The Relationship Between The Blood Concentration Of Isoniazid, Rifampicin, Pyrazinamide And The Treatment Outcomes Of Pulmonary Tuberculosis Patients

The Relationship Between The Blood Concentration Of Isoniazid, Rifampicin, Pyrazinamide And The Treatment Outcomes Of Pulmonary Tuberculosis Patients

A prospective cohort study was conducted in Hospital Pulau Pinang to find out the determinants of the pharmacokinetics of isoniazid (INH), rifampicin (RIF), and pyrazinamide (PZA), and to assess the effect of these pharmacokinetic parameters on the treatment outcomes of pulmonary tuberculosis patien...

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Main Author: Mahjoub, Abdallah Abdallah
Format: Thesis
Language:English
Published: 2017
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/45321/1/ABDALLAH%20ABDALLAH%20MAHJOUB.pdf
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spelling my-usm-ep.453212019-09-06T01:22:12Z The Relationship Between The Blood Concentration Of Isoniazid, Rifampicin, Pyrazinamide And The Treatment Outcomes Of Pulmonary Tuberculosis Patients 2017-04 Mahjoub, Abdallah Abdallah RS1-441 Pharmacy and materia medica A prospective cohort study was conducted in Hospital Pulau Pinang to find out the determinants of the pharmacokinetics of isoniazid (INH), rifampicin (RIF), and pyrazinamide (PZA), and to assess the effect of these pharmacokinetic parameters on the treatment outcomes of pulmonary tuberculosis patients. Plasma concentration of INH, RIF, and PZA was measured by new HPLC methods developed and validated as part of this study. The median of maximum plasma concentration (Cmax) of INH, RIF, and PZA was 4.75, 6.85, and 42.00 mg/L respectively. The median of the area under the time -concentration curve from zero to 24 hours (AUC0-24h) of INH and RIF was 20.1 and 33.2mg × h/ L respectively. 2017-04 Thesis http://eprints.usm.my/45321/ http://eprints.usm.my/45321/1/ABDALLAH%20ABDALLAH%20MAHJOUB.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Mahjoub, Abdallah Abdallah
The Relationship Between The Blood Concentration Of Isoniazid, Rifampicin, Pyrazinamide And The Treatment Outcomes Of Pulmonary Tuberculosis Patients
description A prospective cohort study was conducted in Hospital Pulau Pinang to find out the determinants of the pharmacokinetics of isoniazid (INH), rifampicin (RIF), and pyrazinamide (PZA), and to assess the effect of these pharmacokinetic parameters on the treatment outcomes of pulmonary tuberculosis patients. Plasma concentration of INH, RIF, and PZA was measured by new HPLC methods developed and validated as part of this study. The median of maximum plasma concentration (Cmax) of INH, RIF, and PZA was 4.75, 6.85, and 42.00 mg/L respectively. The median of the area under the time -concentration curve from zero to 24 hours (AUC0-24h) of INH and RIF was 20.1 and 33.2mg × h/ L respectively.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Mahjoub, Abdallah Abdallah
author_facet Mahjoub, Abdallah Abdallah
author_sort Mahjoub, Abdallah Abdallah
title The Relationship Between The Blood Concentration Of Isoniazid, Rifampicin, Pyrazinamide And The Treatment Outcomes Of Pulmonary Tuberculosis Patients
title_short The Relationship Between The Blood Concentration Of Isoniazid, Rifampicin, Pyrazinamide And The Treatment Outcomes Of Pulmonary Tuberculosis Patients
title_full The Relationship Between The Blood Concentration Of Isoniazid, Rifampicin, Pyrazinamide And The Treatment Outcomes Of Pulmonary Tuberculosis Patients
title_fullStr The Relationship Between The Blood Concentration Of Isoniazid, Rifampicin, Pyrazinamide And The Treatment Outcomes Of Pulmonary Tuberculosis Patients
title_full_unstemmed The Relationship Between The Blood Concentration Of Isoniazid, Rifampicin, Pyrazinamide And The Treatment Outcomes Of Pulmonary Tuberculosis Patients
title_sort relationship between the blood concentration of isoniazid, rifampicin, pyrazinamide and the treatment outcomes of pulmonary tuberculosis patients
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Farmasi
publishDate 2017
url http://eprints.usm.my/45321/1/ABDALLAH%20ABDALLAH%20MAHJOUB.pdf
_version_ 1747821486696038400

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