The utility of beta 2 microglobulin (B2M) as an initial diagnostic tool for oral squamous cell carcinoma (OSCC) : evidence from a Malaysian sample

Background The delay in diagnosis of oral squamous cell carcinoma (OSCC) is a factor in rendering the poor prognosis, and recent research has explored the use of serum tumour markers such Beta 2 Microglobulin (B2M), to aid early diagnosis. However, despite a high incidence of OSCC in Southeast A...

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Main Author:	Narayanan, Maithrea Suresh
Format:	Thesis
Language:	English
Published:	2017
Subjects:	RB Pathology
Online Access:	http://eprints.usm.my/45212/1/Dr.%20Matihrea%20Suresh%20Narayana-24%20pages.pdf
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id	my-usm-ep.45212
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spelling	my-usm-ep.452122020-10-22T03:03:15Z The utility of beta 2 microglobulin (B2M) as an initial diagnostic tool for oral squamous cell carcinoma (OSCC) : evidence from a Malaysian sample 2017 Narayanan, Maithrea Suresh RB Pathology Background The delay in diagnosis of oral squamous cell carcinoma (OSCC) is a factor in rendering the poor prognosis, and recent research has explored the use of serum tumour markers such Beta 2 Microglobulin (B2M), to aid early diagnosis. However, despite a high incidence of OSCC in Southeast Asia, no studies on the clinical use of B2M in the region were found. Objectives: To determine if serum B2M level can serve as an initial diagnostic tool to indicate if a biopsy is warranted, and if so, to propose a local B2M serum reference value to identify OSSC patients Methodology: Twenty-one patients diagnosed with OSCC were seen at Hospital Universiti Sains Malaysia (HUSM) over a one-year period, between June 2016 and June 2017, and an equal number of healthy controls participated in the study. Apart from patient history, venous blood of approximately 5ml volume was collected from each subject at the pre-treatment stage and analysed by an Abbot ARCHITECT c8000 analyser using the immunoturbidometry method.The results were analysed using ROC analysis and the Mann Whitney test. Results: Serum B2M levels showed a statistically significant increase (p<0.001) in patients compared to controls. The test was shown to have 90.5% sensitivity and 90.5% specificity. It was found to be a sensitive and specific serum tumour marker at a cut off value of 1.57 mg/l to differentiate cases from controls. Conclusion: B2M is a sensitive and specific tumour marker to differentiate OSCC cases from controls. It is cost effective and minimally invasive, making it a potentially useful adjunct diagnostic tool in a high-risk patient pool. 2017 Thesis http://eprints.usm.my/45212/ http://eprints.usm.my/45212/1/Dr.%20Matihrea%20Suresh%20Narayana-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RB Pathology
spellingShingle	RB Pathology Narayanan, Maithrea Suresh The utility of beta 2 microglobulin (B2M) as an initial diagnostic tool for oral squamous cell carcinoma (OSCC) : evidence from a Malaysian sample
description	Background The delay in diagnosis of oral squamous cell carcinoma (OSCC) is a factor in rendering the poor prognosis, and recent research has explored the use of serum tumour markers such Beta 2 Microglobulin (B2M), to aid early diagnosis. However, despite a high incidence of OSCC in Southeast Asia, no studies on the clinical use of B2M in the region were found. Objectives: To determine if serum B2M level can serve as an initial diagnostic tool to indicate if a biopsy is warranted, and if so, to propose a local B2M serum reference value to identify OSSC patients Methodology: Twenty-one patients diagnosed with OSCC were seen at Hospital Universiti Sains Malaysia (HUSM) over a one-year period, between June 2016 and June 2017, and an equal number of healthy controls participated in the study. Apart from patient history, venous blood of approximately 5ml volume was collected from each subject at the pre-treatment stage and analysed by an Abbot ARCHITECT c8000 analyser using the immunoturbidometry method.The results were analysed using ROC analysis and the Mann Whitney test. Results: Serum B2M levels showed a statistically significant increase (p<0.001) in patients compared to controls. The test was shown to have 90.5% sensitivity and 90.5% specificity. It was found to be a sensitive and specific serum tumour marker at a cut off value of 1.57 mg/l to differentiate cases from controls. Conclusion: B2M is a sensitive and specific tumour marker to differentiate OSCC cases from controls. It is cost effective and minimally invasive, making it a potentially useful adjunct diagnostic tool in a high-risk patient pool.
format	Thesis
qualification_level	Master's degree
author	Narayanan, Maithrea Suresh
author_facet	Narayanan, Maithrea Suresh
author_sort	Narayanan, Maithrea Suresh
title	The utility of beta 2 microglobulin (B2M) as an initial diagnostic tool for oral squamous cell carcinoma (OSCC) : evidence from a Malaysian sample
title_short	The utility of beta 2 microglobulin (B2M) as an initial diagnostic tool for oral squamous cell carcinoma (OSCC) : evidence from a Malaysian sample
title_full	The utility of beta 2 microglobulin (B2M) as an initial diagnostic tool for oral squamous cell carcinoma (OSCC) : evidence from a Malaysian sample
title_fullStr	The utility of beta 2 microglobulin (B2M) as an initial diagnostic tool for oral squamous cell carcinoma (OSCC) : evidence from a Malaysian sample
title_full_unstemmed	The utility of beta 2 microglobulin (B2M) as an initial diagnostic tool for oral squamous cell carcinoma (OSCC) : evidence from a Malaysian sample
title_sort	utility of beta 2 microglobulin (b2m) as an initial diagnostic tool for oral squamous cell carcinoma (oscc) : evidence from a malaysian sample
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2017
url	http://eprints.usm.my/45212/1/Dr.%20Matihrea%20Suresh%20Narayana-24%20pages.pdf
_version_	1747821470034165760

The utility of beta 2 microglobulin (B2M) as an initial diagnostic tool for oral squamous cell carcinoma (OSCC) : evidence from a Malaysian sample

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