The effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients

Objective: To determine the effects of Tualang Honey (TH) on bone mineral density (BMD) as assessed by dual energy X-ray absorptiometry (DEXA) scan when used as an adjunct to anastrazole among postmenopausal breast cancer patients. Methodology: Patients (n=33) were recruited from the Oncology Clini...

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主要作者: Hassan, Nor Hasnina Mohd
格式: Thesis
語言:English
出版: 2016
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spelling my-usm-ep.432942019-04-12T05:25:28Z The effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients 2016 Hassan, Nor Hasnina Mohd R Medicine Objective: To determine the effects of Tualang Honey (TH) on bone mineral density (BMD) as assessed by dual energy X-ray absorptiometry (DEXA) scan when used as an adjunct to anastrazole among postmenopausal breast cancer patients. Methodology: Patients (n=33) were recruited from the Oncology Clinic, Hospital USM, Kelantan, Malaysia. The inclusion criteria included postmenopausal women with breast cancer stages I, II, or III, oestrogen receptor (ER) positive and/or progesterone receptor (PgR) positive. The patients were randomized to receive either anastrozole (1 mg) alone or anastrazole (1 mg) and TH (20 g) intervention group. Bone DEXA scan was conducted twice, at baseline (during the first visit) and six months later. Results: The T scores were significantly decreased when compared to the baseline for both femoral (−0.40 vs −0.50, p = 0.013) and the lumbar spine (−1.60 vs –1.70, p = 0.034), following six months of anastrozole alone treatment. On the other hand, there was no significant difference between the baseline and the T scores following six months of treatment for both femoral (0.35 vs. 0.50, p = 0.286) and the lumbar spine (−1.05 vs –0.95, p = 0.074) for the intervention group indicating that TH can ameliorate bone loss as a resultof anastrazole use. Administration of anastrozole significantly reduced the median femoral BMD by 2.23% and median lumbar spinal BMD by 2.84% after six months. However, in the intervention group, there was no significant change in term of both BMD and T score when compared to the baseline following six months which again indicate the potential of TH in ameliorating bone loss. Conclusions: TH has the potential to be used as an adjunct to prevent bone loss among postmenopausal breast cancer women treated with anastrozole 2016 Thesis http://eprints.usm.my/43294/ http://eprints.usm.my/43294/1/Dr.%20Nor%20Hasnina%20Mohd%20Hassan-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic R Medicine
spellingShingle R Medicine
Hassan, Nor Hasnina Mohd
The effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients
description Objective: To determine the effects of Tualang Honey (TH) on bone mineral density (BMD) as assessed by dual energy X-ray absorptiometry (DEXA) scan when used as an adjunct to anastrazole among postmenopausal breast cancer patients. Methodology: Patients (n=33) were recruited from the Oncology Clinic, Hospital USM, Kelantan, Malaysia. The inclusion criteria included postmenopausal women with breast cancer stages I, II, or III, oestrogen receptor (ER) positive and/or progesterone receptor (PgR) positive. The patients were randomized to receive either anastrozole (1 mg) alone or anastrazole (1 mg) and TH (20 g) intervention group. Bone DEXA scan was conducted twice, at baseline (during the first visit) and six months later. Results: The T scores were significantly decreased when compared to the baseline for both femoral (−0.40 vs −0.50, p = 0.013) and the lumbar spine (−1.60 vs –1.70, p = 0.034), following six months of anastrozole alone treatment. On the other hand, there was no significant difference between the baseline and the T scores following six months of treatment for both femoral (0.35 vs. 0.50, p = 0.286) and the lumbar spine (−1.05 vs –0.95, p = 0.074) for the intervention group indicating that TH can ameliorate bone loss as a resultof anastrazole use. Administration of anastrozole significantly reduced the median femoral BMD by 2.23% and median lumbar spinal BMD by 2.84% after six months. However, in the intervention group, there was no significant change in term of both BMD and T score when compared to the baseline following six months which again indicate the potential of TH in ameliorating bone loss. Conclusions: TH has the potential to be used as an adjunct to prevent bone loss among postmenopausal breast cancer women treated with anastrozole
format Thesis
qualification_level Master's degree
author Hassan, Nor Hasnina Mohd
author_facet Hassan, Nor Hasnina Mohd
author_sort Hassan, Nor Hasnina Mohd
title The effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients
title_short The effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients
title_full The effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients
title_fullStr The effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients
title_full_unstemmed The effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients
title_sort effects of tualang honey on bone mineral density as an adjuvant therapy to anastrozole among postmenopausal breast cancer patients
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Perubatan
publishDate 2016
url http://eprints.usm.my/43294/1/Dr.%20Nor%20Hasnina%20Mohd%20Hassan-24%20pages.pdf
_version_ 1747821194643505152