Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro

Background: Bone marrow-derived mesenchymal stem cells (MSCs) has been shown to facilitate heart repair via activation of endogenous cardiac stem cells (CSCs) following infarction, but little is known if the synergy of the two cells can be exploited in vitro prior to transplantation. Objective: This...

Full description

Saved in:

Bibliographic Details
Main Author:	Leong, Yin Yee
Format:	Thesis
Language:	English
Published:	2016
Subjects:	R735-854 Medical education Medical schools Research
Online Access:	http://eprints.usm.my/45006/1/LEONG%20YIN%20YEE.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.45006
record_format	uketd_dc
spelling	my-usm-ep.450062019-07-23T00:56:18Z Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro 2016-01 Leong, Yin Yee R735-854 Medical education. Medical schools. Research Background: Bone marrow-derived mesenchymal stem cells (MSCs) has been shown to facilitate heart repair via activation of endogenous cardiac stem cells (CSCs) following infarction, but little is known if the synergy of the two cells can be exploited in vitro prior to transplantation. Objective: This study aimed to examine the synergistic effects of MSCs on CSC cardiomyocyte differentiation. Methods: C-kit CSCs and MSCs were isolated from 4-6 weeks C57BL/6N mice (n=9). CSC cardiomyocyte differentiation was tested after re-isolated from MSC co-culture using micron-sized particles of iron oxide, and compared to CSCs treated with MSC-conditioned medium (CdM) or without any treatment. 2016-01 Thesis http://eprints.usm.my/45006/ http://eprints.usm.my/45006/1/LEONG%20YIN%20YEE.pdf application/pdf en public masters Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R735-854 Medical education Medical schools Research
spellingShingle	R735-854 Medical education Medical schools Research Leong, Yin Yee Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro
description	Background: Bone marrow-derived mesenchymal stem cells (MSCs) has been shown to facilitate heart repair via activation of endogenous cardiac stem cells (CSCs) following infarction, but little is known if the synergy of the two cells can be exploited in vitro prior to transplantation. Objective: This study aimed to examine the synergistic effects of MSCs on CSC cardiomyocyte differentiation. Methods: C-kit CSCs and MSCs were isolated from 4-6 weeks C57BL/6N mice (n=9). CSC cardiomyocyte differentiation was tested after re-isolated from MSC co-culture using micron-sized particles of iron oxide, and compared to CSCs treated with MSC-conditioned medium (CdM) or without any treatment.
format	Thesis
qualification_level	Master's degree
author	Leong, Yin Yee
author_facet	Leong, Yin Yee
author_sort	Leong, Yin Yee
title	Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro
title_short	Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro
title_full	Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro
title_fullStr	Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro
title_full_unstemmed	Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro
title_sort	interaction between murine cardiac stem cells and bone marrow-derived mesenchymal stem cells for cardiomyocyte differentiation in vitro
granting_institution	Universiti Sains Malaysia
granting_department	Institut Perubatan & Pergigian Termaju
publishDate	2016
url	http://eprints.usm.my/45006/1/LEONG%20YIN%20YEE.pdf
_version_	1747821436536356864

Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro

Similar Items