Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma

It is commonly believed without sufficient evidence that the impairment of the ability to undergo apoptosis (a mode of programmed cell death) in response to conventional treatment such as cytotoxic drugs, gained melanoma its notorious resistance to therapy. Studies to determine the contribution of t...

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Main Author:	Phang,, Su Ling
Format:	Thesis
Language:	English
Published:	2017
Subjects:	QH1 Natural history (General - Including nature conservation geographical distribution)
Online Access:	http://eprints.usm.my/45479/1/PHANG%20SU%20LING.pdf
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id	my-usm-ep.45479
record_format	uketd_dc
spelling	my-usm-ep.454792019-09-19T01:05:11Z Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma 2017-07 Phang,, Su Ling QH1 Natural history (General - Including nature conservation, geographical distribution) It is commonly believed without sufficient evidence that the impairment of the ability to undergo apoptosis (a mode of programmed cell death) in response to conventional treatment such as cytotoxic drugs, gained melanoma its notorious resistance to therapy. Studies to determine the contribution of the intrinsic apoptosis pathway for melanomagenesis are often deterred by utilisation of in vitro cell culture models and xenograft models. An established mouse model of melanoma, the Cdkn2a -/-, Tyr-HRASG12V, was utilised in this study to obviate limitations posted by the usage of in vitro and xenograft models. 2017-07 Thesis http://eprints.usm.my/45479/ http://eprints.usm.my/45479/1/PHANG%20SU%20LING.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Kajihayat
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QH1 Natural history (General - Including nature conservation geographical distribution)
spellingShingle	QH1 Natural history (General - Including nature conservation geographical distribution) Phang,, Su Ling Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma
description	It is commonly believed without sufficient evidence that the impairment of the ability to undergo apoptosis (a mode of programmed cell death) in response to conventional treatment such as cytotoxic drugs, gained melanoma its notorious resistance to therapy. Studies to determine the contribution of the intrinsic apoptosis pathway for melanomagenesis are often deterred by utilisation of in vitro cell culture models and xenograft models. An established mouse model of melanoma, the Cdkn2a -/-, Tyr-HRASG12V, was utilised in this study to obviate limitations posted by the usage of in vitro and xenograft models.
format	Thesis
qualification_level	Master's degree
author	Phang,, Su Ling
author_facet	Phang,, Su Ling
author_sort	Phang,, Su Ling
title	Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma
title_short	Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma
title_full	Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma
title_fullStr	Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma
title_full_unstemmed	Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma
title_sort	defeciancy of puma and noxa for melanomagenesis in a mouse model of melanoma
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kajihayat
publishDate	2017
url	http://eprints.usm.my/45479/1/PHANG%20SU%20LING.pdf
_version_	1747821518884175872

Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma

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