Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models

Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models

β-carboline is known for its numerous traditional uses and has been widely investigated for various health indications. In particular, recently β-carboline has shown some promising findings in the field of anticancer. Hence this study investigates the potential anticancer activity of β-carboline com...

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Main Author: Kamaruzaman, Nur Azzalia
Format: Thesis
Language:English
Published: 2018
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/44126/1/NUR%20AZZALIA%20KAMARUZAMAN.pdf
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spelling my-usm-ep.441262019-04-18T02:42:55Z Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models 2018-04 Kamaruzaman, Nur Azzalia RS1-441 Pharmacy and materia medica β-carboline is known for its numerous traditional uses and has been widely investigated for various health indications. In particular, recently β-carboline has shown some promising findings in the field of anticancer. Hence this study investigates the potential anticancer activity of β-carboline compounds using in vitro models. Thirty synthesized β-carboline compounds were tested using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for anticancer activity and selectivity index (SI) against four human cancer (colon HT-29, cervical HeLa, liver Hep G2 and leukemia K562) and two non-cancer (mouse embryo fibroblasts BALB/c3T3 and human foreskin fibroblasts Hs27) cell lines. 2018-04 Thesis http://eprints.usm.my/44126/ http://eprints.usm.my/44126/1/NUR%20AZZALIA%20KAMARUZAMAN.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Penyelidikan Dadah dan Ubat-ubatan
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Kamaruzaman, Nur Azzalia
Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models
description β-carboline is known for its numerous traditional uses and has been widely investigated for various health indications. In particular, recently β-carboline has shown some promising findings in the field of anticancer. Hence this study investigates the potential anticancer activity of β-carboline compounds using in vitro models. Thirty synthesized β-carboline compounds were tested using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for anticancer activity and selectivity index (SI) against four human cancer (colon HT-29, cervical HeLa, liver Hep G2 and leukemia K562) and two non-cancer (mouse embryo fibroblasts BALB/c3T3 and human foreskin fibroblasts Hs27) cell lines.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Kamaruzaman, Nur Azzalia
author_facet Kamaruzaman, Nur Azzalia
author_sort Kamaruzaman, Nur Azzalia
title Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models
title_short Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models
title_full Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models
title_fullStr Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models
title_full_unstemmed Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models
title_sort apoptosis and genotoxicity of selected β-carboline compounds against chronic myelogenous leukemia using in vitro experimental models
granting_institution Universiti Sains Malaysia
granting_department Pusat Penyelidikan Dadah dan Ubat-ubatan
publishDate 2018
url http://eprints.usm.my/44126/1/NUR%20AZZALIA%20KAMARUZAMAN.pdf
_version_ 1747821332640301056

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