Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein

Antigen recognition by T cell receptor (TCR) induces intracellular signaling cascades leading to T cell activation, subsequently inducing cellular proliferation and various effector functions. Adaptor proteins play important roles in T cell signaling by creating nodes to recruit signaling proteins a...

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Main Author:	Kong, Mei Suen
Format:	Thesis
Language:	English
Published:	2017
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/45399/1/KONG%20MEI%20SUEN.pdf
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id	my-usm-ep.45399
record_format	uketd_dc
spelling	my-usm-ep.453992019-09-12T01:39:18Z Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein 2017-01 Kong, Mei Suen RS1-441 Pharmacy and materia medica Antigen recognition by T cell receptor (TCR) induces intracellular signaling cascades leading to T cell activation, subsequently inducing cellular proliferation and various effector functions. Adaptor proteins play important roles in T cell signaling by creating nodes to recruit signaling proteins and form signal complexes to regulate the direction of signaling. Casitas B-lineage lymphoma (Cbl)-interacting protein of 85 kDa (CIN85) is an adaptor protein, originally identified as a Cbl-binding protein, and was suggested to be involved in the internalization and degradation of receptors and kinases. Nevertheless, the physiological function of CIN85 in T cells is unknown. 2017-01 Thesis http://eprints.usm.my/45399/ http://eprints.usm.my/45399/1/KONG%20MEI%20SUEN.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Kong, Mei Suen Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein
description	Antigen recognition by T cell receptor (TCR) induces intracellular signaling cascades leading to T cell activation, subsequently inducing cellular proliferation and various effector functions. Adaptor proteins play important roles in T cell signaling by creating nodes to recruit signaling proteins and form signal complexes to regulate the direction of signaling. Casitas B-lineage lymphoma (Cbl)-interacting protein of 85 kDa (CIN85) is an adaptor protein, originally identified as a Cbl-binding protein, and was suggested to be involved in the internalization and degradation of receptors and kinases. Nevertheless, the physiological function of CIN85 in T cells is unknown.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Kong, Mei Suen
author_facet	Kong, Mei Suen
author_sort	Kong, Mei Suen
title	Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein
title_short	Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein
title_full	Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein
title_fullStr	Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein
title_full_unstemmed	Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein
title_sort	negative regulation of t cell activation and function by cin85 adaptor protein
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2017
url	http://eprints.usm.my/45399/1/KONG%20MEI%20SUEN.pdf
_version_	1747821502567284736

Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein

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