Genetic Polymorphisms In The Phase I And Phase II Xenobiotic Metabolizing Enzymes In Malaysian Population And Their Influence On Colorectal Cancer Susceptibility

Sporadic Colorectal Cancer (CRC) is a multifactorial disease and factors contributing to its etiopathogenesis include dietary and lifestyle habits on one hand and genetic predisposition on the other hand. Exposure to environmental carcinogens through dietary components and cigarette smoke are associ...

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Main Author:	Shahpudin, Siti Nurfatimah Mohd
Format:	Thesis
Language:	English
Published:	2012
Subjects:	R735-854 Medical education Medical schools Research
Online Access:	http://eprints.usm.my/45961/1/SITI%20NURFATIMAH_HJ.pdf
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id	my-usm-ep.45961
record_format	uketd_dc
spelling	my-usm-ep.459612020-01-22T01:47:48Z Genetic Polymorphisms In The Phase I And Phase II Xenobiotic Metabolizing Enzymes In Malaysian Population And Their Influence On Colorectal Cancer Susceptibility 2012 Shahpudin, Siti Nurfatimah Mohd R735-854 Medical education. Medical schools. Research Sporadic Colorectal Cancer (CRC) is a multifactorial disease and factors contributing to its etiopathogenesis include dietary and lifestyle habits on one hand and genetic predisposition on the other hand. Exposure to environmental carcinogens through dietary components and cigarette smoke are associated with an increased risk of CRC. However, the genetic predisposition factors associated with CRC development largely remain undetermined. It was hypothesized that genetic variations in xenobiotic metabolism genes may play a role in how individuals will respond to carcinogenic compounds and hence affect the risk of developing CRC. So, this case-control study which involved 566 study subjects (255 histopathologically confirmed sporadic CRC patients and 311 normal healthy controls) was designed and undertaken at Human Genome Centre, University Sains Malaysia during the period 2009-2011, to investigate the influence of genetic polymorphisms of few xenobiotic metabolizing genes in CRC susceptibility risk. Ten polymorphisms from 6 genes encoding enzymes involved in xenobiotic metabolism (GSTT1, GSTM1, GSTP1 Ile105Val, CYP1A2 G3860A, CYP1A2 T739G, CYP1A2 C729T, NAT1 C1095A, NAT2 G191A, NAT2 A803G, NAT2 G857A) were selected as candidate SNPs to determine their influence, either singly or as combination genotypes, in CRC susceptibility risk and with the ultimate aim of identifying putatively protective and/or at risk genotypes. 2012 Thesis http://eprints.usm.my/45961/ http://eprints.usm.my/45961/1/SITI%20NURFATIMAH_HJ.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R735-854 Medical education Medical schools Research
spellingShingle	R735-854 Medical education Medical schools Research Shahpudin, Siti Nurfatimah Mohd Genetic Polymorphisms In The Phase I And Phase II Xenobiotic Metabolizing Enzymes In Malaysian Population And Their Influence On Colorectal Cancer Susceptibility
description	Sporadic Colorectal Cancer (CRC) is a multifactorial disease and factors contributing to its etiopathogenesis include dietary and lifestyle habits on one hand and genetic predisposition on the other hand. Exposure to environmental carcinogens through dietary components and cigarette smoke are associated with an increased risk of CRC. However, the genetic predisposition factors associated with CRC development largely remain undetermined. It was hypothesized that genetic variations in xenobiotic metabolism genes may play a role in how individuals will respond to carcinogenic compounds and hence affect the risk of developing CRC. So, this case-control study which involved 566 study subjects (255 histopathologically confirmed sporadic CRC patients and 311 normal healthy controls) was designed and undertaken at Human Genome Centre, University Sains Malaysia during the period 2009-2011, to investigate the influence of genetic polymorphisms of few xenobiotic metabolizing genes in CRC susceptibility risk. Ten polymorphisms from 6 genes encoding enzymes involved in xenobiotic metabolism (GSTT1, GSTM1, GSTP1 Ile105Val, CYP1A2 G3860A, CYP1A2 T739G, CYP1A2 C729T, NAT1 C1095A, NAT2 G191A, NAT2 A803G, NAT2 G857A) were selected as candidate SNPs to determine their influence, either singly or as combination genotypes, in CRC susceptibility risk and with the ultimate aim of identifying putatively protective and/or at risk genotypes.
format	Thesis
qualification_level	Master's degree
author	Shahpudin, Siti Nurfatimah Mohd
author_facet	Shahpudin, Siti Nurfatimah Mohd
author_sort	Shahpudin, Siti Nurfatimah Mohd
title	Genetic Polymorphisms In The Phase I And Phase II Xenobiotic Metabolizing Enzymes In Malaysian Population And Their Influence On Colorectal Cancer Susceptibility
title_short	Genetic Polymorphisms In The Phase I And Phase II Xenobiotic Metabolizing Enzymes In Malaysian Population And Their Influence On Colorectal Cancer Susceptibility
title_full	Genetic Polymorphisms In The Phase I And Phase II Xenobiotic Metabolizing Enzymes In Malaysian Population And Their Influence On Colorectal Cancer Susceptibility
title_fullStr	Genetic Polymorphisms In The Phase I And Phase II Xenobiotic Metabolizing Enzymes In Malaysian Population And Their Influence On Colorectal Cancer Susceptibility
title_full_unstemmed	Genetic Polymorphisms In The Phase I And Phase II Xenobiotic Metabolizing Enzymes In Malaysian Population And Their Influence On Colorectal Cancer Susceptibility
title_sort	genetic polymorphisms in the phase i and phase ii xenobiotic metabolizing enzymes in malaysian population and their influence on colorectal cancer susceptibility
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2012
url	http://eprints.usm.my/45961/1/SITI%20NURFATIMAH_HJ.pdf
_version_	1747821591136305152

Genetic Polymorphisms In The Phase I And Phase II Xenobiotic Metabolizing Enzymes In Malaysian Population And Their Influence On Colorectal Cancer Susceptibility

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