Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats
Mitragyna speciosa (M. speciosa) Korth is a traditional herbal plant indigenous to Southeast Asia. Regular use of this plant by human may lead to addiction with profound withdrawal symptoms. It is hypothesized that the abuse of M. speciosa preparations could be attributed to mitragynine, the main ps...
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2018
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my-usm-ep.441272019-04-18T02:47:15Z Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats 2018-05 Yusoff, Nurul Hasnida Mohammad RS1-441 Pharmacy and materia medica Mitragyna speciosa (M. speciosa) Korth is a traditional herbal plant indigenous to Southeast Asia. Regular use of this plant by human may lead to addiction with profound withdrawal symptoms. It is hypothesized that the abuse of M. speciosa preparations could be attributed to mitragynine, the main psychoactive compound isolated from its leaves. Therefore, comprehensive studies on the rewarding properties of mitragynine, as well as the mechanisms invoved, are needed. In the first part of the study, the rewarding properties of mitragynine (1, 5, 10 and 30 mg/kg) and its locomotor effects were investigated in Sprague-Dawley rats, using a conditioned place preference (CPP) paradigm. 2018-05 Thesis http://eprints.usm.my/44127/ http://eprints.usm.my/44127/1/NURUL%20HASNIDA%20MOHAMMAD%20YUSOFF.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Penyelidikan Dadah dan Ubat-ubatan |
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Universiti Sains Malaysia |
| collection |
USM Institutional Repository |
| language |
English |
| topic |
RS1-441 Pharmacy and materia medica |
| spellingShingle |
RS1-441 Pharmacy and materia medica Yusoff, Nurul Hasnida Mohammad Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats |
| description |
Mitragyna speciosa (M. speciosa) Korth is a traditional herbal plant indigenous to Southeast Asia. Regular use of this plant by human may lead to addiction with profound withdrawal symptoms. It is hypothesized that the abuse of M. speciosa preparations could be attributed to mitragynine, the main psychoactive compound isolated from its leaves. Therefore, comprehensive studies on the rewarding properties of mitragynine, as well as the mechanisms invoved, are needed. In the first part of the study, the rewarding properties of mitragynine (1, 5, 10 and 30 mg/kg) and its locomotor effects were investigated in Sprague-Dawley rats, using a conditioned place preference (CPP) paradigm. |
| format |
Thesis |
| qualification_name |
Doctor of Philosophy (PhD.) |
| qualification_level |
Doctorate |
| author |
Yusoff, Nurul Hasnida Mohammad |
| author_facet |
Yusoff, Nurul Hasnida Mohammad |
| author_sort |
Yusoff, Nurul Hasnida Mohammad |
| title |
Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats |
| title_short |
Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats |
| title_full |
Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats |
| title_fullStr |
Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats |
| title_full_unstemmed |
Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats |
| title_sort |
mitragynine-induced conditioned place preference (cpp) and the profiles of dopamine and its metabolites in rats |
| granting_institution |
Universiti Sains Malaysia |
| granting_department |
Pusat Penyelidikan Dadah dan Ubat-ubatan |
| publishDate |
2018 |
| url |
http://eprints.usm.my/44127/1/NURUL%20HASNIDA%20MOHAMMAD%20YUSOFF.pdf |
| _version_ |
1747821332891959296 |