Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate

The hypothetical de novo biosynthetic pathway of endosome-specific phospholipid, bis(monoacylglycero)phosphate (BMP) from endogenous phosphatidylglycerol (PG) precursor via lysophosphatidylglycerol (LPG) intermediate had been considered. In the present study, an alternative BMP biosynthetic route fr...

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Main Author:	Lim,, Shi Rou
Format:	Thesis
Language:	English
Published:	2018
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/44253/1/LIM%20SHI%20ROU.pdf
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id	my-usm-ep.44253
record_format	uketd_dc
spelling	my-usm-ep.442532019-05-06T00:55:09Z Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate 2018-03 Lim,, Shi Rou RS1-441 Pharmacy and materia medica The hypothetical de novo biosynthetic pathway of endosome-specific phospholipid, bis(monoacylglycero)phosphate (BMP) from endogenous phosphatidylglycerol (PG) precursor via lysophosphatidylglycerol (LPG) intermediate had been considered. In the present study, an alternative BMP biosynthetic route from PG via acylphosphatidylglycerol (AcPG) intermediate was proposed. A considerable amount of AcPG was found present in and outside the RAW 264.7 cells during 24 hours of incubation with exogenous PG. A transacylase is required to transfer an acyl chain from a PG donor to a PG acceptor, transforming the acceptor PG into AcPG and the donor PG into LPG. 2018-03 Thesis http://eprints.usm.my/44253/ http://eprints.usm.my/44253/1/LIM%20SHI%20ROU.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Lim,, Shi Rou Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate
description	The hypothetical de novo biosynthetic pathway of endosome-specific phospholipid, bis(monoacylglycero)phosphate (BMP) from endogenous phosphatidylglycerol (PG) precursor via lysophosphatidylglycerol (LPG) intermediate had been considered. In the present study, an alternative BMP biosynthetic route from PG via acylphosphatidylglycerol (AcPG) intermediate was proposed. A considerable amount of AcPG was found present in and outside the RAW 264.7 cells during 24 hours of incubation with exogenous PG. A transacylase is required to transfer an acyl chain from a PG donor to a PG acceptor, transforming the acceptor PG into AcPG and the donor PG into LPG.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Lim,, Shi Rou
author_facet	Lim,, Shi Rou
author_sort	Lim,, Shi Rou
title	Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate
title_short	Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate
title_full	Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate
title_fullStr	Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate
title_full_unstemmed	Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate
title_sort	biosynthesis of endosome-specific lipid bis(monoacylglycero)phosphate
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2018
url	http://eprints.usm.my/44253/1/LIM%20SHI%20ROU.pdf
_version_	1747821347999842304

Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate

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