Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population

Loss of heterozygosity (LOH) and microsatellite instability (MSI) have been documented as important events of oral squamous cell carcinoma (OSCC). Five microsatellite markers D3S192, D3S966, D3S647, D3S1228 and D3S659 were selected on chromosome 3p because of high frequency of alterations reported i...

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Main Author:	Jusoh, Julia Ashaliza Mat
Format:	Thesis
Language:	English
Published:	2012
Subjects:	RK1-715 Dentistry
Online Access:	http://eprints.usm.my/44816/1/JULIA%20ASHAZILA%20BINTI%20MAT%20JUSOH.pdf
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id	my-usm-ep.44816
record_format	uketd_dc
spelling	my-usm-ep.448162019-07-02T07:11:02Z Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population 2012-05 Jusoh, Julia Ashaliza Mat RK1-715 Dentistry Loss of heterozygosity (LOH) and microsatellite instability (MSI) have been documented as important events of oral squamous cell carcinoma (OSCC). Five microsatellite markers D3S192, D3S966, D3S647, D3S1228 and D3S659 were selected on chromosome 3p because of high frequency of alterations reported in head and neck squamous cell carcinoma and the involvement of VHL (von Hippel Lindau) at 3p25-26 and the FHIT (fragile histidine triad) at 3p14.2 genes proven in many tumor types. A total of 50 archival tissue samples of OSCC and corresponding normal samples were analyzed for LOH and MSI status. The overall LOH for the markers selected on 3p was 56 out of 189 informative cases (29.6%). 2012-05 Thesis http://eprints.usm.my/44816/ http://eprints.usm.my/44816/1/JULIA%20ASHAZILA%20BINTI%20MAT%20JUSOH.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Pergigian
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RK1-715 Dentistry
spellingShingle	RK1-715 Dentistry Jusoh, Julia Ashaliza Mat Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population
description	Loss of heterozygosity (LOH) and microsatellite instability (MSI) have been documented as important events of oral squamous cell carcinoma (OSCC). Five microsatellite markers D3S192, D3S966, D3S647, D3S1228 and D3S659 were selected on chromosome 3p because of high frequency of alterations reported in head and neck squamous cell carcinoma and the involvement of VHL (von Hippel Lindau) at 3p25-26 and the FHIT (fragile histidine triad) at 3p14.2 genes proven in many tumor types. A total of 50 archival tissue samples of OSCC and corresponding normal samples were analyzed for LOH and MSI status. The overall LOH for the markers selected on 3p was 56 out of 189 informative cases (29.6%).
format	Thesis
qualification_level	Master's degree
author	Jusoh, Julia Ashaliza Mat
author_facet	Jusoh, Julia Ashaliza Mat
author_sort	Jusoh, Julia Ashaliza Mat
title	Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population
title_short	Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population
title_full	Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population
title_fullStr	Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population
title_full_unstemmed	Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population
title_sort	microsatellite instability and loss of heterozygosity in oral squamous cell carcinoma in a malaysian population
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Pergigian
publishDate	2012
url	http://eprints.usm.my/44816/1/JULIA%20ASHAZILA%20BINTI%20MAT%20JUSOH.pdf
_version_	1747821404878798848

Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population

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