Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates

Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates

Bioconjugates (PNIPAAm−graft−DNA) of poly(N-isopropylacrylamide) (PNIPAAm) grafted with single-stranded (ss) DNA were synthesized via radical copolymerization. The bioconjugates self-assembled above its lower critical solution temperature (LCST) in aqueous solution to form micelle-like colloidal nan...

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Main Author: Ooi, Wei Yang
Format: Thesis
Language:English
Published: 2012
Subjects:
QH1 Natural history (General - Including nature conservation
geographical distribution)
Online Access:http://eprints.usm.my/44882/1/OOI%20WEI%20YANG.pdf
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spelling my-usm-ep.448822019-07-05T02:18:22Z Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates 2012-07 Ooi, Wei Yang QH1 Natural history (General - Including nature conservation, geographical distribution) Bioconjugates (PNIPAAm−graft−DNA) of poly(N-isopropylacrylamide) (PNIPAAm) grafted with single-stranded (ss) DNA were synthesized via radical copolymerization. The bioconjugates self-assembled above its lower critical solution temperature (LCST) in aqueous solution to form micelle-like colloidal nanoparticles. When the ssDNA of the nanoparticle hybridizes with complementary DNA, the particles aggregate above a certain threshold of salt concentration with drastically increased turbidity in solution. 2012-07 Thesis http://eprints.usm.my/44882/ http://eprints.usm.my/44882/1/OOI%20WEI%20YANG.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Kajihayat
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic QH1 Natural history (General - Including nature conservation
geographical distribution)
spellingShingle QH1 Natural history (General - Including nature conservation
geographical distribution)
Ooi, Wei Yang
Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates
description Bioconjugates (PNIPAAm−graft−DNA) of poly(N-isopropylacrylamide) (PNIPAAm) grafted with single-stranded (ss) DNA were synthesized via radical copolymerization. The bioconjugates self-assembled above its lower critical solution temperature (LCST) in aqueous solution to form micelle-like colloidal nanoparticles. When the ssDNA of the nanoparticle hybridizes with complementary DNA, the particles aggregate above a certain threshold of salt concentration with drastically increased turbidity in solution.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Ooi, Wei Yang
author_facet Ooi, Wei Yang
author_sort Ooi, Wei Yang
title Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates
title_short Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates
title_full Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates
title_fullStr Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates
title_full_unstemmed Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates
title_sort synthesis and characterization of thermoresponsive poly(n-isoproylacrylamide)-dna bioconjugates
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Kajihayat
publishDate 2012
url http://eprints.usm.my/44882/1/OOI%20WEI%20YANG.pdf
_version_ 1747821418739924992

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