Comparison of dry eyes parameters in postmenopausal women with and without honey supplement

Background Dry eyes is one of the most common ocular surface problems among elderly particularly among postmenopausal women due to hormonal imbalance. Ocular surface inflammation and tears hyperosmolarity are known pathogenesis of dry eyes. Objective The objective of this study is to compare the mea...

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Main Author:	Baharuddin, Noorlaila
Format:	Thesis
Language:	English
Published:	2017
Subjects:	RE Ophthalmology
Online Access:	http://eprints.usm.my/45339/1/Dr.%20Noorlaila%20Baharuddin-24%20pages.pdf
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spelling	my-usm-ep.453392020-10-22T03:03:13Z Comparison of dry eyes parameters in postmenopausal women with and without honey supplement 2017 Baharuddin, Noorlaila RE Ophthalmology Background Dry eyes is one of the most common ocular surface problems among elderly particularly among postmenopausal women due to hormonal imbalance. Ocular surface inflammation and tears hyperosmolarity are known pathogenesis of dry eyes. Objective The objective of this study is to compare the mean change (baseline and three months post treatment) in symptom [base on Ocular Surface Disease Index (OSDI) score] and signs (Schirmer test value and TBUT) between oral supplementation of honey cocktail and nonhoney groups among postmenopausal women. Methods A randomised interventional study was conducted from November 2015 to May 2017, at Hospital Universiti Sains Malaysia, Kelantan, Malaysia. The eligible postmenopausal women were randomised into 2 groups (honey cocktail group and non-honey group) by using random sampling envelope technique. Participants were assessed for OSDI score using OSDI questionnaire and evaluated for Schirmer test value and TBUT at baseline and at 3 months after daily oral supplementation of 20g honey cocktail. Statistical analyses were performed using SPSS version 22.0. Only right eye was chosen to analyse for standardization.Results A total of 60 postmenopausal women were recruited (30 participants in honey cocktail group and 30 participants in non-honey group). Honey cocktail group showed reduction of disability of OSDI score and improvement in Schirmer test value at 3 months post honey supplementation compared to non-honey group. There was no significant difference in mean change of OSDI score (p=0.644), Schirmer test value (p=0.372) and TBUT (p=0.471) between honey cocktail and non-honey groups. Conclusion Postmenopausal women with honey cocktail supplements shows better clinical response compared to non-honey group. However, there was no significant difference between the two groups. Further studies with longer duration of honey supplementation is recommended as honey have a slow effect. Oxidative stress and inflammatory markers are essential to establish the effect of honey supplements in postmenopausal women. 2017 Thesis http://eprints.usm.my/45339/ http://eprints.usm.my/45339/1/Dr.%20Noorlaila%20Baharuddin-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RE Ophthalmology
spellingShingle	RE Ophthalmology Baharuddin, Noorlaila Comparison of dry eyes parameters in postmenopausal women with and without honey supplement
description	Background Dry eyes is one of the most common ocular surface problems among elderly particularly among postmenopausal women due to hormonal imbalance. Ocular surface inflammation and tears hyperosmolarity are known pathogenesis of dry eyes. Objective The objective of this study is to compare the mean change (baseline and three months post treatment) in symptom [base on Ocular Surface Disease Index (OSDI) score] and signs (Schirmer test value and TBUT) between oral supplementation of honey cocktail and nonhoney groups among postmenopausal women. Methods A randomised interventional study was conducted from November 2015 to May 2017, at Hospital Universiti Sains Malaysia, Kelantan, Malaysia. The eligible postmenopausal women were randomised into 2 groups (honey cocktail group and non-honey group) by using random sampling envelope technique. Participants were assessed for OSDI score using OSDI questionnaire and evaluated for Schirmer test value and TBUT at baseline and at 3 months after daily oral supplementation of 20g honey cocktail. Statistical analyses were performed using SPSS version 22.0. Only right eye was chosen to analyse for standardization.Results A total of 60 postmenopausal women were recruited (30 participants in honey cocktail group and 30 participants in non-honey group). Honey cocktail group showed reduction of disability of OSDI score and improvement in Schirmer test value at 3 months post honey supplementation compared to non-honey group. There was no significant difference in mean change of OSDI score (p=0.644), Schirmer test value (p=0.372) and TBUT (p=0.471) between honey cocktail and non-honey groups. Conclusion Postmenopausal women with honey cocktail supplements shows better clinical response compared to non-honey group. However, there was no significant difference between the two groups. Further studies with longer duration of honey supplementation is recommended as honey have a slow effect. Oxidative stress and inflammatory markers are essential to establish the effect of honey supplements in postmenopausal women.
format	Thesis
qualification_level	Master's degree
author	Baharuddin, Noorlaila
author_facet	Baharuddin, Noorlaila
author_sort	Baharuddin, Noorlaila
title	Comparison of dry eyes parameters in postmenopausal women with and without honey supplement
title_short	Comparison of dry eyes parameters in postmenopausal women with and without honey supplement
title_full	Comparison of dry eyes parameters in postmenopausal women with and without honey supplement
title_fullStr	Comparison of dry eyes parameters in postmenopausal women with and without honey supplement
title_full_unstemmed	Comparison of dry eyes parameters in postmenopausal women with and without honey supplement
title_sort	comparison of dry eyes parameters in postmenopausal women with and without honey supplement
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2017
url	http://eprints.usm.my/45339/1/Dr.%20Noorlaila%20Baharuddin-24%20pages.pdf
_version_	1747821489627856896

Comparison of dry eyes parameters in postmenopausal women with and without honey supplement

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