Diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients
Objective: The purpose of this study is to determine whether interictal DTI and apparent diffusion coefficients (ADC) provide a robust means for detecting hippocampal formation abnormalities in patients with medically intractable temporal lobe epilepsy (TLE). Methodology: Fourteen patients and 1...
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my-usm-ep.449652020-10-22T03:03:14Z Diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients 2017 Jalil, Farouk RC31-1245 Internal medicine Objective: The purpose of this study is to determine whether interictal DTI and apparent diffusion coefficients (ADC) provide a robust means for detecting hippocampal formation abnormalities in patients with medically intractable temporal lobe epilepsy (TLE). Methodology: Fourteen patients and 14 controls were studied with hippocampal formation ADC maps, fractional anisotropy and Trace D values. MR images were evaluated for loss of volume and/or high signal intensity on T2-weighted images and compared with DTI and ADC maps. Mean and SDs were obtained for each measurement, and level of significance was determined (P < .05). The relationship between EEG lateralization and MR imaging and DTI/ADCs were studied. Results : Ten patients had right-sided lateralization and 4 had left-sided lateralization on EEG. Patients demonstrated higher ADC within the diseased hippocampus (0.54 x 10-3 s/mm2) in comparison with the contralateral side and that of controls (0.39 x10- 3s/mm2 and 0.40 x 10-3s/mm2, respectively) (P < .05). Positive correlations were seen between hippocampal apparent diffusion coefficients and fractional anisotropy (P < .05). Conclusion : ADC and DTI have the capabilities to detect changes in the hippocampal formation and to lateralize the seizure focus in patients with TLE despite absence of morphological changes on conventional MRI sequence. 2017 Thesis http://eprints.usm.my/44965/ http://eprints.usm.my/44965/1/Dr.%20Farouk%20Hj%20Jalil-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan |
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Universiti Sains Malaysia |
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USM Institutional Repository |
language |
English |
topic |
RC31-1245 Internal medicine |
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RC31-1245 Internal medicine Jalil, Farouk Diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients |
description |
Objective: The purpose of this study is to determine whether interictal DTI and
apparent diffusion coefficients (ADC) provide a robust means for detecting
hippocampal formation abnormalities in patients with medically intractable temporal
lobe epilepsy (TLE).
Methodology: Fourteen patients and 14 controls were studied with hippocampal
formation ADC maps, fractional anisotropy and Trace D values. MR images were
evaluated for loss of volume and/or high signal intensity on T2-weighted images and
compared with DTI and ADC maps. Mean and SDs were obtained for each
measurement, and level of significance was determined (P < .05). The relationship
between EEG lateralization and MR imaging and DTI/ADCs were studied.
Results : Ten patients had right-sided lateralization and 4 had left-sided lateralization
on EEG. Patients demonstrated higher ADC within the diseased hippocampus (0.54 x
10-3 s/mm2) in comparison with the contralateral side and that of controls (0.39 x10-
3s/mm2 and 0.40 x 10-3s/mm2, respectively) (P < .05). Positive correlations were seen
between hippocampal apparent diffusion coefficients and fractional anisotropy (P
< .05).
Conclusion : ADC and DTI have the capabilities to detect changes in the hippocampal
formation and to lateralize the seizure focus in patients with TLE despite absence of
morphological changes on conventional MRI sequence. |
format |
Thesis |
qualification_level |
Master's degree |
author |
Jalil, Farouk |
author_facet |
Jalil, Farouk |
author_sort |
Jalil, Farouk |
title |
Diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients |
title_short |
Diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients |
title_full |
Diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients |
title_fullStr |
Diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients |
title_full_unstemmed |
Diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients |
title_sort |
diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients |
granting_institution |
Universiti Sains Malaysia |
granting_department |
Pusat Pengajian Sains Perubatan |
publishDate |
2017 |
url |
http://eprints.usm.my/44965/1/Dr.%20Farouk%20Hj%20Jalil-24%20pages.pdf |
_version_ |
1747821430440984576 |