Effect of endomentrial rceptivity on in vitro fertilization/intracytoplasmic sperm injection outcome in HUSM

Effect of endomentrial rceptivity on in vitro fertilization/intracytoplasmic sperm injection outcome in HUSM

OBJECTIVE: To evaluate the association of endometrial receptivity by means of endometrial thickness, endometrial morphology and the level of serum progesterone with the outcome of in vitro fertilization/ intracytoplasmic sperm injection (IVF/ ICSI) cycles. STUDY METHOD: This prospective study was p...

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Main Author: Mohamadzon, Erinna
Format: Thesis
Language:English
Published: 2018
Subjects:
RG Gynecology and obstetrics
Online Access:http://eprints.usm.my/45869/1/Dr.%20Erinna%20Mohamadzon-24%20pages.pdf
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spelling my-usm-ep.458692019-12-31T07:37:30Z Effect of endomentrial rceptivity on in vitro fertilization/intracytoplasmic sperm injection outcome in HUSM 2018 Mohamadzon, Erinna RG Gynecology and obstetrics OBJECTIVE: To evaluate the association of endometrial receptivity by means of endometrial thickness, endometrial morphology and the level of serum progesterone with the outcome of in vitro fertilization/ intracytoplasmic sperm injection (IVF/ ICSI) cycles. STUDY METHOD: This prospective study was performed over a period of 18 months in Hospital USM Fertility Unit. A total of 50 patients going to receive IVF/ICSI cycles participated in the study. 50 subjects had undergone controlled ovarian hyperstimulation protocol until mature follicles were observed. On the day when the patient is to receive hCG injection, the endometrial thickness, endometrial morphology and the level of serum progesterone were determined. Oocyte retrieval was done which was followed by IVF or ICSI. The developed embryos were transferred into the uterus at blastocyst stage. Serum beta hCG was measured 14 days after embryo transfer. The association between endometrial thickness, endometrial morphology and level of serum progesterone with pregnancy was analyzed. RESULT: Pregnancy was achieved in 10 out of 50 patients (20.0%). The mean endometrial thickness for the pregnant group was 9.86 ±1.68 mm, whilst 9.77+ 2.53 mm in the non-pregnant group. 7 out of 10 pregnant patients had trilaminar endometrium. The mean progesterone level during the hCG day was 3.717 ± 1.071 nmol/L for the pregnant group and 1.408 ± 4.691 nmol/L for the non-pregnant group. All differences were not statistically significant. CONCLUSION: Endometrial thickness, endometrial morphology and the level of serum progesterone on the hCG day was not significantly associated with the outcome of IVF/ ICSI cycles. However, this finding was guarded by the small sample size. 2018 Thesis http://eprints.usm.my/45869/ http://eprints.usm.my/45869/1/Dr.%20Erinna%20Mohamadzon-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RG Gynecology and obstetrics
spellingShingle RG Gynecology and obstetrics
Mohamadzon, Erinna
Effect of endomentrial rceptivity on in vitro fertilization/intracytoplasmic sperm injection outcome in HUSM
description OBJECTIVE: To evaluate the association of endometrial receptivity by means of endometrial thickness, endometrial morphology and the level of serum progesterone with the outcome of in vitro fertilization/ intracytoplasmic sperm injection (IVF/ ICSI) cycles. STUDY METHOD: This prospective study was performed over a period of 18 months in Hospital USM Fertility Unit. A total of 50 patients going to receive IVF/ICSI cycles participated in the study. 50 subjects had undergone controlled ovarian hyperstimulation protocol until mature follicles were observed. On the day when the patient is to receive hCG injection, the endometrial thickness, endometrial morphology and the level of serum progesterone were determined. Oocyte retrieval was done which was followed by IVF or ICSI. The developed embryos were transferred into the uterus at blastocyst stage. Serum beta hCG was measured 14 days after embryo transfer. The association between endometrial thickness, endometrial morphology and level of serum progesterone with pregnancy was analyzed. RESULT: Pregnancy was achieved in 10 out of 50 patients (20.0%). The mean endometrial thickness for the pregnant group was 9.86 ±1.68 mm, whilst 9.77+ 2.53 mm in the non-pregnant group. 7 out of 10 pregnant patients had trilaminar endometrium. The mean progesterone level during the hCG day was 3.717 ± 1.071 nmol/L for the pregnant group and 1.408 ± 4.691 nmol/L for the non-pregnant group. All differences were not statistically significant. CONCLUSION: Endometrial thickness, endometrial morphology and the level of serum progesterone on the hCG day was not significantly associated with the outcome of IVF/ ICSI cycles. However, this finding was guarded by the small sample size.
format Thesis
qualification_level Master's degree
author Mohamadzon, Erinna
author_facet Mohamadzon, Erinna
author_sort Mohamadzon, Erinna
title Effect of endomentrial rceptivity on in vitro fertilization/intracytoplasmic sperm injection outcome in HUSM
title_short Effect of endomentrial rceptivity on in vitro fertilization/intracytoplasmic sperm injection outcome in HUSM
title_full Effect of endomentrial rceptivity on in vitro fertilization/intracytoplasmic sperm injection outcome in HUSM
title_fullStr Effect of endomentrial rceptivity on in vitro fertilization/intracytoplasmic sperm injection outcome in HUSM
title_full_unstemmed Effect of endomentrial rceptivity on in vitro fertilization/intracytoplasmic sperm injection outcome in HUSM
title_sort effect of endomentrial rceptivity on in vitro fertilization/intracytoplasmic sperm injection outcome in husm
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Perubatan
publishDate 2018
url http://eprints.usm.my/45869/1/Dr.%20Erinna%20Mohamadzon-24%20pages.pdf
_version_ 1747821582535884800

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