Survival rate and prognostic factors of Ewing Family Tumor in paediatric patients (a 11-year review) in Hospital USM from 2002-2012

Introduction Ewing Family Tumor (EFT) is a very malignant and aggressive tumor. It was very rare tumor especially in Asia compare to western countries. During the past three decades, the prognosis of patient with EFT had improves considerably as shown in several clinical trials, mainly because o...

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Main Author:	Adenam, Norhaila Mohamad
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RC Internal medicine
Online Access:	http://eprints.usm.my/43753/1/Dr.%20Norhaila%20Mohamad%20Adenam-24%20pages.pdf
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id	my-usm-ep.43753
record_format	uketd_dc
spelling	my-usm-ep.437532019-04-12T05:25:28Z Survival rate and prognostic factors of Ewing Family Tumor in paediatric patients (a 11-year review) in Hospital USM from 2002-2012 2016 Adenam, Norhaila Mohamad RC Internal medicine Introduction Ewing Family Tumor (EFT) is a very malignant and aggressive tumor. It was very rare tumor especially in Asia compare to western countries. During the past three decades, the prognosis of patient with EFT had improves considerably as shown in several clinical trials, mainly because of improved chemotherapy regimes. In our country, there is lack of reports in the treatment outcome and survival of children with EFT. There is no published study predicting the treatment outcome in Hospital USM at present. Objectives The objectives of this study were to evaluate the Overall Survival (OS) and Event Free Survival (EFS) rate of patients who were diagnosed with EFT. We want to evaluate the demographic data and identify the possible predictive factors that determine the EFS and OS rate of those children with EFT and treated in Hospital USM. Methodology This is a retrospective record review of children aged 0-18 years with EFT. Children were identified from registration data in Oncology Unit and medical records from Record Office HUSM. In case of uncontactable or deceased patients, a letter was sent to State Registry to obtain the end result/outcome of the patients. The associations of demographic and clinical factors with patients outcome were determined by Cox regression. Survival curves were estimated by the Kaplan-Meier method and compared by the Log-rank test. Results There were 51 patients identified from the registration but then only 29 children were enrolled in this study, which full filled all the inclusion criteria. The mean duration follow up was 21 months. The OS rate at 1, 2, 3 and 5 years were 62.1%, 44.8%, 30.2% and 21.6% respectively. The EFS rate at 1, 2, 3 and 5 years were 41.9%, 26.7%, 17.8% and 0% respectively. Multivariate Cox regression analysis showed that presence of surgical intervention (p=0.030) and major complications (p=0.045) were significant prognostic factors to the survival of EFT in this study. Conclusion Survival rate among our patients was comparable to other developing countries. However we are far away if compared to developed countries as the survival rate only achieved almost half from their survival rate. We are able to identify two significant independent prognostic factors to the survival for EFT in our patients which were surgical intervention and presence of major complications. 2016 Thesis http://eprints.usm.my/43753/ http://eprints.usm.my/43753/1/Dr.%20Norhaila%20Mohamad%20Adenam-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Adenam, Norhaila Mohamad Survival rate and prognostic factors of Ewing Family Tumor in paediatric patients (a 11-year review) in Hospital USM from 2002-2012
description	Introduction Ewing Family Tumor (EFT) is a very malignant and aggressive tumor. It was very rare tumor especially in Asia compare to western countries. During the past three decades, the prognosis of patient with EFT had improves considerably as shown in several clinical trials, mainly because of improved chemotherapy regimes. In our country, there is lack of reports in the treatment outcome and survival of children with EFT. There is no published study predicting the treatment outcome in Hospital USM at present. Objectives The objectives of this study were to evaluate the Overall Survival (OS) and Event Free Survival (EFS) rate of patients who were diagnosed with EFT. We want to evaluate the demographic data and identify the possible predictive factors that determine the EFS and OS rate of those children with EFT and treated in Hospital USM. Methodology This is a retrospective record review of children aged 0-18 years with EFT. Children were identified from registration data in Oncology Unit and medical records from Record Office HUSM. In case of uncontactable or deceased patients, a letter was sent to State Registry to obtain the end result/outcome of the patients. The associations of demographic and clinical factors with patients outcome were determined by Cox regression. Survival curves were estimated by the Kaplan-Meier method and compared by the Log-rank test. Results There were 51 patients identified from the registration but then only 29 children were enrolled in this study, which full filled all the inclusion criteria. The mean duration follow up was 21 months. The OS rate at 1, 2, 3 and 5 years were 62.1%, 44.8%, 30.2% and 21.6% respectively. The EFS rate at 1, 2, 3 and 5 years were 41.9%, 26.7%, 17.8% and 0% respectively. Multivariate Cox regression analysis showed that presence of surgical intervention (p=0.030) and major complications (p=0.045) were significant prognostic factors to the survival of EFT in this study. Conclusion Survival rate among our patients was comparable to other developing countries. However we are far away if compared to developed countries as the survival rate only achieved almost half from their survival rate. We are able to identify two significant independent prognostic factors to the survival for EFT in our patients which were surgical intervention and presence of major complications.
format	Thesis
qualification_level	Master's degree
author	Adenam, Norhaila Mohamad
author_facet	Adenam, Norhaila Mohamad
author_sort	Adenam, Norhaila Mohamad
title	Survival rate and prognostic factors of Ewing Family Tumor in paediatric patients (a 11-year review) in Hospital USM from 2002-2012
title_short	Survival rate and prognostic factors of Ewing Family Tumor in paediatric patients (a 11-year review) in Hospital USM from 2002-2012
title_full	Survival rate and prognostic factors of Ewing Family Tumor in paediatric patients (a 11-year review) in Hospital USM from 2002-2012
title_fullStr	Survival rate and prognostic factors of Ewing Family Tumor in paediatric patients (a 11-year review) in Hospital USM from 2002-2012
title_full_unstemmed	Survival rate and prognostic factors of Ewing Family Tumor in paediatric patients (a 11-year review) in Hospital USM from 2002-2012
title_sort	survival rate and prognostic factors of ewing family tumor in paediatric patients (a 11-year review) in hospital usm from 2002-2012
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2016
url	http://eprints.usm.my/43753/1/Dr.%20Norhaila%20Mohamad%20Adenam-24%20pages.pdf
_version_	1747821271783047168

Survival rate and prognostic factors of Ewing Family Tumor in paediatric patients (a 11-year review) in Hospital USM from 2002-2012

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