Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia

Repeated Pregnancy Loss (RPL) is a prevalent condition where conventional hereditary thrombophilia factors have been ruled out in Malaysia population. M2/ANXA5 haplotype, a variation at the core promoter region of Annexin A5 (ANXA5) gene, was suggested to be a predisposition factor for RPL. ANXA5 is...

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Main Author:	Ang, Kai Cheen
Format:	Thesis
Language:	English
Published:	2018
Subjects:	R5-920 Medicine (General)
Online Access:	http://eprints.usm.my/44014/1/ANG%20KAI%20CHEEN.pdf
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id	my-usm-ep.44014
record_format	uketd_dc
spelling	my-usm-ep.440142019-04-12T05:24:50Z Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia 2018-06 Ang, Kai Cheen R5-920 Medicine (General) Repeated Pregnancy Loss (RPL) is a prevalent condition where conventional hereditary thrombophilia factors have been ruled out in Malaysia population. M2/ANXA5 haplotype, a variation at the core promoter region of Annexin A5 (ANXA5) gene, was suggested to be a predisposition factor for RPL. ANXA5 is a placenta anticoagulant protein which binds on the surface of syncitiotrophoblasts to prevent thrombotic events that would lead to RPL. In this study, the prevalence of M2/ANXA5 haplotype was 42.2% in Malay population and 34.9% for parous controls. When compared M2/ANXA5 clinically defined primary and secondary RPL carriers to M2/ANXA5 carriers in random populations, odds ratio of 1.52 (95% CI:1.1 to 2.1) was determined. 2018-06 Thesis http://eprints.usm.my/44014/ http://eprints.usm.my/44014/1/ANG%20KAI%20CHEEN.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R5-920 Medicine (General)
spellingShingle	R5-920 Medicine (General) Ang, Kai Cheen Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia
description	Repeated Pregnancy Loss (RPL) is a prevalent condition where conventional hereditary thrombophilia factors have been ruled out in Malaysia population. M2/ANXA5 haplotype, a variation at the core promoter region of Annexin A5 (ANXA5) gene, was suggested to be a predisposition factor for RPL. ANXA5 is a placenta anticoagulant protein which binds on the surface of syncitiotrophoblasts to prevent thrombotic events that would lead to RPL. In this study, the prevalence of M2/ANXA5 haplotype was 42.2% in Malay population and 34.9% for parous controls. When compared M2/ANXA5 clinically defined primary and secondary RPL carriers to M2/ANXA5 carriers in random populations, odds ratio of 1.52 (95% CI:1.1 to 2.1) was determined.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Ang, Kai Cheen
author_facet	Ang, Kai Cheen
author_sort	Ang, Kai Cheen
title	Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia
title_short	Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia
title_full	Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia
title_fullStr	Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia
title_full_unstemmed	Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia
title_sort	genetic predisposition of m2 annexin a5 haplotype in recurrent pregnancy loss among the malays in malaysia
granting_institution	Universiti Sains Malaysia
granting_department	Institut Perubatan & Pergigian Termaju
publishDate	2018
url	http://eprints.usm.my/44014/1/ANG%20KAI%20CHEEN.pdf
_version_	1747821319414611968

Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia

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