Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line

Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line

In this present study, the equimolar complexes of vancomycin, a broad-spectrum glycopeptide antibiotic with β-CD were prepared to evaluate their suitability for the development of a prolonged-release form of the antibiotic. β-CD/vancomycin complexes were prepared accordingly via freeze-drying and kn...

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Main Author: SOFIAN, ZARIF MOHAMED
Format: Thesis
Language:English
Published: 2011
Subjects:
R5-920 Medicine (General)
Online Access:http://eprints.usm.my/43531/1/ZARIF%20MOHAMED%20SOFIAN.pdf
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spelling my-usm-ep.435312019-04-12T05:26:33Z Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line 2011-06 SOFIAN, ZARIF MOHAMED R5-920 Medicine (General) In this present study, the equimolar complexes of vancomycin, a broad-spectrum glycopeptide antibiotic with β-CD were prepared to evaluate their suitability for the development of a prolonged-release form of the antibiotic. β-CD/vancomycin complexes were prepared accordingly via freeze-drying and kneading techniques. The formation of the complexes was confirmed through X-ray Diffractometry (XRD), Thermogravimetric Analysis (TGA), Scanning Electron Microscopy (SEM) and Fourier Transfrom Infrared Spectroscopy (FT-IR). The results obtained were all in good agreement suggesting the successive formation of the aforementioned binary systems. 2011-06 Thesis http://eprints.usm.my/43531/ http://eprints.usm.my/43531/1/ZARIF%20MOHAMED%20SOFIAN.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic R5-920 Medicine (General)
spellingShingle R5-920 Medicine (General)
SOFIAN, ZARIF MOHAMED
Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line
description In this present study, the equimolar complexes of vancomycin, a broad-spectrum glycopeptide antibiotic with β-CD were prepared to evaluate their suitability for the development of a prolonged-release form of the antibiotic. β-CD/vancomycin complexes were prepared accordingly via freeze-drying and kneading techniques. The formation of the complexes was confirmed through X-ray Diffractometry (XRD), Thermogravimetric Analysis (TGA), Scanning Electron Microscopy (SEM) and Fourier Transfrom Infrared Spectroscopy (FT-IR). The results obtained were all in good agreement suggesting the successive formation of the aforementioned binary systems.
format Thesis
qualification_level Master's degree
author SOFIAN, ZARIF MOHAMED
author_facet SOFIAN, ZARIF MOHAMED
author_sort SOFIAN, ZARIF MOHAMED
title Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line
title_short Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line
title_full Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line
title_fullStr Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line
title_full_unstemmed Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line
title_sort vancomycin and its beta-cyclodextrin complex: physicochemical characterization and its cytotoxicity evaluation on human glial cell line
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Perubatan
publishDate 2011
url http://eprints.usm.my/43531/1/ZARIF%20MOHAMED%20SOFIAN.pdf
_version_ 1747821234688622592

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