The period prevalence of double expression diffuse large B-cell lymphoma patients and its associated risk factors and treatment response in Hospital Universiti Sains Malaysia from 2004 to 2015

Background and Objective: Diffuse Large B-Cell Lymphoma (DLBCL) is a heterogeneous and complex disease. Its protein expression of MYC and BCL2 and/or BLC6 (Double Expression) is associated with poor response to standard treatment, thus poor prognosis. The aim is to determine the period prevalence o...

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Main Author:	Yong, Teh Chee
Format:	Thesis
Language:	English
Published:	2017
Subjects:	RC Internal medicine
Online Access:	http://eprints.usm.my/45621/1/Dr.%20Teh%20Chee%20Yong-24%20pages.pdf
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id	my-usm-ep.45621
record_format	uketd_dc
spelling	my-usm-ep.456212020-10-22T03:03:16Z The period prevalence of double expression diffuse large B-cell lymphoma patients and its associated risk factors and treatment response in Hospital Universiti Sains Malaysia from 2004 to 2015 2017 Yong, Teh Chee RC Internal medicine Background and Objective: Diffuse Large B-Cell Lymphoma (DLBCL) is a heterogeneous and complex disease. Its protein expression of MYC and BCL2 and/or BLC6 (Double Expression) is associated with poor response to standard treatment, thus poor prognosis. The aim is to determine the period prevalence of Double Expression phenotype in DLBCL patients and also its associated risk factors and treatment response Methods: We performed a retrospective record review involving adult DLBCL patients from 2004 to 2015 in Hospital Universiti Sains Malaysia. Demographic, clinical and laboratory information were extracted from medical record, whereas double expression status was extracted from histopathology department database. Results: A total of 27 DLBCL patients were recruited in this study. The period prevalence of Double Expression Phenotypes was 59.3%. It was not significantly associated with early response during interim assessment (p=0.182); but was significantly associated with non-complete responserate toward RCHOP regimen (p=0.002). It only significantly associated with serum LDH level (p=0.015). There was no significant association between age, gender, ethnicity, stages, B symptoms, ECOG status, revised IPI, Extra-nodal, CNS and bone marrow involvement with Double Expression phenotype. Conclusion: The period prevalence of Double Expression Phenotypes was 59.3%. Patients with Double Expression Phenotypes were associated with lower chance to achieve Complete Response with RCHOP regimen. Among the selected variables, raised serum LDH remained the significant factor associated with Double Expression Phenotypes. 2017 Thesis http://eprints.usm.my/45621/ http://eprints.usm.my/45621/1/Dr.%20Teh%20Chee%20Yong-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Yong, Teh Chee The period prevalence of double expression diffuse large B-cell lymphoma patients and its associated risk factors and treatment response in Hospital Universiti Sains Malaysia from 2004 to 2015
description	Background and Objective: Diffuse Large B-Cell Lymphoma (DLBCL) is a heterogeneous and complex disease. Its protein expression of MYC and BCL2 and/or BLC6 (Double Expression) is associated with poor response to standard treatment, thus poor prognosis. The aim is to determine the period prevalence of Double Expression phenotype in DLBCL patients and also its associated risk factors and treatment response Methods: We performed a retrospective record review involving adult DLBCL patients from 2004 to 2015 in Hospital Universiti Sains Malaysia. Demographic, clinical and laboratory information were extracted from medical record, whereas double expression status was extracted from histopathology department database. Results: A total of 27 DLBCL patients were recruited in this study. The period prevalence of Double Expression Phenotypes was 59.3%. It was not significantly associated with early response during interim assessment (p=0.182); but was significantly associated with non-complete responserate toward RCHOP regimen (p=0.002). It only significantly associated with serum LDH level (p=0.015). There was no significant association between age, gender, ethnicity, stages, B symptoms, ECOG status, revised IPI, Extra-nodal, CNS and bone marrow involvement with Double Expression phenotype. Conclusion: The period prevalence of Double Expression Phenotypes was 59.3%. Patients with Double Expression Phenotypes were associated with lower chance to achieve Complete Response with RCHOP regimen. Among the selected variables, raised serum LDH remained the significant factor associated with Double Expression Phenotypes.
format	Thesis
qualification_level	Master's degree
author	Yong, Teh Chee
author_facet	Yong, Teh Chee
author_sort	Yong, Teh Chee
title	The period prevalence of double expression diffuse large B-cell lymphoma patients and its associated risk factors and treatment response in Hospital Universiti Sains Malaysia from 2004 to 2015
title_short	The period prevalence of double expression diffuse large B-cell lymphoma patients and its associated risk factors and treatment response in Hospital Universiti Sains Malaysia from 2004 to 2015
title_full	The period prevalence of double expression diffuse large B-cell lymphoma patients and its associated risk factors and treatment response in Hospital Universiti Sains Malaysia from 2004 to 2015
title_fullStr	The period prevalence of double expression diffuse large B-cell lymphoma patients and its associated risk factors and treatment response in Hospital Universiti Sains Malaysia from 2004 to 2015
title_full_unstemmed	The period prevalence of double expression diffuse large B-cell lymphoma patients and its associated risk factors and treatment response in Hospital Universiti Sains Malaysia from 2004 to 2015
title_sort	period prevalence of double expression diffuse large b-cell lymphoma patients and its associated risk factors and treatment response in hospital universiti sains malaysia from 2004 to 2015
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2017
url	http://eprints.usm.my/45621/1/Dr.%20Teh%20Chee%20Yong-24%20pages.pdf
_version_	1747821536761348096

The period prevalence of double expression diffuse large B-cell lymphoma patients and its associated risk factors and treatment response in Hospital Universiti Sains Malaysia from 2004 to 2015

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