Disturbed gut microbiota explains persistent abdominal pain after a major environmental disaster

Background: It is unknown if there is association between abdominal pain and poor water, sanitation and hygiene (WaSH) practices and if small intestinal bacterial overgrowth (SIBO) and/or gut dysbiosis explains abdominal pain after a major flood. Methods: Abdominal symptoms, quality of life, ps...

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Main Author:	Yusof, Nurfadhilah
Format:	Thesis
Language:	English
Published:	2017
Subjects:	RC799-869 Diseases of the digestive system Gastroenterology
Online Access:	http://eprints.usm.my/45369/1/Dr.%20Nurfadhillah%20Yusof-24%20pages.pdf
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id	my-usm-ep.45369
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spelling	my-usm-ep.453692020-10-22T03:03:16Z Disturbed gut microbiota explains persistent abdominal pain after a major environmental disaster 2017 Yusof, Nurfadhilah RC799-869 Diseases of the digestive system. Gastroenterology Background: It is unknown if there is association between abdominal pain and poor water, sanitation and hygiene (WaSH) practices and if small intestinal bacterial overgrowth (SIBO) and/or gut dysbiosis explains abdominal pain after a major flood. Methods: Abdominal symptoms, quality of life, psychological disturbances, WaSH practices, SIBO and stools for high-throughput sequencing were assessed in flood victims. Results: Of 211 participants (mean age 54.5 years, females 71%), 37.9% had abdominal pain. Poor WaSH practices during flood and irritable bowel syndrome (IBS) were associated with abdominal pain (both P < 0.04). Those with abdominal pain experienced worse quality of life and more anxiety (both P < 0.05). SIBO was associated with abdominal pain (P = 0.01), poor water practices during flood (P = 0.04) and limited physical functioning (P = 0.02). Using linear discriminant analysis effect size method, gut dysbiosis was observed in those with anxiety (Bacteroidetes and Proteobacteria, effect size 4.8), abdominal pain (Fusobacteria, Staphylococcus, Megamonas and Plesiomonas, effect size 4.0) and IBS (Plesiomonas and Trabulsiella, effect size 3.0). Conclusions: Disturbed gut microbiota because of environmentally-derived organisms may explain persistent abdominal pain after a major environmental disaster in the presence of poor WaSH practices. 2017 Thesis http://eprints.usm.my/45369/ http://eprints.usm.my/45369/1/Dr.%20Nurfadhillah%20Yusof-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC799-869 Diseases of the digestive system Gastroenterology
spellingShingle	RC799-869 Diseases of the digestive system Gastroenterology Yusof, Nurfadhilah Disturbed gut microbiota explains persistent abdominal pain after a major environmental disaster
description	Background: It is unknown if there is association between abdominal pain and poor water, sanitation and hygiene (WaSH) practices and if small intestinal bacterial overgrowth (SIBO) and/or gut dysbiosis explains abdominal pain after a major flood. Methods: Abdominal symptoms, quality of life, psychological disturbances, WaSH practices, SIBO and stools for high-throughput sequencing were assessed in flood victims. Results: Of 211 participants (mean age 54.5 years, females 71%), 37.9% had abdominal pain. Poor WaSH practices during flood and irritable bowel syndrome (IBS) were associated with abdominal pain (both P < 0.04). Those with abdominal pain experienced worse quality of life and more anxiety (both P < 0.05). SIBO was associated with abdominal pain (P = 0.01), poor water practices during flood (P = 0.04) and limited physical functioning (P = 0.02). Using linear discriminant analysis effect size method, gut dysbiosis was observed in those with anxiety (Bacteroidetes and Proteobacteria, effect size 4.8), abdominal pain (Fusobacteria, Staphylococcus, Megamonas and Plesiomonas, effect size 4.0) and IBS (Plesiomonas and Trabulsiella, effect size 3.0). Conclusions: Disturbed gut microbiota because of environmentally-derived organisms may explain persistent abdominal pain after a major environmental disaster in the presence of poor WaSH practices.
format	Thesis
qualification_level	Master's degree
author	Yusof, Nurfadhilah
author_facet	Yusof, Nurfadhilah
author_sort	Yusof, Nurfadhilah
title	Disturbed gut microbiota explains persistent abdominal pain after a major environmental disaster
title_short	Disturbed gut microbiota explains persistent abdominal pain after a major environmental disaster
title_full	Disturbed gut microbiota explains persistent abdominal pain after a major environmental disaster
title_fullStr	Disturbed gut microbiota explains persistent abdominal pain after a major environmental disaster
title_full_unstemmed	Disturbed gut microbiota explains persistent abdominal pain after a major environmental disaster
title_sort	disturbed gut microbiota explains persistent abdominal pain after a major environmental disaster
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2017
url	http://eprints.usm.my/45369/1/Dr.%20Nurfadhillah%20Yusof-24%20pages.pdf
_version_	1747821495982227456

Disturbed gut microbiota explains persistent abdominal pain after a major environmental disaster

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