Synthesis, Characterization, Nucleolytic, Antibacterial And Antiproliferative Properties Of Vanadium, Copper And Manganese Complexes

Series of vanadium carboxylato complexes, copper carboxylato complexes, manganese carboxylato complexes and vanadium phenanthroline derivative complexes have been synthesized and characterized. The details of all the complexes are tabulated in Table 2.2 (page 37). The complexes have been characteriz...

Full description

Saved in:

Bibliographic Details
Main Author:	Lim, Eng Khoon
Format:	Thesis
Language:	English
Published:	2011
Subjects:	QD1-999 Chemistry
Online Access:	http://eprints.usm.my/45308/1/LIM%20ENG%20KHOON24.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.45308
record_format	uketd_dc
spelling	my-usm-ep.453082019-08-30T07:33:25Z Synthesis, Characterization, Nucleolytic, Antibacterial And Antiproliferative Properties Of Vanadium, Copper And Manganese Complexes 2011-07 Lim, Eng Khoon QD1-999 Chemistry Series of vanadium carboxylato complexes, copper carboxylato complexes, manganese carboxylato complexes and vanadium phenanthroline derivative complexes have been synthesized and characterized. The details of all the complexes are tabulated in Table 2.2 (page 37). The complexes have been characterized by X-ray crystallography, elemental analysis, FT-IR, UV–Vis spectroscopy and cyclic voltammetry. In electrochemistry studies, vanadium carboxylato complexes show redox active by displaying a quasi-reversible redox couple corresponding to VV/VIV redox process while copper carboxylato complexes show redox active by displaying two quasi-reversible redox couples corresponding to CuIICuII/CuIICuI and CuIICuI/CuICuI redox processes and manganese carboxylato complexes show redox active by displaying a quasi-reversible redox couple corresponding to MnII/MnIII redox process. In nucleolytic studies, all the complexes can induce oxidative DNA cleavage but in different manner. The copper carboxylato complexes and manganese carboxylato complexes can induce DNA cleavage in the presence of H2O2. Meanwhile for vanadium carboxylato complexes, vanadium(V) carboxylato complexes require H2O2 to induce DNA cleavage while vanadium(IV) carboxylato complexes do not require H2O2 to induce DNA cleavage.As for vanadium phenanthroline derivative complexes, they can induce DNA cleavage in the presence and in the absence of H2O2. However, the DNA cleavage activity of the vanadium phenanthroline derivative complexes is greatly enhanced in the presence of H2O2. Reactive oxygen species (ROS) scavengers have also been used to ascertain the reactive species responsible for DNA cleavage. The hydroxyl radical and singlet oxygen species have been found to be the ROS that are responsible in the DNA cleavage reaction. 2011-07 Thesis http://eprints.usm.my/45308/ http://eprints.usm.my/45308/1/LIM%20ENG%20KHOON24.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Kimia
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QD1-999 Chemistry
spellingShingle	QD1-999 Chemistry Lim, Eng Khoon Synthesis, Characterization, Nucleolytic, Antibacterial And Antiproliferative Properties Of Vanadium, Copper And Manganese Complexes
description	Series of vanadium carboxylato complexes, copper carboxylato complexes, manganese carboxylato complexes and vanadium phenanthroline derivative complexes have been synthesized and characterized. The details of all the complexes are tabulated in Table 2.2 (page 37). The complexes have been characterized by X-ray crystallography, elemental analysis, FT-IR, UV–Vis spectroscopy and cyclic voltammetry. In electrochemistry studies, vanadium carboxylato complexes show redox active by displaying a quasi-reversible redox couple corresponding to VV/VIV redox process while copper carboxylato complexes show redox active by displaying two quasi-reversible redox couples corresponding to CuIICuII/CuIICuI and CuIICuI/CuICuI redox processes and manganese carboxylato complexes show redox active by displaying a quasi-reversible redox couple corresponding to MnII/MnIII redox process. In nucleolytic studies, all the complexes can induce oxidative DNA cleavage but in different manner. The copper carboxylato complexes and manganese carboxylato complexes can induce DNA cleavage in the presence of H2O2. Meanwhile for vanadium carboxylato complexes, vanadium(V) carboxylato complexes require H2O2 to induce DNA cleavage while vanadium(IV) carboxylato complexes do not require H2O2 to induce DNA cleavage.As for vanadium phenanthroline derivative complexes, they can induce DNA cleavage in the presence and in the absence of H2O2. However, the DNA cleavage activity of the vanadium phenanthroline derivative complexes is greatly enhanced in the presence of H2O2. Reactive oxygen species (ROS) scavengers have also been used to ascertain the reactive species responsible for DNA cleavage. The hydroxyl radical and singlet oxygen species have been found to be the ROS that are responsible in the DNA cleavage reaction.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Lim, Eng Khoon
author_facet	Lim, Eng Khoon
author_sort	Lim, Eng Khoon
title	Synthesis, Characterization, Nucleolytic, Antibacterial And Antiproliferative Properties Of Vanadium, Copper And Manganese Complexes
title_short	Synthesis, Characterization, Nucleolytic, Antibacterial And Antiproliferative Properties Of Vanadium, Copper And Manganese Complexes
title_full	Synthesis, Characterization, Nucleolytic, Antibacterial And Antiproliferative Properties Of Vanadium, Copper And Manganese Complexes
title_fullStr	Synthesis, Characterization, Nucleolytic, Antibacterial And Antiproliferative Properties Of Vanadium, Copper And Manganese Complexes
title_full_unstemmed	Synthesis, Characterization, Nucleolytic, Antibacterial And Antiproliferative Properties Of Vanadium, Copper And Manganese Complexes
title_sort	synthesis, characterization, nucleolytic, antibacterial and antiproliferative properties of vanadium, copper and manganese complexes
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kimia
publishDate	2011
url	http://eprints.usm.my/45308/1/LIM%20ENG%20KHOON24.pdf
_version_	1747821484499271680

Synthesis, Characterization, Nucleolytic, Antibacterial And Antiproliferative Properties Of Vanadium, Copper And Manganese Complexes

Similar Items