The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells

The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells

Cancer stem cells (CSCs) represent a small subpopulation within a tumour that possesses the stem-like properties but are also initiating resistance towards cytotoxic agent which contribute to cancer relapse. A natural compound such as curcumin that contains high polyphenol has been found to possess...

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Main Author: Nazilah, Abdul Satar
Format: Thesis
Language:English
Published: 2018
Subjects:
R735-854 Medical education
Medical schools
Research
Online Access:http://eprints.usm.my/45013/1/NAZILAH%20ABDUL%20SATAR.pdf
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spelling my-usm-ep.450132019-07-23T01:40:22Z The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells 2018-09 Nazilah, Abdul Satar R735-854 Medical education. Medical schools. Research Cancer stem cells (CSCs) represent a small subpopulation within a tumour that possesses the stem-like properties but are also initiating resistance towards cytotoxic agent which contribute to cancer relapse. A natural compound such as curcumin that contains high polyphenol has been found to possess chemo-sensitivity effect with an ability to sensitise the CSCs to the cytotoxic agents such as cisplatin. Therefore, the present study was designed to investigate the efficiency of curcumin as a chemo-sensitiser in lung CSCs and to analyse its inhibitory effect on CSCs activity using A549 and H2170 cell lines that belong to non-small cell lung cancer (NSCLC). 2018-09 Thesis http://eprints.usm.my/45013/ http://eprints.usm.my/45013/1/NAZILAH%20ABDUL%20SATAR.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic R735-854 Medical education
Medical schools
Research
spellingShingle R735-854 Medical education
Medical schools
Research
Nazilah, Abdul Satar
The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells
description Cancer stem cells (CSCs) represent a small subpopulation within a tumour that possesses the stem-like properties but are also initiating resistance towards cytotoxic agent which contribute to cancer relapse. A natural compound such as curcumin that contains high polyphenol has been found to possess chemo-sensitivity effect with an ability to sensitise the CSCs to the cytotoxic agents such as cisplatin. Therefore, the present study was designed to investigate the efficiency of curcumin as a chemo-sensitiser in lung CSCs and to analyse its inhibitory effect on CSCs activity using A549 and H2170 cell lines that belong to non-small cell lung cancer (NSCLC).
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Nazilah, Abdul Satar
author_facet Nazilah, Abdul Satar
author_sort Nazilah, Abdul Satar
title The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells
title_short The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells
title_full The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells
title_fullStr The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells
title_full_unstemmed The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells
title_sort chemo-sensitisation effect of curcumin against low dose cisplatin on non-small cell lung cancer (nsclc) stem cells
granting_institution Universiti Sains Malaysia
granting_department Institut Perubatan & Pergigian Termaju
publishDate 2018
url http://eprints.usm.my/45013/1/NAZILAH%20ABDUL%20SATAR.pdf
_version_ 1747821438007508992

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