Comparison of macular thickness, retinal nerve fiber layer thickness and optic nerve head parameters in HbE/Beta thalassemia and control

Introduction HbE/ β-thalassemia is one of the hemoglobinopathy that commonly found in South East Asia (SEA) and it has become a severe public health problem today. Apart from the pathological anemia, they also share other common features like hepatosplenomegaly and craniofacial bony deformities....

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Main Author:	Dezhao, Sai
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RE Ophthalmology
Online Access:	http://eprints.usm.my/43965/1/Dr.%20Sai%20Dezhao-24%20pages.pdf
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spelling	my-usm-ep.439652019-04-12T05:25:28Z Comparison of macular thickness, retinal nerve fiber layer thickness and optic nerve head parameters in HbE/Beta thalassemia and control 2016 Dezhao, Sai RE Ophthalmology Introduction HbE/ β-thalassemia is one of the hemoglobinopathy that commonly found in South East Asia (SEA) and it has become a severe public health problem today. Apart from the pathological anemia, they also share other common features like hepatosplenomegaly and craniofacial bony deformities. Ocular biometry can be affected as well due to abnormal growth of the orbital bone. Other than these, structure of the retina and the optic nerve may be altered in these patients. Objective To compare mean macular thickness, retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) parameters between HbE/ β-thalassemia group and control. Methods This is a cross-sectional study conducted in Hospital Universiti Sains Malaysia from June 2014 till March 2016. Patients with confirmed HbE/ β-thalassemia and healthy population were selected based on the inclusion and exclusion criteria. Baseline macular thickness, RNFL thickness and ONH parameters were measured by using Cirrus HD-OCT. Statistical analysis was performed using SPSS version 22.0. Results A total of 132 participants were recruited (66 participants in HbE/ β-thalassemia group and 66 participants in control). There was no significant difference in mean macular thickness in between the two groups. No significant different found in the mean RNFL thickness in between HbE/ β- thalassemia and control. There was also no significant difference in ONH parameters between two groups. Conclusion The study revealed that there was no significant differences in both mean macular thickness, RNFL thickness and ONH parameters in between HbE/ β-thalassemia and normal population. 2016 Thesis http://eprints.usm.my/43965/ http://eprints.usm.my/43965/1/Dr.%20Sai%20Dezhao-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RE Ophthalmology
spellingShingle	RE Ophthalmology Dezhao, Sai Comparison of macular thickness, retinal nerve fiber layer thickness and optic nerve head parameters in HbE/Beta thalassemia and control
description	Introduction HbE/ β-thalassemia is one of the hemoglobinopathy that commonly found in South East Asia (SEA) and it has become a severe public health problem today. Apart from the pathological anemia, they also share other common features like hepatosplenomegaly and craniofacial bony deformities. Ocular biometry can be affected as well due to abnormal growth of the orbital bone. Other than these, structure of the retina and the optic nerve may be altered in these patients. Objective To compare mean macular thickness, retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) parameters between HbE/ β-thalassemia group and control. Methods This is a cross-sectional study conducted in Hospital Universiti Sains Malaysia from June 2014 till March 2016. Patients with confirmed HbE/ β-thalassemia and healthy population were selected based on the inclusion and exclusion criteria. Baseline macular thickness, RNFL thickness and ONH parameters were measured by using Cirrus HD-OCT. Statistical analysis was performed using SPSS version 22.0. Results A total of 132 participants were recruited (66 participants in HbE/ β-thalassemia group and 66 participants in control). There was no significant difference in mean macular thickness in between the two groups. No significant different found in the mean RNFL thickness in between HbE/ β- thalassemia and control. There was also no significant difference in ONH parameters between two groups. Conclusion The study revealed that there was no significant differences in both mean macular thickness, RNFL thickness and ONH parameters in between HbE/ β-thalassemia and normal population.
format	Thesis
qualification_level	Master's degree
author	Dezhao, Sai
author_facet	Dezhao, Sai
author_sort	Dezhao, Sai
title	Comparison of macular thickness, retinal nerve fiber layer thickness and optic nerve head parameters in HbE/Beta thalassemia and control
title_short	Comparison of macular thickness, retinal nerve fiber layer thickness and optic nerve head parameters in HbE/Beta thalassemia and control
title_full	Comparison of macular thickness, retinal nerve fiber layer thickness and optic nerve head parameters in HbE/Beta thalassemia and control
title_fullStr	Comparison of macular thickness, retinal nerve fiber layer thickness and optic nerve head parameters in HbE/Beta thalassemia and control
title_full_unstemmed	Comparison of macular thickness, retinal nerve fiber layer thickness and optic nerve head parameters in HbE/Beta thalassemia and control
title_sort	comparison of macular thickness, retinal nerve fiber layer thickness and optic nerve head parameters in hbe/beta thalassemia and control
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2016
url	http://eprints.usm.my/43965/1/Dr.%20Sai%20Dezhao-24%20pages.pdf
_version_	1747821311363645440

Comparison of macular thickness, retinal nerve fiber layer thickness and optic nerve head parameters in HbE/Beta thalassemia and control

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