Screening For Small Molecule Inhibitors Of p27Kip1 Degradation
In a majority of human cancers, the cyclin-dependent kinase (CDK) inhibitor p27Kip1 is commonly found to be deregulated due to proteolysis by the ubiquitin-proteasome pathway involving the SCFSkp2 E3 ligase. Although proteasome inhibitors act to stabilize p27Kip1, small molecules agents inhibiting t...
محفوظ في:
المؤلف الرئيسي: | Ooi, Li Ching |
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التنسيق: | أطروحة |
اللغة: | English |
منشور في: |
2012
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الموضوعات: | |
الوصول للمادة أونلاين: | http://eprints.usm.my/44880/1/OOI%20LI%20CHING.pdf |
الوسوم: |
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