The effect of barley (hordeum vulgare L.) water extract a chemolytic agents in cholelithiasis (gallbladder stone) - an in-vitro study

Background: Cholelithiasis is a common disease since the early age of civilization, documented in history in ancient India and Egyptian few methods of treatment for the cholelithiasis, including detoxification of the body via gallbladder and liver by using specially prepared herbal oils. Fundamental...

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Main Author: Sulaiman, Ahmad Fardi Hj
Format: Thesis
Language:English
Published: 2017
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Online Access:http://eprints.usm.my/44522/1/Dr.%20Ahmad%20Fardi%20Sulaiman-24%20pages.pdf
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Summary:Background: Cholelithiasis is a common disease since the early age of civilization, documented in history in ancient India and Egyptian few methods of treatment for the cholelithiasis, including detoxification of the body via gallbladder and liver by using specially prepared herbal oils. Fundamentally, clinical and research practices would have analyzed the nature of the gallstone. Knowing the type of stone is a precondition in helping medical personnel to detect the risk factors of gallstone formation as well as to formulate the methods to minimize the occurrence. Even though they are well established treatment modalities in treating this disease, either by open or laparoscopic method of cholecystectomy, nevertheless chemolysis therapy of gallstone still practice in curtain part of the globe without any documented outcome. In this study, an in vitro experiment was conducted on extract of Hordeum Vulgare L. (Barley) to assess its effectiveness as a chemolytic agents in Cholelithiasis (Gallbladder Stone) under different concentration.Objectives: One of the objectives of this study is to determine the composition or types of gallbladder stones based on the test result and calculation by FTIR. On top of that, we also try to identify the optimum level of concentration of Hordeum Vulgare L. extract that has the best chemolytic effect on different types of gallbladder stone. Apart from that, the result of this study could also show us the stone type that has the maximum impact from Hordeum Vulgare L. extract. Our last objective is to distinguish the mostaffected chemical component of gallstone by the Hordeum Vulgare L. extract at the end of this test. Hopefully, after studying the result and outcomes of this research, new complimentary treatment strategies may be recommended and implemented to help patients with gallstones disease.