Structure Based Design And Synthesis Of Potential Dengue Virus NS2B-NS3 Protease Inhibitors
Dengue is transmitted by the bite of a mosquito infected with one of the five dengue virus serotypes. As far as anti-dengue drug discovery is concerned, among few established therapeutic targets, NS2B-NS3 protease is quite popular due to its role in production of mature viruses and plays a key role...
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2018
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my-usm-ep.442732019-05-06T03:10:52Z Structure Based Design And Synthesis Of Potential Dengue Virus NS2B-NS3 Protease Inhibitors 2018-04 Sinha,, Suman RS1-441 Pharmacy and materia medica Dengue is transmitted by the bite of a mosquito infected with one of the five dengue virus serotypes. As far as anti-dengue drug discovery is concerned, among few established therapeutic targets, NS2B-NS3 protease is quite popular due to its role in production of mature viruses and plays a key role in maintaining infectivity. The work in this thesis described the computational and experimental studies in the design and synthesis of novel NS2B-NS3 protease from natural scaffolds such as lawsone and ferulic acid. In the case of naphthoquinone class of compounds, it was understood from docking studies that incorporation of molecular flexibility could lead to tighter binding compounds. 2018-04 Thesis http://eprints.usm.my/44273/ http://eprints.usm.my/44273/1/SUMAN%20SINHA.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi |
| institution |
Universiti Sains Malaysia |
| collection |
USM Institutional Repository |
| language |
English |
| topic |
RS1-441 Pharmacy and materia medica |
| spellingShingle |
RS1-441 Pharmacy and materia medica Sinha,, Suman Structure Based Design And Synthesis Of Potential Dengue Virus NS2B-NS3 Protease Inhibitors |
| description |
Dengue is transmitted by the bite of a mosquito infected with one of the five dengue virus serotypes. As far as anti-dengue drug discovery is concerned, among few established therapeutic targets, NS2B-NS3 protease is quite popular due to its role in production of mature viruses and plays a key role in maintaining infectivity. The work in this thesis described the computational and experimental studies in the design and synthesis of novel NS2B-NS3 protease from natural scaffolds such as lawsone and ferulic acid. In the case of naphthoquinone class of compounds, it was understood from docking studies that incorporation of molecular flexibility could lead to tighter binding compounds. |
| format |
Thesis |
| qualification_name |
Doctor of Philosophy (PhD.) |
| qualification_level |
Doctorate |
| author |
Sinha,, Suman |
| author_facet |
Sinha,, Suman |
| author_sort |
Sinha,, Suman |
| title |
Structure Based Design And Synthesis Of Potential Dengue Virus NS2B-NS3 Protease Inhibitors |
| title_short |
Structure Based Design And Synthesis Of Potential Dengue Virus NS2B-NS3 Protease Inhibitors |
| title_full |
Structure Based Design And Synthesis Of Potential Dengue Virus NS2B-NS3 Protease Inhibitors |
| title_fullStr |
Structure Based Design And Synthesis Of Potential Dengue Virus NS2B-NS3 Protease Inhibitors |
| title_full_unstemmed |
Structure Based Design And Synthesis Of Potential Dengue Virus NS2B-NS3 Protease Inhibitors |
| title_sort |
structure based design and synthesis of potential dengue virus ns2b-ns3 protease inhibitors |
| granting_institution |
Universiti Sains Malaysia |
| granting_department |
Pusat Pengajian Sains Farmasi |
| publishDate |
2018 |
| url |
http://eprints.usm.my/44273/1/SUMAN%20SINHA.pdf |
| _version_ |
1747821352144863232 |