hypothetical protein. Two particular hypothetical proteins KPN00728 and KPN00729 were identified using bioinformatics approaches. Both open reading frames showed high sequence homology to succinate dehydrogenase Chain C (SdhC)...

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Main Author:	Choi, Sy Bing
Format:	Thesis
Language:	English
Published:	2011
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/43236/1/CHOI%20SY%20BING.pdf
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spelling	my-usm-ep.432362019-04-12T05:26:29Z Structural And Functional Prediction Of Hypothetical Proteins From Klebsiella Pneumoniae MGH78578: Molecular Modelling Studies 2011-10 Choi, Sy Bing RS1-441 Pharmacy and materia medica Twenty percent of the genes from Klebsiella pneumonaie MGH78578 coded for hypothetical protein. Two particular hypothetical proteins KPN00728 and KPN00729 were identified using bioinformatics approaches. Both open reading frames showed high sequence homology to succinate dehydrogenase Chain C (SdhC) and D (SdhD) from Escherichia coli KPN00729 was annotated as SdhD in May 2008. Thus, investigation on KPN00728 remained as no annotation for SdhC gene in the complete genome sequence of Klebsiella pneumoniae MGH78578. In this study, KPN00728 has a missing region with conserved residues which is important for ubiquinone (UQ) and heme group binding. Structure and function prediction of KPN00728 coupled with secondary structure analysis and transmembrane topology showed KPN00728 adopts SDH-(subunit C)-like structure. 2011-10 Thesis http://eprints.usm.my/43236/ http://eprints.usm.my/43236/1/CHOI%20SY%20BING.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Choi, Sy Bing Structural And Functional Prediction Of Hypothetical Proteins From Klebsiella Pneumoniae MGH78578: Molecular Modelling Studies
description	Twenty percent of the genes from Klebsiella pneumonaie MGH78578 coded for hypothetical protein. Two particular hypothetical proteins KPN00728 and KPN00729 were identified using bioinformatics approaches. Both open reading frames showed high sequence homology to succinate dehydrogenase Chain C (SdhC) and D (SdhD) from Escherichia coli KPN00729 was annotated as SdhD in May 2008. Thus, investigation on KPN00728 remained as no annotation for SdhC gene in the complete genome sequence of Klebsiella pneumoniae MGH78578. In this study, KPN00728 has a missing region with conserved residues which is important for ubiquinone (UQ) and heme group binding. Structure and function prediction of KPN00728 coupled with secondary structure analysis and transmembrane topology showed KPN00728 adopts SDH-(subunit C)-like structure.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Choi, Sy Bing
author_facet	Choi, Sy Bing
author_sort	Choi, Sy Bing
title	Structural And Functional Prediction Of Hypothetical Proteins From Klebsiella Pneumoniae MGH78578: Molecular Modelling Studies
title_short	Structural And Functional Prediction Of Hypothetical Proteins From Klebsiella Pneumoniae MGH78578: Molecular Modelling Studies
title_full	Structural And Functional Prediction Of Hypothetical Proteins From Klebsiella Pneumoniae MGH78578: Molecular Modelling Studies
title_fullStr	Structural And Functional Prediction Of Hypothetical Proteins From Klebsiella Pneumoniae MGH78578: Molecular Modelling Studies
title_full_unstemmed	Structural And Functional Prediction Of Hypothetical Proteins From Klebsiella Pneumoniae MGH78578: Molecular Modelling Studies
title_sort	structural and functional prediction of hypothetical proteins from klebsiella pneumoniae mgh78578: molecular modelling studies
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2011
url	http://eprints.usm.my/43236/1/CHOI%20SY%20BING.pdf
_version_	1747821183910281216

Structural And Functional Prediction Of Hypothetical Proteins From Klebsiella Pneumoniae MGH78578: Molecular Modelling Studies

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