Detailed anatomical volumetric study of deep nuclei of brain and other structures between parkinson's disease patients who had deep brain stimulation (DBS) and control group

Background: In my country, Deep Brain stimulation surgery (DBS) was pioneered by Neuroscience team Hospital Universiti Sains Malaysia (HUSM) nearly a decade ago. The treatment was mainly directed to advanced Idiopathic Parkinson’s Disease (PD) patients. Objectives: It is known that volume reducti...

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Main Author:	Hwee, Goh Chin
Format:	Thesis
Language:	English
Published:	2017
Subjects:	RC31-1245 Internal medicine
Online Access:	http://eprints.usm.my/44979/1/Dr.%20Goh%20Chin%20Hwee-24%20pages.pdf
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spelling	my-usm-ep.449792020-10-22T03:03:14Z Detailed anatomical volumetric study of deep nuclei of brain and other structures between parkinson's disease patients who had deep brain stimulation (DBS) and control group 2017 Hwee, Goh Chin RC31-1245 Internal medicine Background: In my country, Deep Brain stimulation surgery (DBS) was pioneered by Neuroscience team Hospital Universiti Sains Malaysia (HUSM) nearly a decade ago. The treatment was mainly directed to advanced Idiopathic Parkinson’s Disease (PD) patients. Objectives: It is known that volume reduction occurs with age, we searched to define the degree of volume discrepancy in PD patients and attempted to correlate the anatomical volumetric changes to motor symptoms and cognitive function. Methods: The research aimed to establish a baseline Magnetic resonance imaging (MRI) based volumetric analysis of the seven brain structures (Head of caudate nucleus, Putamen, Thalamus, Globus pallidus, Hippocampal head, Amygdala & Subthalamic nucleus) of selected pre-DBS advanced PD patients in comparison to matched healthy controls. Results: Significant atrophy and volume discrepancy were observed in PD surgical group, though thalamus and amygdala were not affected. Positive correlation of globus pallidus volume to higher mental function in the absence of cognitive or behavioural problem. Conclusions: These findings might imply that structural alteration could be the early changes prior to clinical manifestation and PD involves multiple alternative pathway other than nigrostriatal circuit. 2017 Thesis http://eprints.usm.my/44979/ http://eprints.usm.my/44979/1/Dr.%20Goh%20Chin%20Hwee-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC31-1245 Internal medicine
spellingShingle	RC31-1245 Internal medicine Hwee, Goh Chin Detailed anatomical volumetric study of deep nuclei of brain and other structures between parkinson's disease patients who had deep brain stimulation (DBS) and control group
description	Background: In my country, Deep Brain stimulation surgery (DBS) was pioneered by Neuroscience team Hospital Universiti Sains Malaysia (HUSM) nearly a decade ago. The treatment was mainly directed to advanced Idiopathic Parkinson’s Disease (PD) patients. Objectives: It is known that volume reduction occurs with age, we searched to define the degree of volume discrepancy in PD patients and attempted to correlate the anatomical volumetric changes to motor symptoms and cognitive function. Methods: The research aimed to establish a baseline Magnetic resonance imaging (MRI) based volumetric analysis of the seven brain structures (Head of caudate nucleus, Putamen, Thalamus, Globus pallidus, Hippocampal head, Amygdala & Subthalamic nucleus) of selected pre-DBS advanced PD patients in comparison to matched healthy controls. Results: Significant atrophy and volume discrepancy were observed in PD surgical group, though thalamus and amygdala were not affected. Positive correlation of globus pallidus volume to higher mental function in the absence of cognitive or behavioural problem. Conclusions: These findings might imply that structural alteration could be the early changes prior to clinical manifestation and PD involves multiple alternative pathway other than nigrostriatal circuit.
format	Thesis
qualification_level	Master's degree
author	Hwee, Goh Chin
author_facet	Hwee, Goh Chin
author_sort	Hwee, Goh Chin
title	Detailed anatomical volumetric study of deep nuclei of brain and other structures between parkinson's disease patients who had deep brain stimulation (DBS) and control group
title_short	Detailed anatomical volumetric study of deep nuclei of brain and other structures between parkinson's disease patients who had deep brain stimulation (DBS) and control group
title_full	Detailed anatomical volumetric study of deep nuclei of brain and other structures between parkinson's disease patients who had deep brain stimulation (DBS) and control group
title_fullStr	Detailed anatomical volumetric study of deep nuclei of brain and other structures between parkinson's disease patients who had deep brain stimulation (DBS) and control group
title_full_unstemmed	Detailed anatomical volumetric study of deep nuclei of brain and other structures between parkinson's disease patients who had deep brain stimulation (DBS) and control group
title_sort	detailed anatomical volumetric study of deep nuclei of brain and other structures between parkinson's disease patients who had deep brain stimulation (dbs) and control group
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2017
url	http://eprints.usm.my/44979/1/Dr.%20Goh%20Chin%20Hwee-24%20pages.pdf
_version_	1747821431911088128

Detailed anatomical volumetric study of deep nuclei of brain and other structures between parkinson's disease patients who had deep brain stimulation (DBS) and control group

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