Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules

Dengue infection is re-emerging as a major global disease and is classified as a Category A priority pathogen. Dengue viruses are estimated to infect 50-100 million people annually and are considered to cause one of the most important arthropod-borne viral diseases in terms of human morbidity and mo...

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Main Author:	Ab Aziz, Nurohaida
Format:	Thesis
Language:	English
Published:	2011
Subjects:	QH1 Natural history (General - Including nature conservation geographical distribution)
Online Access:	http://eprints.usm.my/43456/1/NUROHAIDA%20AB%20AZIZ.pdf
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id	my-usm-ep.43456
record_format	uketd_dc
spelling	my-usm-ep.434562019-04-12T05:26:31Z Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules 2011-08 Ab Aziz, Nurohaida QH1 Natural history (General - Including nature conservation, geographical distribution) Dengue infection is re-emerging as a major global disease and is classified as a Category A priority pathogen. Dengue viruses are estimated to infect 50-100 million people annually and are considered to cause one of the most important arthropod-borne viral diseases in terms of human morbidity and mortality. Virus transmission occurs through the bite of the Aedes aegypti mosquito and half the world’s population is at risk for infection. There is presently no approved vaccine or antiviral drug that is effective against dengue viruses. The focus of this thesis is to combine the power of high performance computing with wet lab experiments for the recombinant NS3 serine protease from dengue virus type 2 as a screen for antiviral small molecules that can be used either to prevent or treat dengue virus infections. 2011-08 Thesis http://eprints.usm.my/43456/ http://eprints.usm.my/43456/1/NUROHAIDA%20AB%20AZIZ.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Kajihayat
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QH1 Natural history (General - Including nature conservation geographical distribution)
spellingShingle	QH1 Natural history (General - Including nature conservation geographical distribution) Ab Aziz, Nurohaida Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules
description	Dengue infection is re-emerging as a major global disease and is classified as a Category A priority pathogen. Dengue viruses are estimated to infect 50-100 million people annually and are considered to cause one of the most important arthropod-borne viral diseases in terms of human morbidity and mortality. Virus transmission occurs through the bite of the Aedes aegypti mosquito and half the world’s population is at risk for infection. There is presently no approved vaccine or antiviral drug that is effective against dengue viruses. The focus of this thesis is to combine the power of high performance computing with wet lab experiments for the recombinant NS3 serine protease from dengue virus type 2 as a screen for antiviral small molecules that can be used either to prevent or treat dengue virus infections.
format	Thesis
qualification_level	Master's degree
author	Ab Aziz, Nurohaida
author_facet	Ab Aziz, Nurohaida
author_sort	Ab Aziz, Nurohaida
title	Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules
title_short	Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules
title_full	Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules
title_fullStr	Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules
title_full_unstemmed	Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules
title_sort	recombinant ns3 serine protease from dengue virus 2 as a screen for small molecules
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kajihayat
publishDate	2011
url	http://eprints.usm.my/43456/1/NUROHAIDA%20AB%20AZIZ.pdf
_version_	1747821218083373056

Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules

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