Identification Of Antigens Recognized By The Monoclonal Antibody, IBMR3 On Lymphocytes And Established Cell Lines

Monoclonal antibodies have demonstrated significant utilities in both research and clinical applications. IBMR3 monoclonal antibody (IBMR3 MAb) has been shown to recognize a molecule that may be associated with the human interleukin-4 receptor (IL-4R) complex. IL-4 has been shown to be extensively a...

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Main Author:	Aris, Farizan
Format:	Thesis
Language:	English
Published:	2016
Subjects:	R735-854 Medical education Medical schools Research
Online Access:	http://eprints.usm.my/45000/1/FARIZAN%20ARIS.pdf
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id	my-usm-ep.45000
record_format	uketd_dc
spelling	my-usm-ep.450002019-07-22T07:34:48Z Identification Of Antigens Recognized By The Monoclonal Antibody, IBMR3 On Lymphocytes And Established Cell Lines 2016-09 Aris, Farizan R735-854 Medical education. Medical schools. Research Monoclonal antibodies have demonstrated significant utilities in both research and clinical applications. IBMR3 monoclonal antibody (IBMR3 MAb) has been shown to recognize a molecule that may be associated with the human interleukin-4 receptor (IL-4R) complex. IL-4 has been shown to be extensively associated with cancer. The aim of this study is to identify the IBMR3 antigen (IBMR3 Ag) expressed in normal peripheral blood mononuclear cells (PBMC) and in a panel of established cell lines. Immunostaining revealed that IBMR3 MAb can recognize antigen in a variety of cell types, including epithelial, fibroblast, haemopoietic, cancer, and normal cells. Interestingly, IBMR3 Ag was found to be expressed in the cytoplasm but was absent on the cell surface except for normal lymphocytes. 2016-09 Thesis http://eprints.usm.my/45000/ http://eprints.usm.my/45000/1/FARIZAN%20ARIS.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R735-854 Medical education Medical schools Research
spellingShingle	R735-854 Medical education Medical schools Research Aris, Farizan Identification Of Antigens Recognized By The Monoclonal Antibody, IBMR3 On Lymphocytes And Established Cell Lines
description	Monoclonal antibodies have demonstrated significant utilities in both research and clinical applications. IBMR3 monoclonal antibody (IBMR3 MAb) has been shown to recognize a molecule that may be associated with the human interleukin-4 receptor (IL-4R) complex. IL-4 has been shown to be extensively associated with cancer. The aim of this study is to identify the IBMR3 antigen (IBMR3 Ag) expressed in normal peripheral blood mononuclear cells (PBMC) and in a panel of established cell lines. Immunostaining revealed that IBMR3 MAb can recognize antigen in a variety of cell types, including epithelial, fibroblast, haemopoietic, cancer, and normal cells. Interestingly, IBMR3 Ag was found to be expressed in the cytoplasm but was absent on the cell surface except for normal lymphocytes.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Aris, Farizan
author_facet	Aris, Farizan
author_sort	Aris, Farizan
title	Identification Of Antigens Recognized By The Monoclonal Antibody, IBMR3 On Lymphocytes And Established Cell Lines
title_short	Identification Of Antigens Recognized By The Monoclonal Antibody, IBMR3 On Lymphocytes And Established Cell Lines
title_full	Identification Of Antigens Recognized By The Monoclonal Antibody, IBMR3 On Lymphocytes And Established Cell Lines
title_fullStr	Identification Of Antigens Recognized By The Monoclonal Antibody, IBMR3 On Lymphocytes And Established Cell Lines
title_full_unstemmed	Identification Of Antigens Recognized By The Monoclonal Antibody, IBMR3 On Lymphocytes And Established Cell Lines
title_sort	identification of antigens recognized by the monoclonal antibody, ibmr3 on lymphocytes and established cell lines
granting_institution	Universiti Sains Malaysia
granting_department	Institut Perubatan & Pergigian Termaju
publishDate	2016
url	http://eprints.usm.my/45000/1/FARIZAN%20ARIS.pdf
_version_	1747821435563278336

Identification Of Antigens Recognized By The Monoclonal Antibody, IBMR3 On Lymphocytes And Established Cell Lines

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