Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line
In this present study, the equimolar complexes of vancomycin, a broad-spectrum glycopeptide antibiotic with β-CD were prepared to evaluate their suitability for the development of a prolonged-release form of the antibiotic. β-CD/vancomycin complexes were prepared accordingly via freeze-drying and kn...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English |
| Published: |
2011
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| Subjects: | |
| Online Access: | http://eprints.usm.my/43531/1/ZARIF%20MOHAMED%20SOFIAN.pdf |
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| Summary: | In this present study, the equimolar complexes of vancomycin, a broad-spectrum glycopeptide antibiotic with β-CD were prepared to evaluate their suitability for the development of a prolonged-release form of the antibiotic. β-CD/vancomycin complexes were prepared accordingly via freeze-drying and kneading techniques. The formation of the complexes was confirmed through X-ray Diffractometry (XRD), Thermogravimetric Analysis (TGA), Scanning Electron Microscopy (SEM) and Fourier Transfrom Infrared Spectroscopy (FT-IR). The results obtained were all in good agreement suggesting the successive formation of the aforementioned binary systems. |
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