A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia
Retinoblastoma (RB) is the most common primary intraocular tumor affecting mainly children under five years of age, with a prevalence of 1 in 15 000 to 20 000 live births. Retinoblastoma is divided into hereditary and sporadic types. It is caused by mutations or changes in RB1 gene, a tumor suppress...
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my-usm-ep.449062019-07-09T01:17:17Z A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia 2012-05 Hashim, Siti Norulhuda Haji Draman @ R5-920 Medicine (General) Retinoblastoma (RB) is the most common primary intraocular tumor affecting mainly children under five years of age, with a prevalence of 1 in 15 000 to 20 000 live births. Retinoblastoma is divided into hereditary and sporadic types. It is caused by mutations or changes in RB1 gene, a tumor suppressor gene. The aim of this study is to detect mutations in N-terminus, C-terminus and promoter region of RB1 gene in retinoblastoma patients in Malaysia, as well as its association with staging and laterality of the patients. A total of 68 children with sporadic RB from Hospital Universiti Sains Malaysia (HUSM), Hospital Kuala Lumpur (HKL) and University Malaya Medical Centre (UMMC) and 68 healthy ethnic-matched controls were recruited. 2012-05 Thesis http://eprints.usm.my/44906/ http://eprints.usm.my/44906/1/SITI%20NORULHUDA%20BT%20HAJI%20DRAMAN%20%40%20HASHIM.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan |
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R5-920 Medicine (General) Hashim, Siti Norulhuda Haji Draman @ A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia |
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Retinoblastoma (RB) is the most common primary intraocular tumor affecting mainly children under five years of age, with a prevalence of 1 in 15 000 to 20 000 live births. Retinoblastoma is divided into hereditary and sporadic types. It is caused by mutations or changes in RB1 gene, a tumor suppressor gene. The aim of this study is to detect mutations in N-terminus, C-terminus and promoter region of RB1 gene in retinoblastoma patients in Malaysia, as well as its association with staging and laterality of the patients. A total of 68 children with sporadic RB from Hospital Universiti Sains Malaysia (HUSM), Hospital Kuala Lumpur (HKL) and University Malaya Medical Centre (UMMC) and 68 healthy ethnic-matched controls were recruited. |
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Master's degree |
author |
Hashim, Siti Norulhuda Haji Draman @ |
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Hashim, Siti Norulhuda Haji Draman @ |
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Hashim, Siti Norulhuda Haji Draman @ |
title |
A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia |
title_short |
A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia |
title_full |
A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia |
title_fullStr |
A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia |
title_full_unstemmed |
A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia |
title_sort |
study of the genetic variations in n-terminus, c-terminus and promoter of rb1 gene among retinoblastoma patients in malaysia |
granting_institution |
Universiti Sains Malaysia |
granting_department |
Pusat Pengajian Sains Perubatan |
publishDate |
2012 |
url |
http://eprints.usm.my/44906/1/SITI%20NORULHUDA%20BT%20HAJI%20DRAMAN%20%40%20HASHIM.pdf |
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1747821422652162048 |