The severity of preeclampsia and its associated factors in Hospital Universiti Sains Malaysia

Background: Preeclampsia (PE) is one of the leading cause of maternal mortality and morbidity worldwide. It occurs after 20 weeks of gestation with the presence of hypertension and proteinuria. The aim of this study was to determine the proportion and the associated factors of PE according to its...

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Main Author:	Mat Tamizi, Nurdiyana Farhana
Format:	Thesis
Language:	English
Published:	2017
Subjects:	RG Gynecology and obstetrics
Online Access:	http://eprints.usm.my/44464/1/Dr.%20Nurdiyana%20Farhana%20Mat%20Tarmiza-24%20pages.pdf
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spelling	my-usm-ep.444642020-10-22T03:03:10Z The severity of preeclampsia and its associated factors in Hospital Universiti Sains Malaysia 2017-07 Mat Tamizi, Nurdiyana Farhana RG Gynecology and obstetrics Background: Preeclampsia (PE) is one of the leading cause of maternal mortality and morbidity worldwide. It occurs after 20 weeks of gestation with the presence of hypertension and proteinuria. The aim of this study was to determine the proportion and the associated factors of PE according to its severity among patients in Hospital USM. Methods: A cross-sectional study involving 200 patients diagnosed with PE between years of 2011 to 2016 who were followed up and delivered in Hospital USM were included in this study. Patients from other referral hospitals in Kelantan and nearer states were also included to be the study samples. We also include those of chronic hypertension with superimposed PE, hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, and eclampsia. The severity classification of mild, moderate and severe PE was determined based on the National Institute of Health and Care Excellence (NICE) guideline. Ordinal logistic regression was used for analyzing. Results: The percentage of PE among patients in Hospital USM were found to be 34.7% in mild, 30.2% in moderate and 35.1% in severe cases. Higher uric acid resulted in greater odds of getting severe versus mild PE (Adjusted odds ratio (OR): 1.05, 95% CI: 1.02, 1.07) after adjusted for other variables. Patients having chronic hypertension (Adjusted OR: 2.36, 95% CI: 1.28, 4.33) and gestational diabetes mellitus (GDM) (Adjusted OR: 0.53, 95% CI: 0.30, 0.96) were also found to be associated with the severity of PE. Conclusion: Those who developedmild and severe PE was higher compared to moderate PE in this population. Patients with high uric acid and chronic hypertension have higher chances to get severe PE, while those with GDM was more likely to have mild PE. Uric acid, chronic hypertension, and GDM were significantly found to be associated with the severity of PE among patients in Hospital USM. A routine screening for PE based on BP and urine protein measurement should be practiced and done at every antenatal visit as recommended by World Health Organization (WHO). 2017-07 Thesis http://eprints.usm.my/44464/ http://eprints.usm.my/44464/1/Dr.%20Nurdiyana%20Farhana%20Mat%20Tarmiza-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RG Gynecology and obstetrics
spellingShingle	RG Gynecology and obstetrics Mat Tamizi, Nurdiyana Farhana The severity of preeclampsia and its associated factors in Hospital Universiti Sains Malaysia
description	Background: Preeclampsia (PE) is one of the leading cause of maternal mortality and morbidity worldwide. It occurs after 20 weeks of gestation with the presence of hypertension and proteinuria. The aim of this study was to determine the proportion and the associated factors of PE according to its severity among patients in Hospital USM. Methods: A cross-sectional study involving 200 patients diagnosed with PE between years of 2011 to 2016 who were followed up and delivered in Hospital USM were included in this study. Patients from other referral hospitals in Kelantan and nearer states were also included to be the study samples. We also include those of chronic hypertension with superimposed PE, hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, and eclampsia. The severity classification of mild, moderate and severe PE was determined based on the National Institute of Health and Care Excellence (NICE) guideline. Ordinal logistic regression was used for analyzing. Results: The percentage of PE among patients in Hospital USM were found to be 34.7% in mild, 30.2% in moderate and 35.1% in severe cases. Higher uric acid resulted in greater odds of getting severe versus mild PE (Adjusted odds ratio (OR): 1.05, 95% CI: 1.02, 1.07) after adjusted for other variables. Patients having chronic hypertension (Adjusted OR: 2.36, 95% CI: 1.28, 4.33) and gestational diabetes mellitus (GDM) (Adjusted OR: 0.53, 95% CI: 0.30, 0.96) were also found to be associated with the severity of PE. Conclusion: Those who developedmild and severe PE was higher compared to moderate PE in this population. Patients with high uric acid and chronic hypertension have higher chances to get severe PE, while those with GDM was more likely to have mild PE. Uric acid, chronic hypertension, and GDM were significantly found to be associated with the severity of PE among patients in Hospital USM. A routine screening for PE based on BP and urine protein measurement should be practiced and done at every antenatal visit as recommended by World Health Organization (WHO).
format	Thesis
qualification_level	Master's degree
author	Mat Tamizi, Nurdiyana Farhana
author_facet	Mat Tamizi, Nurdiyana Farhana
author_sort	Mat Tamizi, Nurdiyana Farhana
title	The severity of preeclampsia and its associated factors in Hospital Universiti Sains Malaysia
title_short	The severity of preeclampsia and its associated factors in Hospital Universiti Sains Malaysia
title_full	The severity of preeclampsia and its associated factors in Hospital Universiti Sains Malaysia
title_fullStr	The severity of preeclampsia and its associated factors in Hospital Universiti Sains Malaysia
title_full_unstemmed	The severity of preeclampsia and its associated factors in Hospital Universiti Sains Malaysia
title_sort	severity of preeclampsia and its associated factors in hospital universiti sains malaysia
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2017
url	http://eprints.usm.my/44464/1/Dr.%20Nurdiyana%20Farhana%20Mat%20Tarmiza-24%20pages.pdf
_version_	1747821375305809920

The severity of preeclampsia and its associated factors in Hospital Universiti Sains Malaysia

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