Neostigmine infusion versus syrup lactulose for the treatment of constipation in Intensive Care Unit (ICU) : a randomized, controlled study

Introduction Constipation and its implications have received very little attention even though this gastrointestinal motility disorders are common in critically ill patients. Constipation is defined as failure of the bowel to open for 3 consecutive days. This condition can give rise few adverse...

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Main Author:	Suhaimi, Norlida
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RC799-869 Diseases of the digestive system Gastroenterology
Online Access:	http://eprints.usm.my/43762/1/Dr.%20Norlida%20Suhaimi-24%20pages.pdf
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spelling	my-usm-ep.437622019-04-12T05:25:21Z Neostigmine infusion versus syrup lactulose for the treatment of constipation in Intensive Care Unit (ICU) : a randomized, controlled study 2016-05 Suhaimi, Norlida RC799-869 Diseases of the digestive system. Gastroenterology Introduction Constipation and its implications have received very little attention even though this gastrointestinal motility disorders are common in critically ill patients. Constipation is defined as failure of the bowel to open for 3 consecutive days. This condition can give rise few adverse implications in critically ill patients such as more constipated patient failed to wean from mechanical ventilation, the median length of stay in intensive care increase and the proportion of enteral feeding intolerance were greater than non-constipated patients. Objectives To compare bowel opening between groups of patients who receive neostigmine infusion versus syrup lactulose for treatment of constipation in ICU. Methodology This is a prospective study. The ventilated patients who fulfilled the inclusion criteria and were admitted to HUSM ICU between February till October 2015 were randomly received either neostigmine infusions 0.4 – 0.8 mg/hour or syrup lactulose 15 mls TDS. Incidence of bowel opening, time to first bowel opening and any adverse reactions were recorded. Results 40 patients were randomized where 20 patients in each group either neostigmine infusion or syrup lactulose. Neostigmine infusion group significantly had bowel opening (pvalue= 0.027) and markedly had faster onset of bowel opening (p-value<0.001) compared to syrup lactulose group. There was no significant mean different in term of length of mechanical ventilation between two group of therapy (p-value=0.542). No complications occurred from the neostigmine infusion. Conclusion Neostigmine infusion was effective for treatment of constipation in ICU compared than standard therapy syrup lactulose. Continuous intravenous neostigmine infusion of up to 0.8 mg / hour to critically ill patients appears to be safe. 2016-05 Thesis http://eprints.usm.my/43762/ http://eprints.usm.my/43762/1/Dr.%20Norlida%20Suhaimi-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC799-869 Diseases of the digestive system Gastroenterology
spellingShingle	RC799-869 Diseases of the digestive system Gastroenterology Suhaimi, Norlida Neostigmine infusion versus syrup lactulose for the treatment of constipation in Intensive Care Unit (ICU) : a randomized, controlled study
description	Introduction Constipation and its implications have received very little attention even though this gastrointestinal motility disorders are common in critically ill patients. Constipation is defined as failure of the bowel to open for 3 consecutive days. This condition can give rise few adverse implications in critically ill patients such as more constipated patient failed to wean from mechanical ventilation, the median length of stay in intensive care increase and the proportion of enteral feeding intolerance were greater than non-constipated patients. Objectives To compare bowel opening between groups of patients who receive neostigmine infusion versus syrup lactulose for treatment of constipation in ICU. Methodology This is a prospective study. The ventilated patients who fulfilled the inclusion criteria and were admitted to HUSM ICU between February till October 2015 were randomly received either neostigmine infusions 0.4 – 0.8 mg/hour or syrup lactulose 15 mls TDS. Incidence of bowel opening, time to first bowel opening and any adverse reactions were recorded. Results 40 patients were randomized where 20 patients in each group either neostigmine infusion or syrup lactulose. Neostigmine infusion group significantly had bowel opening (pvalue= 0.027) and markedly had faster onset of bowel opening (p-value<0.001) compared to syrup lactulose group. There was no significant mean different in term of length of mechanical ventilation between two group of therapy (p-value=0.542). No complications occurred from the neostigmine infusion. Conclusion Neostigmine infusion was effective for treatment of constipation in ICU compared than standard therapy syrup lactulose. Continuous intravenous neostigmine infusion of up to 0.8 mg / hour to critically ill patients appears to be safe.
format	Thesis
qualification_level	Master's degree
author	Suhaimi, Norlida
author_facet	Suhaimi, Norlida
author_sort	Suhaimi, Norlida
title	Neostigmine infusion versus syrup lactulose for the treatment of constipation in Intensive Care Unit (ICU) : a randomized, controlled study
title_short	Neostigmine infusion versus syrup lactulose for the treatment of constipation in Intensive Care Unit (ICU) : a randomized, controlled study
title_full	Neostigmine infusion versus syrup lactulose for the treatment of constipation in Intensive Care Unit (ICU) : a randomized, controlled study
title_fullStr	Neostigmine infusion versus syrup lactulose for the treatment of constipation in Intensive Care Unit (ICU) : a randomized, controlled study
title_full_unstemmed	Neostigmine infusion versus syrup lactulose for the treatment of constipation in Intensive Care Unit (ICU) : a randomized, controlled study
title_sort	neostigmine infusion versus syrup lactulose for the treatment of constipation in intensive care unit (icu) : a randomized, controlled study
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2016
url	http://eprints.usm.my/43762/1/Dr.%20Norlida%20Suhaimi-24%20pages.pdf
_version_	1747821273978765312

Neostigmine infusion versus syrup lactulose for the treatment of constipation in Intensive Care Unit (ICU) : a randomized, controlled study

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