The effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients

Objective: To determine the effects of Tualang Honey (TH) on bone mineral density (BMD) as assessed by dual energy X-ray absorptiometry (DEXA) scan when used as an adjunct to anastrazole among postmenopausal breast cancer patients. Methodology: Patients (n=33) were recruited from the Oncology Clini...

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Main Author:	Hassan, Nor Hasnina Mohd
Format:	Thesis
Language:	English
Published:	2016
Subjects:	R Medicine
Online Access:	http://eprints.usm.my/43294/1/Dr.%20Nor%20Hasnina%20Mohd%20Hassan-24%20pages.pdf
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spelling	my-usm-ep.432942019-04-12T05:25:28Z The effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients 2016 Hassan, Nor Hasnina Mohd R Medicine Objective: To determine the effects of Tualang Honey (TH) on bone mineral density (BMD) as assessed by dual energy X-ray absorptiometry (DEXA) scan when used as an adjunct to anastrazole among postmenopausal breast cancer patients. Methodology: Patients (n=33) were recruited from the Oncology Clinic, Hospital USM, Kelantan, Malaysia. The inclusion criteria included postmenopausal women with breast cancer stages I, II, or III, oestrogen receptor (ER) positive and/or progesterone receptor (PgR) positive. The patients were randomized to receive either anastrozole (1 mg) alone or anastrazole (1 mg) and TH (20 g) intervention group. Bone DEXA scan was conducted twice, at baseline (during the first visit) and six months later. Results: The T scores were significantly decreased when compared to the baseline for both femoral (−0.40 vs −0.50, p = 0.013) and the lumbar spine (−1.60 vs –1.70, p = 0.034), following six months of anastrozole alone treatment. On the other hand, there was no significant difference between the baseline and the T scores following six months of treatment for both femoral (0.35 vs. 0.50, p = 0.286) and the lumbar spine (−1.05 vs –0.95, p = 0.074) for the intervention group indicating that TH can ameliorate bone loss as a resultof anastrazole use. Administration of anastrozole significantly reduced the median femoral BMD by 2.23% and median lumbar spinal BMD by 2.84% after six months. However, in the intervention group, there was no significant change in term of both BMD and T score when compared to the baseline following six months which again indicate the potential of TH in ameliorating bone loss. Conclusions: TH has the potential to be used as an adjunct to prevent bone loss among postmenopausal breast cancer women treated with anastrozole 2016 Thesis http://eprints.usm.my/43294/ http://eprints.usm.my/43294/1/Dr.%20Nor%20Hasnina%20Mohd%20Hassan-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine
spellingShingle	R Medicine Hassan, Nor Hasnina Mohd The effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients
description	Objective: To determine the effects of Tualang Honey (TH) on bone mineral density (BMD) as assessed by dual energy X-ray absorptiometry (DEXA) scan when used as an adjunct to anastrazole among postmenopausal breast cancer patients. Methodology: Patients (n=33) were recruited from the Oncology Clinic, Hospital USM, Kelantan, Malaysia. The inclusion criteria included postmenopausal women with breast cancer stages I, II, or III, oestrogen receptor (ER) positive and/or progesterone receptor (PgR) positive. The patients were randomized to receive either anastrozole (1 mg) alone or anastrazole (1 mg) and TH (20 g) intervention group. Bone DEXA scan was conducted twice, at baseline (during the first visit) and six months later. Results: The T scores were significantly decreased when compared to the baseline for both femoral (−0.40 vs −0.50, p = 0.013) and the lumbar spine (−1.60 vs –1.70, p = 0.034), following six months of anastrozole alone treatment. On the other hand, there was no significant difference between the baseline and the T scores following six months of treatment for both femoral (0.35 vs. 0.50, p = 0.286) and the lumbar spine (−1.05 vs –0.95, p = 0.074) for the intervention group indicating that TH can ameliorate bone loss as a resultof anastrazole use. Administration of anastrozole significantly reduced the median femoral BMD by 2.23% and median lumbar spinal BMD by 2.84% after six months. However, in the intervention group, there was no significant change in term of both BMD and T score when compared to the baseline following six months which again indicate the potential of TH in ameliorating bone loss. Conclusions: TH has the potential to be used as an adjunct to prevent bone loss among postmenopausal breast cancer women treated with anastrozole
format	Thesis
qualification_level	Master's degree
author	Hassan, Nor Hasnina Mohd
author_facet	Hassan, Nor Hasnina Mohd
author_sort	Hassan, Nor Hasnina Mohd
title	The effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients
title_short	The effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients
title_full	The effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients
title_fullStr	The effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients
title_full_unstemmed	The effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients
title_sort	effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2016
url	http://eprints.usm.my/43294/1/Dr.%20Nor%20Hasnina%20Mohd%20Hassan-24%20pages.pdf
_version_	1747821194643505152

The effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients

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