Ultrasound features in the diagnosis of biliary atresia
Objective: To assess the role of ultrasound (US) in the diagnosis of biliary atresia. Methodology: Fasting infants with conjugated hyperbilirubinemia were subjected for US examination in Hospital Sultanah Bahiyah, Kedah. The patients were grouped into biliary atresia (BA) and non-biliary atresia...
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my-usm-ep.446322020-10-22T03:03:14Z Ultrasound features in the diagnosis of biliary atresia 2017 Khim, Sim See R Medicine (General) Objective: To assess the role of ultrasound (US) in the diagnosis of biliary atresia. Methodology: Fasting infants with conjugated hyperbilirubinemia were subjected for US examination in Hospital Sultanah Bahiyah, Kedah. The patients were grouped into biliary atresia (BA) and non-biliary atresia (non-BA) based on the surgical findings and clinical follow up. The following features were recorded: tri-angular cord sign, gall bladder morphology, liver size, and echotexture, splenic size, hepatic artery size, hepatic artery to portal vein ratio, presence of a common bile duct, and presence of subcapsular flow on colour Doppler. Sensitivity, specificity, positive and negative predictive values were calculated for each US variable. BA and non-BA groups were compared by using the Fisher exact test for categorical variables and an unpaired t test for continues variable. Results: A total of 82 infants were included in the study; 42 had surgically confirmed BA and 40 had other documented causes of neonatal jaundice. Nine US features showed a significant different between BA and non-BA group. Ultrasound able to correctly classified 82 infants into BA and non-BA group with 98% accuracy. Conclusions: BA can be diagnosed with US from other cause of conjugated hyperbilirubinemia in 98% of patients if multiple US features are carefully evaluated. These ultrasound variables may serve as independent predictors of BA. 2017 Thesis http://eprints.usm.my/44632/ http://eprints.usm.my/44632/1/Dr.%20Sim%20See%20Khim-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan |
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Universiti Sains Malaysia |
| collection |
USM Institutional Repository |
| language |
English |
| topic |
R Medicine (General) |
| spellingShingle |
R Medicine (General) Khim, Sim See Ultrasound features in the diagnosis of biliary atresia |
| description |
Objective: To assess the role of ultrasound (US) in the diagnosis of biliary atresia.
Methodology: Fasting infants with conjugated hyperbilirubinemia were subjected for US
examination in Hospital Sultanah Bahiyah, Kedah. The patients were grouped into biliary atresia
(BA) and non-biliary atresia (non-BA) based on the surgical findings and clinical follow up. The
following features were recorded: tri-angular cord sign, gall bladder morphology, liver size, and
echotexture, splenic size, hepatic artery size, hepatic artery to portal vein ratio, presence of a
common bile duct, and presence of subcapsular flow on colour Doppler. Sensitivity, specificity,
positive and negative predictive values were calculated for each US variable. BA and non-BA
groups were compared by using the Fisher exact test for categorical variables and an unpaired t
test for continues variable.
Results: A total of 82 infants were included in the study; 42 had surgically confirmed BA and 40
had other documented causes of neonatal jaundice. Nine US features showed a significant different
between BA and non-BA group. Ultrasound able to correctly classified 82 infants into BA and
non-BA group with 98% accuracy.
Conclusions: BA can be diagnosed with US from other cause of conjugated hyperbilirubinemia
in 98% of patients if multiple US features are carefully evaluated. These ultrasound variables may
serve as independent predictors of BA. |
| format |
Thesis |
| qualification_level |
Master's degree |
| author |
Khim, Sim See |
| author_facet |
Khim, Sim See |
| author_sort |
Khim, Sim See |
| title |
Ultrasound features in the diagnosis of biliary atresia |
| title_short |
Ultrasound features in the diagnosis of biliary atresia |
| title_full |
Ultrasound features in the diagnosis of biliary atresia |
| title_fullStr |
Ultrasound features in the diagnosis of biliary atresia |
| title_full_unstemmed |
Ultrasound features in the diagnosis of biliary atresia |
| title_sort |
ultrasound features in the diagnosis of biliary atresia |
| granting_institution |
Universiti Sains Malaysia |
| granting_department |
Pusat Pengajian Sains Perubatan |
| publishDate |
2017 |
| url |
http://eprints.usm.my/44632/1/Dr.%20Sim%20See%20Khim-24%20pages.pdf |
| _version_ |
1747821388275646464 |