Evaluation of ocular manifestations and its predictors in dengue patients in Hospital Selayang

Background: Dengue is the most rapidly spreading mosquito-borne disease in the world causing a substantial public health burden in the Western Pacific Region. It is a major cause of mortality and morbidity in Malaysia. Malaysia is hyperendemic for dengue, as evidenced by simultaneous presence of...

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Main Author:	Bakar, Farah Abu
Format:	Thesis
Language:	English
Published:	2018
Subjects:	RE Ophthalmology
Online Access:	http://eprints.usm.my/45894/1/Dr.%20Farah%20Abu%20Bakar-24%20pages.pdf
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spelling	my-usm-ep.458942020-01-15T04:12:17Z Evaluation of ocular manifestations and its predictors in dengue patients in Hospital Selayang 2018 Bakar, Farah Abu RE Ophthalmology Background: Dengue is the most rapidly spreading mosquito-borne disease in the world causing a substantial public health burden in the Western Pacific Region. It is a major cause of mortality and morbidity in Malaysia. Malaysia is hyperendemic for dengue, as evidenced by simultaneous presence of all four dengue serotypes (DENV-1, DENV-2, DENV-3, DENV-4). However, the predominant serotype differs from year to year and varies across the different states in Malaysia. Dengue fever has a wide spectrum of clinical manifestations with varying degrees of severity. Different dengue serotypes may contribute to the variability and severity of manifestations. Over the recent years, there has been increasing numbers of cases of ocular manifestations in dengue, from mild selflimiting presentation to sight threatening conditions. Objectives: The objectives of this study are to determine the prevalence of ocular manifestations in dengue patients, to determine the association between ocular manifestations and the different serotypes of dengue virus and to identify the predictors of ocular manifestations in dengue. Methods: This is a cross-sectional study conducted in Hospital Selayang, Gombak, Malaysia. One hundred and thirty eight patients diagnosed with dengue fever were recruited from January 2017 to January 2018. Complete ocular examination was done for each patient including assessment of macula thickness using Heidelberg Spectral-Domain Optical Coherence Tomography (OCT). Serum blood sample is sent for full blood count and dengue serotype. Reverse transcription- polymerase chain reaction (RT-PCR) method was used to identify the dengue serotypes DENV-1, DENV-2, DENV-3 and DENV-4. Findings were analysed using Statistical Package for Social Sciences (SPSS) comparing ocular manifestations among the different dengue serotypes. Results: Ocular manifestations were present in 18 (13%) patients from the study. Fourteen (10%) patients had eye redness. Subconjunctival haemorrhage was the commonest eye findings seen in 14 patients in which 9 (64%) patients were infected by DENV-1 (p=0.019). Fundus findings were present in 3 patients including 2 maculopathy. One patient had anterior uveitis and is found to be associated with DENV-3 (p= 0.014)Age, gender, ethnicity and full blood count values including platelet level were found not to be significant predictors in this study (p>0.05). Conclusion: Ocular manifestations are prevalent amongst dengue patients. There is association between specific dengue serotype with ocular manifestations. There is no significant predictors of dengue ocular manifestation identified in this study. Further research and larger studies need to be conducted to evaluate correlation between the different serotypes with other types of ocular manifestation and its severity. 2018 Thesis http://eprints.usm.my/45894/ http://eprints.usm.my/45894/1/Dr.%20Farah%20Abu%20Bakar-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RE Ophthalmology
spellingShingle	RE Ophthalmology Bakar, Farah Abu Evaluation of ocular manifestations and its predictors in dengue patients in Hospital Selayang
description	Background: Dengue is the most rapidly spreading mosquito-borne disease in the world causing a substantial public health burden in the Western Pacific Region. It is a major cause of mortality and morbidity in Malaysia. Malaysia is hyperendemic for dengue, as evidenced by simultaneous presence of all four dengue serotypes (DENV-1, DENV-2, DENV-3, DENV-4). However, the predominant serotype differs from year to year and varies across the different states in Malaysia. Dengue fever has a wide spectrum of clinical manifestations with varying degrees of severity. Different dengue serotypes may contribute to the variability and severity of manifestations. Over the recent years, there has been increasing numbers of cases of ocular manifestations in dengue, from mild selflimiting presentation to sight threatening conditions. Objectives: The objectives of this study are to determine the prevalence of ocular manifestations in dengue patients, to determine the association between ocular manifestations and the different serotypes of dengue virus and to identify the predictors of ocular manifestations in dengue. Methods: This is a cross-sectional study conducted in Hospital Selayang, Gombak, Malaysia. One hundred and thirty eight patients diagnosed with dengue fever were recruited from January 2017 to January 2018. Complete ocular examination was done for each patient including assessment of macula thickness using Heidelberg Spectral-Domain Optical Coherence Tomography (OCT). Serum blood sample is sent for full blood count and dengue serotype. Reverse transcription- polymerase chain reaction (RT-PCR) method was used to identify the dengue serotypes DENV-1, DENV-2, DENV-3 and DENV-4. Findings were analysed using Statistical Package for Social Sciences (SPSS) comparing ocular manifestations among the different dengue serotypes. Results: Ocular manifestations were present in 18 (13%) patients from the study. Fourteen (10%) patients had eye redness. Subconjunctival haemorrhage was the commonest eye findings seen in 14 patients in which 9 (64%) patients were infected by DENV-1 (p=0.019). Fundus findings were present in 3 patients including 2 maculopathy. One patient had anterior uveitis and is found to be associated with DENV-3 (p= 0.014)Age, gender, ethnicity and full blood count values including platelet level were found not to be significant predictors in this study (p>0.05). Conclusion: Ocular manifestations are prevalent amongst dengue patients. There is association between specific dengue serotype with ocular manifestations. There is no significant predictors of dengue ocular manifestation identified in this study. Further research and larger studies need to be conducted to evaluate correlation between the different serotypes with other types of ocular manifestation and its severity.
format	Thesis
qualification_level	Master's degree
author	Bakar, Farah Abu
author_facet	Bakar, Farah Abu
author_sort	Bakar, Farah Abu
title	Evaluation of ocular manifestations and its predictors in dengue patients in Hospital Selayang
title_short	Evaluation of ocular manifestations and its predictors in dengue patients in Hospital Selayang
title_full	Evaluation of ocular manifestations and its predictors in dengue patients in Hospital Selayang
title_fullStr	Evaluation of ocular manifestations and its predictors in dengue patients in Hospital Selayang
title_full_unstemmed	Evaluation of ocular manifestations and its predictors in dengue patients in Hospital Selayang
title_sort	evaluation of ocular manifestations and its predictors in dengue patients in hospital selayang
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2018
url	http://eprints.usm.my/45894/1/Dr.%20Farah%20Abu%20Bakar-24%20pages.pdf
_version_	1747821585011572736

Evaluation of ocular manifestations and its predictors in dengue patients in Hospital Selayang

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