Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein
The capsid protein plays seminal roles in both early and late stages of the HIV replication cycle. Hence, HIV-1 capsid protein is considered an important target for developing novel drugs to treat HIV/AIDS. Capsid molecule (CA)-targeting peptide inhibitors (CAP-1, CAI and NYAD-1) have been reported...
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2015
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my-usm-ep.450742019-07-26T01:21:06Z Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein 2015-08 Teow, Sin Yeang R735-854 Medical education. Medical schools. Research The capsid protein plays seminal roles in both early and late stages of the HIV replication cycle. Hence, HIV-1 capsid protein is considered an important target for developing novel drugs to treat HIV/AIDS. Capsid molecule (CA)-targeting peptide inhibitors (CAP-1, CAI and NYAD-1) have been reported to disrupt the capsid protein functions in HIV-infected cells. However, the peptides are less stable in the blood, thus resulting in rapid clearance from the system and they can exhibit off-target activities. Monoclonal antibodies (MAbs) on the other hand, are stable and highly specific molecule, 2015-08 Thesis http://eprints.usm.my/45074/ http://eprints.usm.my/45074/1/TEOW%20SIN%20YEANG.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju |
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Universiti Sains Malaysia |
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USM Institutional Repository |
| language |
English |
| topic |
R735-854 Medical education Medical schools Research |
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R735-854 Medical education Medical schools Research Teow, Sin Yeang Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein |
| description |
The capsid protein plays seminal roles in both early and late stages of the HIV replication cycle. Hence, HIV-1 capsid protein is considered an important target for developing novel drugs to treat HIV/AIDS. Capsid molecule (CA)-targeting peptide inhibitors (CAP-1, CAI and NYAD-1) have been reported to disrupt the capsid protein functions in HIV-infected cells. However, the peptides are less stable in the blood, thus resulting in rapid clearance from the system and they can exhibit off-target activities. Monoclonal antibodies (MAbs) on the other hand, are stable and highly specific molecule, |
| format |
Thesis |
| qualification_name |
Doctor of Philosophy (PhD.) |
| qualification_level |
Doctorate |
| author |
Teow, Sin Yeang |
| author_facet |
Teow, Sin Yeang |
| author_sort |
Teow, Sin Yeang |
| title |
Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein |
| title_short |
Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein |
| title_full |
Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein |
| title_fullStr |
Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein |
| title_full_unstemmed |
Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein |
| title_sort |
cell-penetrating antibodies for targeting hiv-1 p24 capsid protein |
| granting_institution |
Universiti Sains Malaysia |
| granting_department |
Institut Perubatan & Pergigian Termaju |
| publishDate |
2015 |
| url |
http://eprints.usm.my/45074/1/TEOW%20SIN%20YEANG.pdf |
| _version_ |
1747821450932256768 |