The effects of 5% albumin and 4% gelatin solution on renal function, haemodynamic stability and blood loss in patient undergoing CABG (coronary artery bypass grafting in HUSM

Background: The most ideal approach on cardiopulmonary bypass (CPB) priming and intravenous fluid choice during Coronary Artery Bypass Grafting (CABG) remains controversial. Methods: Thirty four patients undergoing elective CABG were studied. Patients were excluded if they scheduled for emergenc...

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Main Author:	Shahidan, Nur Zurairah
Format:	Thesis
Language:	English
Published:	2017
Subjects:	RC666-701 Diseases of the circulatory (Cardiovascular) system
Online Access:	http://eprints.usm.my/45518/1/Dr.%20Nurzurairah%20Shahidan-24%20pages.pdf
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spelling	my-usm-ep.455182020-10-22T03:03:15Z The effects of 5% albumin and 4% gelatin solution on renal function, haemodynamic stability and blood loss in patient undergoing CABG (coronary artery bypass grafting in HUSM 2017 Shahidan, Nur Zurairah RC666-701 Diseases of the circulatory (Cardiovascular) system Background: The most ideal approach on cardiopulmonary bypass (CPB) priming and intravenous fluid choice during Coronary Artery Bypass Grafting (CABG) remains controversial. Methods: Thirty four patients undergoing elective CABG were studied. Patients were excluded if they scheduled for emergency CABG, on known nephrotoxic drug or have a history of allergy to colloid. Patients were randomly assigned to two groups of 5% albumin (n=18) and 4% gelatin (n=16). Haemodynamic parameters, serum level of urea, creatinine, sodium and urine level of sodium and creatinine was measured preoperatively, immediately after the operation, day 1, 2 and 3 post-operatively. Hemoglobin level was taken preoperatively, immediately post-operation, day 1 and 2 after operation. Cathecolamines and vasodilator requirement was also recorded until day 2 post operation. Glomerular filtration rate (GFR), Fractional Excretion of Sodium (FeNa) was calculated and compared. Results: mean difference of GFR was significantly higher in 4% gelatin group throughout the study but the FeNa difference was not statistically significant. On the topic of haemodynamic stability, the mean arterial blood pressure (MAP) during cardio pulmonary bypass was significantly higher in 5% albumin group (63.9±3.73 mmHg, P value=0.011). Cathecolamines and vasodilator requirement showed no remarkable difference. Intraoperative blood loss was lower in 5% albumin group with mean of 1425.33 (±451.81) mL whereas in 4% gelatin group 1514.44 (±697.67) mL but the difference was not significant(P value= 0.658). Intraoperatively, less blood transfusion was required in 5% albumin group(22.2%) compared to 4% gelatin group (43.8%)Conclusion: Administration of 5% albumin and 4% gelatin in patients undergoing CABG showed no remarkable difference on renal function parameters, haemodynamic stability and blood loss. 2017 Thesis http://eprints.usm.my/45518/ http://eprints.usm.my/45518/1/Dr.%20Nurzurairah%20Shahidan-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC666-701 Diseases of the circulatory (Cardiovascular) system
spellingShingle	RC666-701 Diseases of the circulatory (Cardiovascular) system Shahidan, Nur Zurairah The effects of 5% albumin and 4% gelatin solution on renal function, haemodynamic stability and blood loss in patient undergoing CABG (coronary artery bypass grafting in HUSM
description	Background: The most ideal approach on cardiopulmonary bypass (CPB) priming and intravenous fluid choice during Coronary Artery Bypass Grafting (CABG) remains controversial. Methods: Thirty four patients undergoing elective CABG were studied. Patients were excluded if they scheduled for emergency CABG, on known nephrotoxic drug or have a history of allergy to colloid. Patients were randomly assigned to two groups of 5% albumin (n=18) and 4% gelatin (n=16). Haemodynamic parameters, serum level of urea, creatinine, sodium and urine level of sodium and creatinine was measured preoperatively, immediately after the operation, day 1, 2 and 3 post-operatively. Hemoglobin level was taken preoperatively, immediately post-operation, day 1 and 2 after operation. Cathecolamines and vasodilator requirement was also recorded until day 2 post operation. Glomerular filtration rate (GFR), Fractional Excretion of Sodium (FeNa) was calculated and compared. Results: mean difference of GFR was significantly higher in 4% gelatin group throughout the study but the FeNa difference was not statistically significant. On the topic of haemodynamic stability, the mean arterial blood pressure (MAP) during cardio pulmonary bypass was significantly higher in 5% albumin group (63.9±3.73 mmHg, P value=0.011). Cathecolamines and vasodilator requirement showed no remarkable difference. Intraoperative blood loss was lower in 5% albumin group with mean of 1425.33 (±451.81) mL whereas in 4% gelatin group 1514.44 (±697.67) mL but the difference was not significant(P value= 0.658). Intraoperatively, less blood transfusion was required in 5% albumin group(22.2%) compared to 4% gelatin group (43.8%)Conclusion: Administration of 5% albumin and 4% gelatin in patients undergoing CABG showed no remarkable difference on renal function parameters, haemodynamic stability and blood loss.
format	Thesis
qualification_level	Master's degree
author	Shahidan, Nur Zurairah
author_facet	Shahidan, Nur Zurairah
author_sort	Shahidan, Nur Zurairah
title	The effects of 5% albumin and 4% gelatin solution on renal function, haemodynamic stability and blood loss in patient undergoing CABG (coronary artery bypass grafting in HUSM
title_short	The effects of 5% albumin and 4% gelatin solution on renal function, haemodynamic stability and blood loss in patient undergoing CABG (coronary artery bypass grafting in HUSM
title_full	The effects of 5% albumin and 4% gelatin solution on renal function, haemodynamic stability and blood loss in patient undergoing CABG (coronary artery bypass grafting in HUSM
title_fullStr	The effects of 5% albumin and 4% gelatin solution on renal function, haemodynamic stability and blood loss in patient undergoing CABG (coronary artery bypass grafting in HUSM
title_full_unstemmed	The effects of 5% albumin and 4% gelatin solution on renal function, haemodynamic stability and blood loss in patient undergoing CABG (coronary artery bypass grafting in HUSM
title_sort	effects of 5% albumin and 4% gelatin solution on renal function, haemodynamic stability and blood loss in patient undergoing cabg (coronary artery bypass grafting in husm
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2017
url	http://eprints.usm.my/45518/1/Dr.%20Nurzurairah%20Shahidan-24%20pages.pdf
_version_	1747821527199383552

The effects of 5% albumin and 4% gelatin solution on renal function, haemodynamic stability and blood loss in patient undergoing CABG (coronary artery bypass grafting in HUSM

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