The effect of modified alternate day calorie restriction on non-alcoholic fatty liver disease (NAFLD)

Introduction: NAFLD is a serious medical issue worldwide. Various diet modifications had been implemented to improve liver steatosis. SWE is an emerging technique that offers non-invasive method of liver steatosis assessment. In this study, we aimed to compare the liver steatosis grading and live...

Full description

Saved in:

Bibliographic Details
Main Author:	Yusoff, Khairiah Mat
Format:	Thesis
Language:	English
Published:	2018
Subjects:	RC799-869 Diseases of the digestive system Gastroenterology
Online Access:	http://eprints.usm.my/46020/1/Dr.%20Khairiah%20Binti%20Mat%20Yusoff-24%20pages.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.46020
record_format	uketd_dc
spelling	my-usm-ep.460202020-01-29T04:19:45Z The effect of modified alternate day calorie restriction on non-alcoholic fatty liver disease (NAFLD) 2018 Yusoff, Khairiah Mat RC799-869 Diseases of the digestive system. Gastroenterology Introduction: NAFLD is a serious medical issue worldwide. Various diet modifications had been implemented to improve liver steatosis. SWE is an emerging technique that offers non-invasive method of liver steatosis assessment. In this study, we aimed to compare the liver steatosis grading and liver elasticity among NAFLD patients who underwent 8 weeks of MADCR. Methodology: Using the Aixplorer® ultrasound, liver ultrasound of 39 subjects (32 interventional and 9 control subjects) were performed. Liver steatosis grading, fibrosis grading and shear wave elastography of all patients were acquired. Liver steatosis and liver elasticity level pre and post pre intervention were compared. Correlation of the liver steatosis and gradings were analysed using Kendall b tau analysis. Results: The mean liver steatosis grade and fibrosis level of the 30 participants in the intervention group were significantly reduced after MADCR (modified alternate day calorie restriction) programme. Our result showed that 10 patients had improved liver steatosis grading, whereby 8 patients improve from grade 2 to grade 1 and 2 patients from grade 1 to grade 0. Our study showed significant mean difference of liver elasticity in intervention group after MADCR (p value <0.001). From the analysis of the readings from all the participants (n=78), the SWE values showed significant weak correlation with the steatosis grading (0-3) of the fatty liver (P value 0.013). Conclusions: MADCR is beneficial to improve liver steatosis. SWE is a useful and reliable method to assess liver elasticity after intervention. 2018 Thesis http://eprints.usm.my/46020/ http://eprints.usm.my/46020/1/Dr.%20Khairiah%20Binti%20Mat%20Yusoff-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC799-869 Diseases of the digestive system Gastroenterology
spellingShingle	RC799-869 Diseases of the digestive system Gastroenterology Yusoff, Khairiah Mat The effect of modified alternate day calorie restriction on non-alcoholic fatty liver disease (NAFLD)
description	Introduction: NAFLD is a serious medical issue worldwide. Various diet modifications had been implemented to improve liver steatosis. SWE is an emerging technique that offers non-invasive method of liver steatosis assessment. In this study, we aimed to compare the liver steatosis grading and liver elasticity among NAFLD patients who underwent 8 weeks of MADCR. Methodology: Using the Aixplorer® ultrasound, liver ultrasound of 39 subjects (32 interventional and 9 control subjects) were performed. Liver steatosis grading, fibrosis grading and shear wave elastography of all patients were acquired. Liver steatosis and liver elasticity level pre and post pre intervention were compared. Correlation of the liver steatosis and gradings were analysed using Kendall b tau analysis. Results: The mean liver steatosis grade and fibrosis level of the 30 participants in the intervention group were significantly reduced after MADCR (modified alternate day calorie restriction) programme. Our result showed that 10 patients had improved liver steatosis grading, whereby 8 patients improve from grade 2 to grade 1 and 2 patients from grade 1 to grade 0. Our study showed significant mean difference of liver elasticity in intervention group after MADCR (p value <0.001). From the analysis of the readings from all the participants (n=78), the SWE values showed significant weak correlation with the steatosis grading (0-3) of the fatty liver (P value 0.013). Conclusions: MADCR is beneficial to improve liver steatosis. SWE is a useful and reliable method to assess liver elasticity after intervention.
format	Thesis
qualification_level	Master's degree
author	Yusoff, Khairiah Mat
author_facet	Yusoff, Khairiah Mat
author_sort	Yusoff, Khairiah Mat
title	The effect of modified alternate day calorie restriction on non-alcoholic fatty liver disease (NAFLD)
title_short	The effect of modified alternate day calorie restriction on non-alcoholic fatty liver disease (NAFLD)
title_full	The effect of modified alternate day calorie restriction on non-alcoholic fatty liver disease (NAFLD)
title_fullStr	The effect of modified alternate day calorie restriction on non-alcoholic fatty liver disease (NAFLD)
title_full_unstemmed	The effect of modified alternate day calorie restriction on non-alcoholic fatty liver disease (NAFLD)
title_sort	effect of modified alternate day calorie restriction on non-alcoholic fatty liver disease (nafld)
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2018
url	http://eprints.usm.my/46020/1/Dr.%20Khairiah%20Binti%20Mat%20Yusoff-24%20pages.pdf
_version_	1747821594802126848

The effect of modified alternate day calorie restriction on non-alcoholic fatty liver disease (NAFLD)

Similar Items