Genetic Polymorphisms Of Inflammation Response Genes And Their Influence On Malaysian Colorectal Cancer Patients : A Case Control Study
Sporadic colorectal cancer (CRC) is a complex and multi-factorial disease caused by the interaction of environmental and genetic predisposition factors. However the genetic susceptibility or predisposition risk of a certain individual to development of sporadic CRC remains largely undetermined. Rece...
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| Format: | Thesis |
| Language: | English |
| Published: |
2012
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| Subjects: | |
| Online Access: | http://eprints.usm.my/44844/1/MOHD%20AMINUDIN%20BIN%20MUSTAPHA.pdf |
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| Summary: | Sporadic colorectal cancer (CRC) is a complex and multi-factorial disease caused by the interaction of environmental and genetic predisposition factors. However the genetic susceptibility or predisposition risk of a certain individual to development of sporadic CRC remains largely undetermined. Recently chronic inflammation has been documented as a predisposing factor for CRC development. It was hypothesized that a pro-inflammatory genetic profile represented by genetic variation in inflammation response genes might be associated with increased susceptibility to CRC and a study was designed to test the hypothesis. |
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