Diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients

Objective: The purpose of this study is to determine whether interictal DTI and apparent diffusion coefficients (ADC) provide a robust means for detecting hippocampal formation abnormalities in patients with medically intractable temporal lobe epilepsy (TLE). Methodology: Fourteen patients and 1...

Full description

Saved in:

Bibliographic Details
Main Author:	Jalil, Farouk
Format:	Thesis
Language:	English
Published:	2017
Subjects:	RC31-1245 Internal medicine
Online Access:	http://eprints.usm.my/44965/1/Dr.%20Farouk%20Hj%20Jalil-24%20pages.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.44965
record_format	uketd_dc
spelling	my-usm-ep.449652020-10-22T03:03:14Z Diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients 2017 Jalil, Farouk RC31-1245 Internal medicine Objective: The purpose of this study is to determine whether interictal DTI and apparent diffusion coefficients (ADC) provide a robust means for detecting hippocampal formation abnormalities in patients with medically intractable temporal lobe epilepsy (TLE). Methodology: Fourteen patients and 14 controls were studied with hippocampal formation ADC maps, fractional anisotropy and Trace D values. MR images were evaluated for loss of volume and/or high signal intensity on T2-weighted images and compared with DTI and ADC maps. Mean and SDs were obtained for each measurement, and level of significance was determined (P < .05). The relationship between EEG lateralization and MR imaging and DTI/ADCs were studied. Results : Ten patients had right-sided lateralization and 4 had left-sided lateralization on EEG. Patients demonstrated higher ADC within the diseased hippocampus (0.54 x 10-3 s/mm2) in comparison with the contralateral side and that of controls (0.39 x10- 3s/mm2 and 0.40 x 10-3s/mm2, respectively) (P < .05). Positive correlations were seen between hippocampal apparent diffusion coefficients and fractional anisotropy (P < .05). Conclusion : ADC and DTI have the capabilities to detect changes in the hippocampal formation and to lateralize the seizure focus in patients with TLE despite absence of morphological changes on conventional MRI sequence. 2017 Thesis http://eprints.usm.my/44965/ http://eprints.usm.my/44965/1/Dr.%20Farouk%20Hj%20Jalil-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC31-1245 Internal medicine
spellingShingle	RC31-1245 Internal medicine Jalil, Farouk Diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients
description	Objective: The purpose of this study is to determine whether interictal DTI and apparent diffusion coefficients (ADC) provide a robust means for detecting hippocampal formation abnormalities in patients with medically intractable temporal lobe epilepsy (TLE). Methodology: Fourteen patients and 14 controls were studied with hippocampal formation ADC maps, fractional anisotropy and Trace D values. MR images were evaluated for loss of volume and/or high signal intensity on T2-weighted images and compared with DTI and ADC maps. Mean and SDs were obtained for each measurement, and level of significance was determined (P < .05). The relationship between EEG lateralization and MR imaging and DTI/ADCs were studied. Results : Ten patients had right-sided lateralization and 4 had left-sided lateralization on EEG. Patients demonstrated higher ADC within the diseased hippocampus (0.54 x 10-3 s/mm2) in comparison with the contralateral side and that of controls (0.39 x10- 3s/mm2 and 0.40 x 10-3s/mm2, respectively) (P < .05). Positive correlations were seen between hippocampal apparent diffusion coefficients and fractional anisotropy (P < .05). Conclusion : ADC and DTI have the capabilities to detect changes in the hippocampal formation and to lateralize the seizure focus in patients with TLE despite absence of morphological changes on conventional MRI sequence.
format	Thesis
qualification_level	Master's degree
author	Jalil, Farouk
author_facet	Jalil, Farouk
author_sort	Jalil, Farouk
title	Diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients
title_short	Diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients
title_full	Diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients
title_fullStr	Diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients
title_full_unstemmed	Diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients
title_sort	diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2017
url	http://eprints.usm.my/44965/1/Dr.%20Farouk%20Hj%20Jalil-24%20pages.pdf
_version_	1747821430440984576

Diffusion tensor imaging and apparent diffusion coefficient values of hippocampal formation in medically intractable temporal lobe epilepsy patients

Similar Items