Syntheses, Characterization And Biological Activities Of New Hydrazinyl Thiazolyl Coumarin Derivatives

Coumarin and thiazole are two important pharmacophores, the syntheses of which acquire great importance in medicinal chemistry due to the diverse pharmacological activities. The present study aims to synthesize some (45) new biologically active compounds by incorporating thiazole ring with coumarin...

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Main Author:	Arshad, Afsheen
Format:	Thesis
Language:	English
Published:	2011
Subjects:	QD1-999 Chemistry
Online Access:	http://eprints.usm.my/45587/1/AFSHEEN%20ARSHAD_HJ.pdf
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id	my-usm-ep.45587
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spelling	my-usm-ep.455872019-10-08T02:24:30Z Syntheses, Characterization And Biological Activities Of New Hydrazinyl Thiazolyl Coumarin Derivatives 2011 Arshad, Afsheen QD1-999 Chemistry Coumarin and thiazole are two important pharmacophores, the syntheses of which acquire great importance in medicinal chemistry due to the diverse pharmacological activities. The present study aims to synthesize some (45) new biologically active compounds by incorporating thiazole ring with coumarin nucleus. Two new series of hydrazinyl thiazolyl coumarin derivatives have been synthesized in four steps. The first step of the synthesis was the preparation of acetyl coumarins by Knoevenagel’s condensation of substituted salicyaldehydes with ethyl acetoacetate in the presence of catalytic amount of piperidine. In the second step, bromination of acetyl coumarins was carried out with bromine in order to yield the corresponding bromoacetyl coumarins. Thiosemicarbazones were synthesized in the third step by treating thiosemicarbazide with various substituted aldehydes and ketones in the presence of a catalytic amount of glacial acetic acid. The final step of the synthesis involved the preparation of two new series of hydrazinyl thiazolyl coumarins using Hantzsch cyclization protocol. One series of compounds was obtained by reacting 3-bromoacetyl coumarins with thiosemicarbazones derived from various substituted aldehydes, while the other series was furnished by treating thiosemicarbazones of substituted ketones with 3-bromoacetylcoumarins. All the synthesized compounds were fully characterized by IR, 1H and 13C NMR, elemental analysis and mass spectroscopy. 2011 Thesis http://eprints.usm.my/45587/ http://eprints.usm.my/45587/1/AFSHEEN%20ARSHAD_HJ.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Kimia
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QD1-999 Chemistry
spellingShingle	QD1-999 Chemistry Arshad, Afsheen Syntheses, Characterization And Biological Activities Of New Hydrazinyl Thiazolyl Coumarin Derivatives
description	Coumarin and thiazole are two important pharmacophores, the syntheses of which acquire great importance in medicinal chemistry due to the diverse pharmacological activities. The present study aims to synthesize some (45) new biologically active compounds by incorporating thiazole ring with coumarin nucleus. Two new series of hydrazinyl thiazolyl coumarin derivatives have been synthesized in four steps. The first step of the synthesis was the preparation of acetyl coumarins by Knoevenagel’s condensation of substituted salicyaldehydes with ethyl acetoacetate in the presence of catalytic amount of piperidine. In the second step, bromination of acetyl coumarins was carried out with bromine in order to yield the corresponding bromoacetyl coumarins. Thiosemicarbazones were synthesized in the third step by treating thiosemicarbazide with various substituted aldehydes and ketones in the presence of a catalytic amount of glacial acetic acid. The final step of the synthesis involved the preparation of two new series of hydrazinyl thiazolyl coumarins using Hantzsch cyclization protocol. One series of compounds was obtained by reacting 3-bromoacetyl coumarins with thiosemicarbazones derived from various substituted aldehydes, while the other series was furnished by treating thiosemicarbazones of substituted ketones with 3-bromoacetylcoumarins. All the synthesized compounds were fully characterized by IR, 1H and 13C NMR, elemental analysis and mass spectroscopy.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Arshad, Afsheen
author_facet	Arshad, Afsheen
author_sort	Arshad, Afsheen
title	Syntheses, Characterization And Biological Activities Of New Hydrazinyl Thiazolyl Coumarin Derivatives
title_short	Syntheses, Characterization And Biological Activities Of New Hydrazinyl Thiazolyl Coumarin Derivatives
title_full	Syntheses, Characterization And Biological Activities Of New Hydrazinyl Thiazolyl Coumarin Derivatives
title_fullStr	Syntheses, Characterization And Biological Activities Of New Hydrazinyl Thiazolyl Coumarin Derivatives
title_full_unstemmed	Syntheses, Characterization And Biological Activities Of New Hydrazinyl Thiazolyl Coumarin Derivatives
title_sort	syntheses, characterization and biological activities of new hydrazinyl thiazolyl coumarin derivatives
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kimia
publishDate	2011
url	http://eprints.usm.my/45587/1/AFSHEEN%20ARSHAD_HJ.pdf
_version_	1747821533311533056

Syntheses, Characterization And Biological Activities Of New Hydrazinyl Thiazolyl Coumarin Derivatives

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