Bioactives From Probiotic For Dermal Health Upon Physical Treatments

Lactobacilli and bifidobacteria are the most common genera of probiotics with documented potentials on gut health. Recent studies suggested that such potentials can be extended beyond gut well-being, such as that of dermal health. This study was aimed to evaluate the production of bioactives t...

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Main Author:	Lew, Lee Ching
Format:	Thesis
Language:	English
Published:	2013
Subjects:	T11.95-12.5 Industrial directories
Online Access:	http://eprints.usm.my/43569/1/Lew%20Lee%20Ching24.pdf
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id	my-usm-ep.43569
record_format	uketd_dc
spelling	my-usm-ep.435692019-04-12T05:26:18Z Bioactives From Probiotic For Dermal Health Upon Physical Treatments 2013-01 Lew, Lee Ching T11.95-12.5 Industrial directories Lactobacilli and bifidobacteria are the most common genera of probiotics with documented potentials on gut health. Recent studies suggested that such potentials can be extended beyond gut well-being, such as that of dermal health. This study was aimed to evaluate the production of bioactives that are essential for skin health from either lactobacilli or bifidobacteria grown in milk. Lipoteichoic acid content in the cell wall fraction was higher (P < 0.05) in Lactobacillus rhamnosus FTDC 8313 and Bifidobacterium longum BL 8643 compared to the other strains studied. Meanwhile, all strains studied showed equal concentration of cell wall peptidoglycan. Our results showed that lactobacilli produced higher concentration of hyaluronic acid and diacetyl than bifidobacteria. Strains of lactobacilli and bifidobacteria studied also produced acid and neutral sphingomyelinase (SMase), enzymes that generate ceramides which subsequently play important roles in development of physical barriers in the stratum corneum (SC). Sphingomyelinase activity in L. rhamnosus FTDC 8313 was also optimized using divalent metal ions via response surface methodology. Using a full-factorial design for factors screening, only magnesium sulphate (MgSO4) and manganese sulphate (MnSO4) significantly (P < 0.001) influenced SMase activity while the effects of calcium sulphate (CaSO4) was insignificant (P > 0.05). 2013-01 Thesis http://eprints.usm.my/43569/ http://eprints.usm.my/43569/1/Lew%20Lee%20Ching24.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Teknologi Industri
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	T11.95-12.5 Industrial directories
spellingShingle	T11.95-12.5 Industrial directories Lew, Lee Ching Bioactives From Probiotic For Dermal Health Upon Physical Treatments
description	Lactobacilli and bifidobacteria are the most common genera of probiotics with documented potentials on gut health. Recent studies suggested that such potentials can be extended beyond gut well-being, such as that of dermal health. This study was aimed to evaluate the production of bioactives that are essential for skin health from either lactobacilli or bifidobacteria grown in milk. Lipoteichoic acid content in the cell wall fraction was higher (P < 0.05) in Lactobacillus rhamnosus FTDC 8313 and Bifidobacterium longum BL 8643 compared to the other strains studied. Meanwhile, all strains studied showed equal concentration of cell wall peptidoglycan. Our results showed that lactobacilli produced higher concentration of hyaluronic acid and diacetyl than bifidobacteria. Strains of lactobacilli and bifidobacteria studied also produced acid and neutral sphingomyelinase (SMase), enzymes that generate ceramides which subsequently play important roles in development of physical barriers in the stratum corneum (SC). Sphingomyelinase activity in L. rhamnosus FTDC 8313 was also optimized using divalent metal ions via response surface methodology. Using a full-factorial design for factors screening, only magnesium sulphate (MgSO4) and manganese sulphate (MnSO4) significantly (P < 0.001) influenced SMase activity while the effects of calcium sulphate (CaSO4) was insignificant (P > 0.05).
format	Thesis
qualification_level	Master's degree
author	Lew, Lee Ching
author_facet	Lew, Lee Ching
author_sort	Lew, Lee Ching
title	Bioactives From Probiotic For Dermal Health Upon Physical Treatments
title_short	Bioactives From Probiotic For Dermal Health Upon Physical Treatments
title_full	Bioactives From Probiotic For Dermal Health Upon Physical Treatments
title_fullStr	Bioactives From Probiotic For Dermal Health Upon Physical Treatments
title_full_unstemmed	Bioactives From Probiotic For Dermal Health Upon Physical Treatments
title_sort	bioactives from probiotic for dermal health upon physical treatments
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Teknologi Industri
publishDate	2013
url	http://eprints.usm.my/43569/1/Lew%20Lee%20Ching24.pdf
_version_	1747821238362832896

Bioactives From Probiotic For Dermal Health Upon Physical Treatments

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