Modelling And Syntheses Of Vanillin Derivatives Targeting Influenza Virus Neuraminidase
Influenza remains a serious global threat. To date, zanamivir and oseltamivir used as NA inhibitors were reported to be resistant to influenza virus. Therefore, new and effective NA inhibitors must be discovered. In this study, pharmacophore modelling approach was used to search for NA inhibitors wi...
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2016
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my-usm-ep.454182019-09-13T01:54:19Z Modelling And Syntheses Of Vanillin Derivatives Targeting Influenza Virus Neuraminidase 2016-11 Asaruddin, Mohd Razip RS1-441 Pharmacy and materia medica Influenza remains a serious global threat. To date, zanamivir and oseltamivir used as NA inhibitors were reported to be resistant to influenza virus. Therefore, new and effective NA inhibitors must be discovered. In this study, pharmacophore modelling approach was used to search for NA inhibitors with new scaffold. Two computer softwares such as Discovery Studio 2.5 and LigandScout 3.1 was utilized. Through the softwares, the pharmacophore modelling approaches was generated. Ligand-based and structure-based pharmacophore modelling approaches will complement each other. Ligand-based pharmacophore modelling approach is based on common features functional groups. 2016-11 Thesis http://eprints.usm.my/45418/ http://eprints.usm.my/45418/1/MOHD%20RAZIP%20ASARUDDIN.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi |
| institution |
Universiti Sains Malaysia |
| collection |
USM Institutional Repository |
| language |
English |
| topic |
RS1-441 Pharmacy and materia medica |
| spellingShingle |
RS1-441 Pharmacy and materia medica Asaruddin, Mohd Razip Modelling And Syntheses Of Vanillin Derivatives Targeting Influenza Virus Neuraminidase |
| description |
Influenza remains a serious global threat. To date, zanamivir and oseltamivir used as NA inhibitors were reported to be resistant to influenza virus. Therefore, new and effective NA inhibitors must be discovered. In this study, pharmacophore modelling approach was used to search for NA inhibitors with new scaffold. Two computer softwares such as Discovery Studio 2.5 and LigandScout 3.1 was utilized. Through the softwares, the pharmacophore modelling approaches was generated. Ligand-based and structure-based pharmacophore modelling approaches will complement each other. Ligand-based pharmacophore modelling approach is based on common features functional groups. |
| format |
Thesis |
| qualification_name |
Doctor of Philosophy (PhD.) |
| qualification_level |
Doctorate |
| author |
Asaruddin, Mohd Razip |
| author_facet |
Asaruddin, Mohd Razip |
| author_sort |
Asaruddin, Mohd Razip |
| title |
Modelling And Syntheses Of Vanillin Derivatives Targeting Influenza Virus Neuraminidase |
| title_short |
Modelling And Syntheses Of Vanillin Derivatives Targeting Influenza Virus Neuraminidase |
| title_full |
Modelling And Syntheses Of Vanillin Derivatives Targeting Influenza Virus Neuraminidase |
| title_fullStr |
Modelling And Syntheses Of Vanillin Derivatives Targeting Influenza Virus Neuraminidase |
| title_full_unstemmed |
Modelling And Syntheses Of Vanillin Derivatives Targeting Influenza Virus Neuraminidase |
| title_sort |
modelling and syntheses of vanillin derivatives targeting influenza virus neuraminidase |
| granting_institution |
Universiti Sains Malaysia |
| granting_department |
Pusat Pengajian Sains Farmasi |
| publishDate |
2016 |
| url |
http://eprints.usm.my/45418/1/MOHD%20RAZIP%20ASARUDDIN.pdf |
| _version_ |
1747821507192553472 |