The Effects Of Aerosol-Based Cell Delivery Technique On The Regeneration And Repair Of Airway Epithelium

Aerosol-based cell delivery is a potential therapeutic strategy to overcome the debilitating reparative capacity of trachea and lung following injury. The goal of this study was to determine the effect of aerosol-based airway epithelial cell (AEC) delivery on tracheal repair and regeneration, lung d...

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Main Author:	., Egi Kardia
Format:	Thesis
Language:	English
Published:	2017
Subjects:	R735-854 Medical education Medical schools Research
Online Access:	http://eprints.usm.my/44995/1/EGI%20KARDIA.pdf
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id	my-usm-ep.44995
record_format	uketd_dc
spelling	my-usm-ep.449952019-07-22T06:37:09Z The Effects Of Aerosol-Based Cell Delivery Technique On The Regeneration And Repair Of Airway Epithelium 2017-08 ., Egi Kardia R735-854 Medical education. Medical schools. Research Aerosol-based cell delivery is a potential therapeutic strategy to overcome the debilitating reparative capacity of trachea and lung following injury. The goal of this study was to determine the effect of aerosol-based airway epithelial cell (AEC) delivery on tracheal repair and regeneration, lung damage, and local inflammatory responses in the setting of acute lung injury (ALI) induced by tracheal brushing in rabbit. AECs were isolated from the trachea of New Zealand white rabbits. In vitro aerosol delivery was performed to assess the viability of the cells. Brushing-induced tracheal injury was performed in a rabbit model to develop ALI. One day following injury, exogenous BrdU-labelled AECs were aerosolized using the MicroSprayer® Aerosolizer into the injured airway. 2017-08 Thesis http://eprints.usm.my/44995/ http://eprints.usm.my/44995/1/EGI%20KARDIA.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R735-854 Medical education Medical schools Research
spellingShingle	R735-854 Medical education Medical schools Research ., Egi Kardia The Effects Of Aerosol-Based Cell Delivery Technique On The Regeneration And Repair Of Airway Epithelium
description	Aerosol-based cell delivery is a potential therapeutic strategy to overcome the debilitating reparative capacity of trachea and lung following injury. The goal of this study was to determine the effect of aerosol-based airway epithelial cell (AEC) delivery on tracheal repair and regeneration, lung damage, and local inflammatory responses in the setting of acute lung injury (ALI) induced by tracheal brushing in rabbit. AECs were isolated from the trachea of New Zealand white rabbits. In vitro aerosol delivery was performed to assess the viability of the cells. Brushing-induced tracheal injury was performed in a rabbit model to develop ALI. One day following injury, exogenous BrdU-labelled AECs were aerosolized using the MicroSprayer® Aerosolizer into the injured airway.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	., Egi Kardia
author_facet	., Egi Kardia
author_sort	., Egi Kardia
title	The Effects Of Aerosol-Based Cell Delivery Technique On The Regeneration And Repair Of Airway Epithelium
title_short	The Effects Of Aerosol-Based Cell Delivery Technique On The Regeneration And Repair Of Airway Epithelium
title_full	The Effects Of Aerosol-Based Cell Delivery Technique On The Regeneration And Repair Of Airway Epithelium
title_fullStr	The Effects Of Aerosol-Based Cell Delivery Technique On The Regeneration And Repair Of Airway Epithelium
title_full_unstemmed	The Effects Of Aerosol-Based Cell Delivery Technique On The Regeneration And Repair Of Airway Epithelium
title_sort	effects of aerosol-based cell delivery technique on the regeneration and repair of airway epithelium
granting_institution	Universiti Sains Malaysia
granting_department	Institut Perubatan & Pergigian Termaju
publishDate	2017
url	http://eprints.usm.my/44995/1/EGI%20KARDIA.pdf
_version_	1747821434586005504

The Effects Of Aerosol-Based Cell Delivery Technique On The Regeneration And Repair Of Airway Epithelium

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